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Opher Gileadi

CV Lattes ResearcherID

Universidade Estadual de Campinas (UNICAMP). Centro de Biologia Molecular e Engenharia Genética (CBMEG)  (Institutional affiliation for the last research proposal)
Birthplace: Israel

Opher Gileadi obtained his B.Sc. in Biology (1983) and PhD in Biochemistry at the Hebrew University (1989) and was then a postdoctoral fellow at Stanford University Medical School. Subsequently he led a research group at the Weizmann Institute of Science. Since 2004 he has been at the Structural Genomics Consortium (SGC) at the University of Oxford, first as head of the Bioytechnology group, then as Principal Investigator of the Genome Integrity & Repair Group. Opher studied the biochemical basis of gene expression and DNA repair using a variety of approaches, including the analysis of differential mRNA in human trophoblast cells, transcription factors studies using purified systems and genetics of yeast, and only analyzes molecule of protein: DNA interactions. The SGC (Structural Genomics Consortium), Opher established the group of biotechnology, developing high-yield production methods (high-throughput) of human proteins for crystallization. He now leads the Genome Integrity Group, which studies proteins and DNA repair proteins associated with human genetic disease. Recent work includes helicases structures RecQ DNA endonucleases and DNA repair cross-link and biochemical characterization of mutant genes congenital syndrome Carpenter and Dyserythropoietic congenital anemia. It is currently also developing methods to intervene in DNA repair using small molecules, such as new inhibitors of the Bloom DNA helicase. In July 2015, Opher has relocated to Brazil to head the SGC Kinase Chemical Biology Center at the State University of Campinas (UNICAMP). (Source: Lattes Curriculum)

News published in Agência FAPESP Newsletter about the researcher
Articles published in other media outlets (1 total):
Mindzilla (Reino Unido): Chemical Probe can Regulate Signalling Pathway and Block Cell Invasion by Arboviruses (18/Mar/2019)
Research grants
Scholarships in Brazil
FAPESP support in numbers * Updated July 31, 2021
Total / Available in English
Most frequent collaborators in research granted by FAPESP
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Keywords used by the researcher
Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Data from Web of Science

WELLS, CARROW I.; VASTA, JAMES D.; CORONA, CESEAR R.; WILKINSON, JENNIFER; ZIMPRICH, CHAD A.; INGOLD, MORGAN R.; PICKETT, JULIE E.; DREWRY, DAVID H.; PUGH, KATHRYN M.; SCHWINN, MARIE K.; et al. Quantifying CDK inhibitor selectivity in live cells. NATURE COMMUNICATIONS, v. 11, n. 1, . Web of Science Citations: 0. (14/50897-0, 13/50724-5, 16/17469-0)

HERNEISEN, ALICE L.; SIDIK, SAIMA M.; MARKUS, BENEDIKT M.; DREWRY, DAVID H.; ZUERCHER, WILLIAM J.; LOURIDO, SEBASTIAN. Identifying the Target of an Antiparasitic Compound in Toxoplasma Using Thermal Proteome Profiling. ACS Chemical Biology, v. 15, n. 7, p. 1801-1807, . Web of Science Citations: 0. (13/50724-5, 16/17469-0)

WELLS, CARROW; COUNAGO, RAFAEL M.; LIMAS, JUANITA C.; ALMEIDA, TUANNY L.; COOK, JEANETTE GOWEN; DREWRY, DAVID H.; ELKINS, JONATHAN M.; GILEADI, OPHER; KAPADIA, NIRAV R.; LORENTE-MACIAS, ALVARO; et al. SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K. ACS Medicinal Chemistry Letters, v. 11, n. 3, p. 340-345, . Web of Science Citations: 0. (14/50897-0, 13/50724-5, 16/17469-0)

AGAJANIAN, MEGAN J.; WALKER, MATTHEW P.; AXTMAN, ALISON D.; RUELA-DE-SOUSA, ROBERTA R.; SERAFIN, D. STEPHEN; RABINOWITZ, ALEX D.; GRAHAM, DAVID M.; RYAN, MEAGAN B.; TAMIR, TIGIST; NAKAMICHI, YUKO; et al. WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. CELL REPORTS, v. 26, n. 1, p. 79+, . Web of Science Citations: 2. (13/50724-5, 16/17469-0)

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