Abstract
The embryonic Wilms tumors are tumors that exhibit morphological heterogeneity with three components: blastema, epithelia and stroma. Mutations in WT1, CTNNB1, WTX, DROSHA, SIX2, MYCN, TP53, and others less common genes overlap and are found in 30% of the analyzed cases. Moreover, the loss of imprinting of 11p15, resulting in overexpression of IGF2 is found in about 70% of cases. Alone, n…