Biomedical Sciences BSc from Universidade de São Paulo (2017). (Source: Lattes Curriculum)
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Leishmania is an obligate intracellular parasite in the mammalian host, infecting phagocytic cells of the immune system. Inside the macrophage, the amastigote form is capable of subverting the hostile environment of the phagolysosome modulating host gene expression for its survival. L-arginine is a common substrate for both Nitric Oxide (NO) or polyamines production by macrophage enzymes …
The establishment of Leishmania infection in macrophages depends on the subversion of the immune response of this host cell to the parasite. One of these subversion mechanisms consists in the modulation of the L-arginine metabolism, a common substrate of nitric oxide (NO) and polyamines production pathways. This regulation directly influences the survival of the amastigote in the phagolys…
Metabolomic is emerging as an important tool to characterize macrophage phenotype, that, combined to genetic approaches, allows deciphering gene expression regulation in its ultimate phenotype, the metabolism. Metabolic rewiring during Leishmania infection was extensively studied in murine macrophages, but the differences to human immunology are increasingly being studied. Leishmania poss…
| 2 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
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