CV Lattes
Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Abi - Ciências Biológicas from Universidade de São Paulo (2019) and graduation at Ciências Biológicas - Ênfase em Biologia Molecular e Tecnológica from Universidade de São Paulo (2018). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: sf1, splicing and spliceossomo. (Source: Lattes Curriculum)
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Mutations of proteins components which form the spliceosome, such as U2AF35, ZRSR2, SRSF2, SF3A1, SF3B1, PRP40B, U2AF65, SRSF1 and SF1, are related with tumorigenesis in myeloid and lymphoid lineages. The SF1 gene encodes a protein that acts in the formation of the splicing complex E/A, recognizing the branch point of the intron in the pre-RNA, allowing the interation with the U2AF65 fact…
Splicing Factor 1 is located on chromosome 11q13. The protein contains an ULM motif, a coiled-coil and KH-QUA2 domains, followed by a zinc knuckle and a proline rich region. SF1 recognizes the branch point sequence within the intron, interacts with the U2AF subunits and signals the first steps of spliceosome assembly. In the alternative splicing, SF1 selectively regulates a subset of intr…
| 1 / 1 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 2 / 2 | All Scholarships |
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