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Luís Guilherme Mansor Basso

CV Lattes ResearcherID ORCID


Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Luis Basso received a Bachelor's degree in Physics in 2006 and an M.Sc. (2009) and a Ph.D. (2014) degree in Physics from the Sao Carlos Physics Institute (IFSC), University of São Paulo (USP). In his scientific initiation, he worked on the investigation of the magnetic interactions in copper-peptide single crystals by electron spin resonance (ESR). As a graduate student, he studied the effects of antimalarial drugs on the structural dynamics and physicochemical properties of biological membrane model systems using a combination of ESR and calorimetric techniques. In his Ph.D. project, he investigated the membrane fusion mechanism played by membrane-active peptides belonging to the fusion domain of the Spike glycoprotein from a coronavirus (CoV) that caused severe acute respiratory syndrome (SARS). During this period, he helped to consolidate in Brazil a pulsed ESR technique called Double Electron-Electron Resonance (DEER) in combination with Site-Directed Spin Labeling (SDSL) for structural biology studies. He has also spent one year in Prof. Benoît Roux's group at the University of Chicago working on the development of polarizable force fields for anionic phospholipids and on the application of advanced free-energy molecular dynamics simulation techniques to study the folding of membranLuis Basso received a Bachelor's degree in Physics in 2006 and an M.Sc. (2009) and a Ph.D. (2014) degree in Physics from the Sao Carlos Physics Institute (IFSC), University of São Paulo (USP). In his scientific initiation, he worked on the investigation of the magnetic interactions in copper-peptide single crystals by electron spin resonance (ESR). As a graduate student, he studied the effects of antimalarial drugs on the structural dynamics and physicochemical properties of biological membrane model systems using a combination of ESR and calorimetric techniques. In his Ph.D. project, he investigated the membrane fusion mechanism played by membrane-active peptides belonging to the fusion domain of the Spike glycoprotein from a coronavirus (CoV) that caused severe acute respiratory syndrome (SARS). During this period, he helped to consolidate in Brazil a pulsed ESR technique called Double Electron-Electron Resonance (DEER) in combination with Site-Directed Spin Labeling (SDSL) for structural biology studies. He has also spent one year in Prof. Benoît Roux's group at the University of Chicago working on the development of polarizable force fields for anionic phospholipids and on the application of advanced free-energy molecular dynamics simulation techniques to study the folding of membrane-embedded potassium channels. In 2014, he started to work as a postdoctoral fellow in the Physics Department of the Faculty of Philosophy, Sciences, and Letterse-embedded potassium channels. In 2014, he started to work as a postdoctoral fellow in the Physics Department of the Faculty of Philosophy, Sciences, and Letters at Ribeirão Preto (FFCLRP/USP) to elucidate the molecular mechanism used by viral membrane peptides to trigger fusion of the viral and cellular membranes. Luis has also applied other pulsed ESR techniques, such as Electron Spin Echo Envelope Modulation (ESEEM) and Hyperfine Sublevel Spectroscopy (HYSCORE), to investigate the structural details of biological macromolecules. From 2017 to 2019, as a postdoctoral fellow at the University of California, San Diego (UCSD), he used state-of-the-art solution-state and solid-state nuclear magnetic resonance (NMR) techniques to resolve the tridimensional structure of membrane proteins embedded in lipid bilayers. Under the supervision of Prof. Dr. Stanley Opella, he also worked on the development of more native and physiologically relevant biological membrane systems for solid-state NMR of magnetically oriented membrane protein/lipid bilayer samples. He is currently an Associate Professor in the Laboratory of Physical Sciences (LCFIS) at the State University of Northern Rio de Janeiro Darcy Ribeiro (UENF). (Source: Lattes Curriculum)

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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (14)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BASSO, LUIS G. M.; VICENTE, EDUARDO F.; CRUSCA, JR., EDSON; CILLI, EDUARDO M.; COSTA-FILHO, ANTONIO J.. SARS-CoV fusion peptides induce membrane surface ordering and curvature. SCIENTIFIC REPORTS, v. 6, . Web of Science Citations: 9. (09/10997-7, 10/12953-4, 08/57910-0, 14/00206-0, 15/18390-5)

MICHELETTO, MARIANA C.; MENDES, LUIS F. S.; BASSO, LUIS G. M.; FONSECA-MALDONADO, RAQUEL G.; COSTA-FILHO, ANTONIO J.. Lipid membranes and acyl-CoA esters promote opposing effects on acyl-CoA binding protein structure and stability. International Journal of Biological Macromolecules, v. 102, p. 284-293, . Web of Science Citations: 2. (15/50366-7, 15/18390-5, 14/00206-0, 12/13309-7)

VIEIRA, ERNANNI D.; BASSO, LUIS G. M.; COSTA-FILHO, ANTONIO J.. Non-linear van't Hoff behavior in pulmonary surfactant model membranes. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1859, n. 6, p. 1133-1143, . Web of Science Citations: 3. (15/18390-5, 14/00206-0, 10/17662-8)

FELIZATTI, ANA P.; ZERAIK, ANA E.; BASSO, LUIS G. M.; KUMAGAI, PATRICIA S.; LOPES, JOSE L. S.; WALLACE, B. A.; ARAUJO, ANA P. U.; DEMARCO, RICARDO. Interactions of amphipathic alpha-helical MEG proteins from Schistosoma mansoni with membranes. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1862, n. 3, . Web of Science Citations: 0. (14/09361-9, 14/00206-0, 18/19546-7, 15/50347-2)

