Isabela de Paula Leirão

• Abstract

  Rhythmogenic respiratory neurons on the ventral surface of the medulla, located in the pre-Bötzinger complex (pre-BötC), constitute the primary inspiratory oscillator and are responsible for generating the respiratory rhythm. In situations of reduced O2 (hypoxia) and/or increased CO2 (hypercapnia), the pre-BötC is stimulated to promote an increase in the respiratory frequency. In these si…

  Control of breathing pattern: interactions between respiratory oscillators, BP.DR

• Abstract

  Breathing is an automatic homeostatic process, primarily coordinated by a complex neural network located in the brainstem. The functioning of this neural network is modified during stimuli that promote alterations in the partial pressure of the blood gases. In hypercapnia (increase in PaCO2), chemosensory cells located in the brainstem, which are directly connected to the respiratory neur…

  Functional interaction between raphe and retrotrapezoid nuclei for the control of breathing pattern and hypercapnic ventilatory response in rats, BP.MS

• Abstract

  In the nervous system, serotonin (5-HT) is involved in several functions, including circadian rhythms, diet, emotional state, control of sleep and respiratory control. Respiration is a rhythmic process initiated in the central nervous system (CNS). At rest, expiration is a passive process, however, mammals recruit expiratory muscles (such as abdominal) under conditions of increased respir…

  Medullary raphe and active expiration during hypercapnia: role of serotonergic modulation, BP.IC

(Only some records are available in English at this moment)

• Abstract

  Rhythmogenic neurons of the pre-Bötzinger complex (preBötC), located in the ventral medulla, constitute the primary inspiratory oscillator that generates the respiratory rhythm. A second respiratory oscillator was described rostral to the preBötC in the lateral parafacial region (pFL), recruited during conditions of high respiratory drive to generate rhythmic expiratory contractions in th…

  Control of abdominal expiratory activity by the preBötzinger complex, BE.EP.DR