CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences from the Federal University of Santa Catarina (2007), she worked with cellular and molecular biology of the protozoan Trypanosoma rangeli. He completed his PhD at the Federal University of São Paulo (2008-2013), studying gene regulation and protein expression during the metacyclogenesis of Trypanosoma cruzi. During a sandwich period at the University of Texas at El Paso (2011-2012), he studied the secretion pathways of T. cruzi, characterizing its protein and nucleic acid content. He was a postdoctoral fellow at the MRC Center for Molecular Bacteriology and Infection, Imperial College London (2013-2015), where he studied the T3SS of Salmonella Typhimurium and the role of effector proteins in host cell modulation. He was a researcher at the Institute of Chemistry of the University of São Paulo (2016-2018), where he identified the function of T6SS from Xanthomonas citri and T4SS from Stenotrophomonas maltophilia. In 2018, he started his research group (www.bayersantoslab.com) at the Institute of Biomedical Sciences of the University of São Paulo with the help of the Jovem Pesquisador FAPESP program. He is interested in mechanisms of bacterial antagonism and (micro)biological conflicts. (Source: Lattes Curriculum)
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Bacterial secretion systems are versatile structures that secrete proteins and DNA in the extracellular medium or into prokaryotic and eukaryotic cells. Many pathogenic bacteria rely on secretion systems to modulate hosts responses or to defend themselves against competing organisms and predators. The type VI secretion system (T6SS) is present in several animal and plant pathogens. Seroty…
Bacteria developed different mechanisms of antagonism, either independent or dependent of contact between cells, to compete for resources in microbial communities. The Type VI Secretion System (T6SS) is a contact dependent antagonic mechanism, which consists of a contractile nanomachine capable of injecting toxic effectors into target cells. The T6SS effectors present a broad spectrum of …
The type VI secretion system (T6SS) is a protein complex that injects effector proteins into several cell types, including rival bacteria and eukaryotic cells. This pool of effectors represents a reservoir of proteins with a wide range of biochemical activities. Antibacterial effectors are natural antimicrobials, and effectors with anti-eukaryotic activities act against environmental pred…
Salmonella spp. encode five type VI secretion systems (T6SS) in different pathogenicity islands. These systems translocate effector proteins into target cells, which can be either eukaryotic or prokaryotic. Hcps (hemolysin-coregulated proteins) are components of T6SS and have several functions. The main one is structural, in which hexamers of Hcps form the tube that is ejected towards the…
The type 6 secretion system (T6SS) is an antibacterial weapon that injects toxic effectors into either eukaryotic or prokaryotic cells via cell-to-cell contact. The T6SS effectors have a wide range of biochemical activities and confer a competitive advantage to the bacteria that produce them, causing growth inhibition and/or death of target cells. Salmonella enterica is one of the species…
Bacteria live in polymicrobial communities and constantly compete for resources. Gram-negative species such as Salmonella sp. encode a type VI secretion system (T6SS, which is a contractile apparatus formed by 13 proteins capable of injecting toxic proteins (effectors) into competing bacteria, inducing their death. The genus Salmonella encodes five phylogenetically distinct T6SS from diff…
(Only some records are available in English at this moment)
Many pathogenic bacteria rely on secretion systems to modulate host responses. The type VI secretion system (T6SS) is present in several animal and plant pathogens. Serotypes of Salmonella enterica comprise facultative intracellular Gram-negative bacteria responsible for causing infections in vertebrates. Salmonella Typhimurium encodes a T6SS in the pathogenicity island SPI-6 and deletion…
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| 3 / 3 | Ongoing scholarships in Brazil |
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| 1 / 1 | Completed scholarships abroad |
| 15 / 15 | All research grants and scholarships |
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