Abstract
RANKL system consists of a triad of proteins: the receptor activator of NFkB (RANK), its ligand RANKL and the decoy receptor osteoprotegerin (OPG). This unique system of two receptors and one ligand is described in T cell and dendritic cell communication, development of mammary glands and bone metabolism. OPG is a biomarker related to cardiovascular diseases events, high rate of mortality…