- Research Grants
bachelor's at EDucação Física from Universidade Estadual de Maringá (2010). (Source: Lattes Curriculum)
Thiazolidinediones (TZDs), synthetic ligands for the nuclear receptor PPAR³, have been largely used in the treatment of metabolic diseases such as insulin resistance, dyslipidemias and metabolic syndrome. These drugs were shown to improve glucose homeostasis by promoting fat redistribution from visceral to subcutaneous depots, adiponectin secretion and by reducing lipemia, lipotoxicity,...
In this project, we will continue to collect human adipocyte samples and generate RNA-seq and histone modification ChIP-seq libraries to assess genome-wide transcriptional and epigenomic states. We have identified key cis-regulatory elements with altered activity in the IR state and have determined the candidate transcription factors (TFs) that bind them. We will validate the importanc...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|