Abstract
Bisphosphonates (BPs) are widely used drugs for the treatment of osteolytic conditions, by acting in the inhibition of bone resorption process. High potency BPs, such as zoledronate, are used to control the progression of bone metastasis in osteotropic malignant neoplasms or for the treatment of severe osteoporosis. However, one of its adverse effects is the occurrence of the medication-r…