Bachelor of Biotechnological Engineering from Universidade Estadual Paulista "Julio de Mesquita Filho" (UNESP). Master in Biosciences and Biotechnology - focus on Bioagents and Biotechnology applied to pharmacy at the School of Pharmaceutical Sciences of Ribeirão Preto - University of São Paulo (USP). Currently a PhD student at the postgraduate program in 'Clinical Oncology, Stem Cells and Cell Therapy' linked to the Faculty of Medicine of Ribeirão Preto (FMRP) and the Hemocentro Foundation of Ribeirão Preto. (Source: Lattes Curriculum)
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Therapies using CAR cells are available via autologous processes, as T cells require high HLA compatibility and allogeneic therapies have a high chance of developing graft-versus-host disease. Allogeneic therapeutic processes (off-the-shelf) allow immediate availability of cells, reducing patient waiting time. The generation of NK-CAR cells is an alternative, due to its high cytotoxic cap…
Studies with the use of modified T lymphocytes with Chemical Antigen Receptors (CAR) present expressive results in the treatment of leukemias and lymphomas. Lentivirus are widely used with vectors of gene modification in this type of therapy, with the reason of their advantages, such as cell genome stability, transduction efficiency and safety. Monolayer cultivation is limited because it …
The serotoninergic activity on 5-HT1A receptors in the ventral hippocampus in the regulation of different types of anxiety is still unknown yet. A previous study in our laboratory using the elevated T maze (ETM) showed that activation of 5 -HT1A receptors in HV decreased avoidance behavior of animals without affecting the escape responses, similar to what was observed as a result of midaz…
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