CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Educação Física from Universidade Federal de Viçosa (2008), master's at General Biology from Universidade Federal de Viçosa (2010) and doctorate at Fitness from Universidade de São Paulo (2015). (Source: Lattes Curriculum)
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Heart has an extraordinary capacity to cope with several stress conditions, including metabolic and hemodynamic changes. This requires an adaptive response that promotes molecular and structural changes in the heart. Initially, this response is compensatory; however, sustained activation of the cardiac remodeling program impairs heart functionality. Although there is a huge interest in th…
Cardiomyopathies are among the leading causes of death worldwide. Independently of etiology, cardiomyopathies are associated with a cardiac structural and molecular remodeling. Initially, this response is compensatory; however, sustained activation of the cardiac remodeling process is deleterious and compromises cardiac function. Although the molecular mechanisms underlying pathological r…
Brown adipose tissue is specialized in heat production. This biological phenomenon, known as thermogenesis, happens in futile energy-consuming cycles that uncouple metabolic oxidation from ATP production. For instance, the expression of the uncoupling protein 1 (UCP1) allows the proton gradient generated during oxidative phosphorylation to dissipate through the mitochondrial inner membran…
Cancer is a major cause of death worldwide. Although the immune system provides a critical defense against cancer cells, many tumors evolve to evade eradication by generating an immunosuppressive microenvironment that prevents immune cells activation, infiltration and cytotoxicity. However, recent findings suggest that regular physical activity inhibits cancer progression through an immun…
Obesity is a major public health problem worldwide. The global prevalence of obesity has more than doubled over the past four decades, affecting more than a billion people. The prevalence of obesity for most countries has been increasing since 1980s. Beyond this, obesity has been declared a disease per se that impairs quality of life and reduces life expectancy. Notably, two-thirds of obe…
Physical inactivity is considered one of the main factors for the increase in the incidence of chronic-degenerative diseases. The benefits of physical exercise are directly linked to the improvement of mitochondrial bioenergetic input. Recently, we demonstrated that the optimization of cardiac mitochondrial metabolism in physical exercise is associated to the degree of mitochondrial plast…
(Only some records are available in English at this moment)
Doxorubicin is an anthracycline widely used to treat different types of cancer including leukemia, lymphomas and breast cancer. However, it has high risk of cardiotoxicity since it accumulates and negatively affects cardiac mitochondrial proteostasis and bioenergetics. Disruption of mitochondrial proteostasis triggers a conserved signaling pathway termed mitochondrial unfolded protein res…