Currently is the Principal Investigator responsible for a FAPESP Young Investigator Grant (Process no. 2023/07741-8; 05/01/2024 - 04/30/2029) at the School of Dentistry of Araraquara at the Sao Paulo State University (FOAr/UNESP). Has completed postdoctoral trainings at FOAr/UNESP (August/2019-April/2024), at Harvard Medical School (Boston, United States; April/2022-April/2023) and at the University of Pittsburgh (Pittsburgh, United States; April/2018 -June/2019). Received a PhD in Physiology from the Postgraduate Program in Physiology at the University of São Paulo, Ribeirão Preto Medical School (FMRP/USP; 2013-2018). During his PhD, received a scholarship to perform research studies at the University of Bristol (Bristol, England; July/2016-June/2017). He has a specialization in the Multiprofessional Integrated Residency program in Elderly Health from the Federal University of Triângulo Mineiro (2013) and a degree in Physical Education from the University of Uberaba (2009). He has experience in the areas of Neuroscience and Physiology, with an emphasis on Autonomic Nervous System and Physiology of the Cardiovascular and Respiratory Systems. He is interested in studying the mechanisms and neural circuits involved in cardiorespiratory control in physiological and pathological conditions. Furthermore, is interested in understanding how the nervous system and the immune system can interact in a bidirectional way. Main study techniques: In vivo electrophysiology, manipulation of specific neuronal populations, differentiation of human induced pluripotent stem cells (hIPSC) into neurons, RNA sequencing (RNA-Seq), calcium imaging, immunohistochemistry, and in situ hybridization fluorescent (RNAscope). (Source: Lattes Curriculum)
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Clinical and population studies document that many patients with chronic inflammatory diseases, including autoimmune pathologies such as rheumatoid arthritis and systemic lupus erythematosus, present autonomic dysfunctions. In most cases, these dysfunctions are characterized by increased sympathetic activity, which may contribute to the high cardiovascular morbidity and mortality risks ob…
Numerous studies have shown that norepinephrine modulates macrophage activity via alpha- and beta-adrenergic receptors across various contexts. However, due to technological and experimental limitations, these findings have been largely indirect, relying on exogenous substances (such as norepinephrine and adrenergic receptor blockers or activators) as proof of concept. In recent years, hu…
Emerging evidence indicates that inflammatory mediators produced by immune cells can significantly influence the function of neuronal circuits governing the autonomic nervous system. Both the sympathetic and parasympathetic branches of this system, in turn, have the capacity to affect immune cell activity. Notably, sympathetic premotor neurons in the rostral ventrolateral medulla (RVLM) a…
Neuroimmune interactions refer to the communication between the nervous system and the immune system, playing a crucial role in maintaining homeostasis and organizing responses to diseases. These interactions are bidirectional, meaning the nervous system can influence the immune response and vice versa. Circulating inflammatory mediators, synthesized and secreted by immune cells, affect n…
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Recent evidence has demonstrated that Renovascular Hypertension is characterized not only by an increase in sympathetic activity and activation of the renin-angiotensin-aldosterone system, but also by a peripheral inflammation with increased levels of circulating pro-inflammatory cytokines. Although the conventional therapeutic approaches for hypertension have targeted a reduction of symp…
The role of the carotid body in the context of cardiovascular diseases has been widely explored. In a recently published study (Hypertension 66: 598-603, 2015) our laboratory demonstrated that carotid body attenuate the hypotensive response to electrical stimulation of the carotid sinus/carotid sinus nerve in conscious rats. Although a recent clinical study has been suggested that electri…
The nervous and immune systems interact in a bidirectional manner, but the precise mechanisms governing this interplay are still unclear. Recently, we identified a previously unrecognized mechanism of neuroimmune interaction in which peripheral sensory organs (i.e., the carotid bodies) can detect the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) in the blood, activatin…
Although the causes of hypertension-related sympathoexcitation remain unknown, studies conducted in the laboratory of Professor Julian F. R. Paton (University of Bristol, Bristol, UK) have strongly suggested that the carotid body chemoreceptors may be responsible, at least in part, for this exacerbated sympathetic activity. In this way, the carotid body chemoreceptors may contribute both …
| 1 / 1 | Ongoing grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 2 / 2 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 9 / 9 | All research grants and scholarships |
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CV Lattes
ORCID