Abstract
Leishmania is an obligate intracellular parasite in the mammalian host, infecting phagocytic cells of the immune system. Inside the macrophage, the amastigote form is capable of subverting the hostile environment of the phagolysosome modulating host gene expression for its survival. L-arginine is a common substrate for both Nitric Oxide (NO) or polyamines production by macrophage enzymes …