CV Lattes
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Universidade de São Paulo (USP). Instituto de Biociências (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Professor at the Department of Genetics and Evolutionary Biology at the Institute of Biosciences at the University of São Paulo. Expert in advanced therapies, focusing on stem cells and tissue engineering. PhD in Genetics from the University of São Paulo. Master's degree in Biological Sciences: Genetics and Biotechnology from the Federal University of Juiz de Fora. Graduated in Pharmacy from the Federal University of Juiz de Fora. Awarded member of the ISSCR. He served as a guest researcher at the Department of Bioengineering at Temple University - Philadelphia, at the TIME research center - Temple Institute for Regenerative Medicine and Engineering under the guidance of Dr. Peter I. Lelkes. He completed his doctorate under the guidance of Dr. Mayana Zatz. Works in the area of Genetics, Cellular and Molecular Biology and Physiology. He is currently a researcher at the Human Genome and Stem Cell Studies Center - USP and works in the area of tissue bioengineering/biomaterials, with a focus on liver tissue engineering (3D bioprinting and liver organoids) and genetic engineering, with a focus on xenotransplantation. (Source: Lattes Curriculum)
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After the development of modern genetic editing techniques, xenotransplantation became the potential solution to the shortage of organs for transplantation. Since 2017, our group has been leading a research effort for the development of genetically modified pigs for this purpose. With the support of XenoBrasil (startup that has EMS as a partner and some of the leading researchers of this …
Induced pluripotent stem cells (iPSCs) are reprogrammed cell lines derived in vitro from fibroblasts or erythroblasts which, similar to embryonic stem cells (ESCs), can differentiate into all tissues of an organism. Due to their high proliferative potential and permissiveness to gene editing and clonal selection, iPSCs are highly applicable for cellular therapies in humans. Immunological …
Induced pluripotent stem cells (iPSCs) are in vitro reprogrammed cell lines derived from fibroblasts or erythroblasts that, like embryonic stem cells (ESCs), have the ability to differentiate into all tissues of an organism. Due to their high proliferative potential and permissiveness to gene editing and clonal selection, iPSCs have great potential for cellular therapies in humans. Immuno…
Hepatic organoid technology holds great promise for the development of future Regenerative Medicine strategies to treat patients with severe liver disease. Recently, some studies have demonstrated robust protocols for isogenic organoid generation using induced Pluripotent Stem cells (iPS). However, using patient's specific iPS-derived cells poses a major challenge for a translational pers…
The liver is a key organ in the regulation of metabolism and hemodynamics. Several acute and chronic liver diseases (i.e. resulting from toxic exposures or congenital diseases) progress for a severe loss of hepatic function. Currently, the only therapeutic option for patients with end-stage and/or progressively severe liver disease is the partial or total organ transplant. Due to the shor…
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