Jeremy Andrew Squire
CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation for the last research proposal) Birthplace: Inglaterra
Graduated from the University of London, UK, with a Masters in Genetics and a PhD in Medical Biophysics from the University of Toronto. Postdoc at Northwick Park Hospital, Harrow, UK (1988). Was director of Molecular Pathology, Hospital for Sick Children in Toronto (1989-1997). Professor in 2001 in the Department of Pathology at Queen's University in Kingston, Canada and Director of the Laboratory of Translational Research, NCIC - Clinical Trials Group (2008-13). He was visiting professor at the Cancer Hospital of São Paulo (AC Camargo) in the period 2006-2007 and of Barretos Cancer Hospital in 2011 is currently a Professor in the Department of Pathology and Forensic Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, where he also developed a project in collaboration with the Departments of Genetics and Surgery. The current research projects involve investigation of the PTEN gene in prostate cancer and genomic analyzes in gliobalstoma and ovarian cancer. Research Productivity Grant Level PQ-1B. (Source: Lattes Curriculum)
- Characterization of the genetic mechanisms leading to immune evasion in the tumor microenvironment of prostate cancer, AP.R
Abstract
Immunotherapy has improved patient survival in many types of cancer, but in prostate cancer (PCa) initial results with immunotherapy have been disappointing. This tumor is considered immunologically "cold" and unable to generate an effective T-cell response against cancer cells. However, a small but significant percentage of patients with PCa do respond to immunotherapy for reasons that...
- Investigation of clinically useful genomic biomarkers in prostate cancer, AP.R
Abstract
Prostate cancer is characterized by a high incidence, great variation in the length of the latent period and uncertainty in the outcome. Moreover, blood PSA screening has resulted in over-diagnosis, so that many patients have clinically insignificant disease. Currently, treatment at first diagnosis is based on predictive nomograms, which integrate detailed histopathology with clinical d...
- The role of PTEN gene loss in facilitating the inflammatory response in prostate cancer, BP.DR
Abstract
Prostate cancer (PCa) is the sixth most common type of cancer in the world and is also the most prevalent in men. Our preliminary data showed that there is increased expression of STAT1 and decreased STAT3 expression in PCa tumors with deletion of the PTEN gene. Since the STAT transcription factor family is involved in modulating immune response, this observation suggests that the infl...
- The role of PTEN in STAT1 and STAT3 mediated inflammatory response in prostate cancer, BE.EP.DR
Abstract
We evaluated 493 PCa cases from the Genomic Data Commons cohort using aCGH and RNAseq data through an in silico analysis and found that 124 from 449 genes related to immune and inflammatory responses were differentially expressed between PTEN loss (n=104) versus PTEN intact (n=398) cases. We have demonstrated that the 124 differentially expressed genes were associated with type I and II...
| 1 / 1 | Ongoing research grants |
| 1 / 1 | Completed research grants |
| 1 / 1 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 4 / 4 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 4 |
| Citations | 12 |
| Cit./Article | 3.0 |
| Data from Web of Science | |
VIDOTTO, THIAGO; TIEZZI, DANIEL GUIMARAES; SQUIRE, JEREMY A.. Distinct subtypes of genomic PTEN deletion size influence the landscape of aneuploidy and outcome in prostate cancer. MOLECULAR CYTOGENETICS, v. 11, JAN 3 2018. Web of Science Citations: 7. (15/22785-5, 15/09111-5, 16/02730-4)
HARMON, STEPHANIE A.; PATEL, PALAK G.; SANFORD, THOMAS H.; CAVEN, ISABELLE; ISEMAN, RACHAEL; VIDOTTO, THIAGO; PICANCO, CLARISSA; SQUIRE, JEREMY A.; MASOUDI, SAMIRA; MEHRALIVAND, SHERIF; et al. High throughput assessment of biomarkers in tissue microarrays using artificial intelligence: PTEN loss as a proof-of-principle in multi-center prostate cancer cohorts. MODERN PATHOLOGY, SEP 2020. Web of Science Citations: 0. (15/22785-5, 15/09111-5, 17/08614-9)
VIDOTTO, THIAGO; MELO, CAMILA MORAIS; CASTELLI, ERICK; KOTI, MADHURI; DOS REIS, RODOLFO BORGES; SQUIRE, JEREMY A.. Emerging role of PTEN loss in evasion of the immune response to tumours. BRITISH JOURNAL OF CANCER, v. 122, n. 12, APR 2020. Web of Science Citations: 1. (15/22785-5, 15/09111-5, 17/08614-9)
YOSHIMOTO, MAISA; LUDKOVSKI, OLGA; GOOD, JENNIFER; PEREIRA, CIRO; GOODING, ROBERT J.; MCGOWAN-JORDAN, JEAN; BOAG, ALEXANDER; EVANS, ANDREW; TSAO, MING-SOUND; NUIN, PAULO; et al. Use of multicolor fluorescence in situ hybridization to detect deletions in clinical tissue sections. LABORATORY INVESTIGATION, v. 98, n. 4, p. 403-413, APR 2018. Web of Science Citations: 4. (15/09111-5)