VICENTE, EDUARDO F.; BASSO, LUIS GUILHERME M.; CESPEDES, GRAZIELY F.; LORENZON, ESTEBAN N.; CASTRO, MARIANA S.; MENDES-GIANNINI, MARIA JOSE S.; JOSE COSTA-FILHO, ANTONIO; CILLI, EDUARDO M.. Dynamics and Conformational Studies of TOAC Spin Labeled Analogues of Ctx(Ile(21))-Ha Peptide from Hypsiboas albopunctatus. PLoS One, v. 8, n. 4, . Web of Science Citations: 13. (09/10997-7, 10/06526-6, 10/17662-8)

BARROSO, RAFAEL P.; BASSO, LUIS G. M.; COSTA-FILHO, ANTONIO J.. Interactions of the antimalarial amodiaquine with lipid model membranes. Chemistry and Physics of Lipids, v. 186, p. 68-78, . Web of Science Citations: 5. (12/20367-3, 10/17662-8)

VICENTE, EDUARDO F.; SAHU, INDRA D.; CRUSCA, JR., EDSON; BASSO, LUIS G. M.; MUNTE, CLAUDIA E.; COSTA-FILHO, ANTONIO J.; LORIGAN, GARY A.; CILLI, EDUARDO M.. HsDHODH Microdomain-Membrane Interactions Influenced by the Lipid Composition. Journal of Physical Chemistry B, v. 121, n. 49, p. 11085-11095, . (15/18390-5, 10/06526-6, 14/00206-0, 10/12953-4)

BASSO, LUIS G. M.; RODRIGUES, RENATA Z.; NAAL, ROSE M. Z. G.; COSTA-FILHO, ANTONIO J.. Effects of the antimalarial drug primaquine on the dynamic structure of lipid model membranes. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1808, n. 1, p. 55-64, . (08/57910-0)

CRUSCA, JR., EDSON; MANSOR BASSO, LUIS GUILHERME; ALTEI, WANESSA FERNANDA; MARCHETTO, REINALDO. Biophysical characterization and antitumor activity of synthetic Pantinin peptides from scorpion's venom. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1860, n. 11, p. 2155-2165, . (14/18747-8, 14/00206-0)

SCORTECCI, JESSICA F.; SERRAO, VITOR HUGO B.; FERNANDES, ADRIANO F.; BASSO, LUIS G. M.; GUTIERREZ, RAISSA F.; ARAUJO, ANA PAULA U.; NETO, MARIO O.; THIEMANN, OTAVIO H.. Initial steps in selenocysteine biosynthesis: The interaction between selenocysteine lyase and selenophosphate synthetase. International Journal of Biological Macromolecules, v. 156, p. 18-26, . (12/23730-1, 16/20977-7, 14/00206-0, 13/17791-0, 14/16005-4)

BASSO, LUIS G. M.; VICENTE, EDUARDO F.; CRUSCA, JR., EDSON; CILLI, EDUARDO M.; COSTA-FILHO, ANTONIO J.. SARS-CoV fusion peptides induce membrane surface ordering and curvature. SCIENTIFIC REPORTS, v. 6, . (15/18390-5, 14/00206-0, 09/10997-7, 10/12953-4, 08/57910-0)

VIEIRA, ERNANNI D.; BASSO, LUIS G. M.; COSTA-FILHO, ANTONIO J.. Non-linear van't Hoff behavior in pulmonary surfactant model membranes. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1859, n. 6, p. 1133-1143, . (15/18390-5, 14/00206-0, 10/17662-8)

MANSOR BASSO, LUIS GUILHERME; ZERAIK, ANA ELIZA; FELIZATTI, ANA PAULA; COSTA-FILHO, ANTONIO JOSE. Membranotropic and biological activities of the membrane fusion peptides from SARS-CoV spike glycoprotein: The importance of the complete internal fusion peptide domain. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1863, n. 11, . (08/57910-0, 15/50366-7, 14/00206-0, 15/18390-5)

BALASCO SERRAO, VITOR HUGO; DE FREITAS FERNANDES, ADRIANO; MANSOR BASSO, LUIS GUILHERME; SCORTECCI, JESSICA FERNANDES; CRUSCA JUNIOR, EDSON; LOPES CORNELIO, MARINONIO; MONSON DE SOUZA, BIBIANA; PALMA, MARIO SERGIO; DE OLIVEIRA NETO, MARIO; THIEMANN, OTAVIO HENRIQUE. The Specific Elongation Factor to Selenocysteine Incorporation in Escherichia coli: Unique tRNA(Sec) Recognition and its Interactions. Journal of Molecular Biology, v. 433, n. 23, . (13/17791-0, 14/00206-0, 12/15777-8, 12/23730-1, 14/16005-4, 98/14138-2)

FELIZATTI, ANA P.; ZERAIK, ANA E.; BASSO, LUIS G. M.; KUMAGAI, PATRICIA S.; LOPES, JOSE L. S.; WALLACE, B. A.; ARAUJO, ANA P. U.; DEMARCO, RICARDO. Interactions of amphipathic alpha-helical MEG proteins from Schistosoma mansoni with membranes. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1862, n. 3, . (14/09361-9, 14/00206-0, 18/19546-7, 15/50347-2)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BASSO, Luís Guilherme Mansor. Interações de fármacos anti-malária com modelos de membrana. Dissertação (Mestrado) -  Instituto de Física de São Carlos.  Universidade de São Paulo (USP).  São Carlos.  (06/58479-6

BASSO, Luís Guilherme Mansor. Interações com membranas de peptídeos de fusão da glicoproteína S do SARS-CoV. Tese (Doutorado) -  Instituto de Física de São Carlos.  Universidade de São Paulo (USP).  São Carlos.  (09/10997-7

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