Abstract
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm cytogenetically characterized by the presence of the Philadelfia (Ph) chromosome and molecularly by the appearance of the BCR-ABL1 neogene that encodes the Bcr-Abl oncoprotein with constitutive tyrosine kinase (TK) activity. Bcr-Abl expression promotes myeloproliferation, decreased hematopoietic cell adhesion to the medullary…