Holds a bachelor's degree in biological sciences - emphasis on biotechnology from the Universidade do Vale do Itajaí (2005). Received his PhD from the Department of Physiology and Biophysics, Institute of Biomedical Sciences of the University of São Paulo, where he was a FAPESP postdoctoral fellow investigating the effects of omega-3 fatty acids on energy metabolism (2011). Worked at the Technical University of Munich (TUM) investigating postprandial metabolic adaptations, using mass spectrometry to identify markers of phenotypic flexibility. At the French National Institute for Agricultural Research (INRA) he developed research in search of new metabolites of dietary monoterpenoids using in silico tools to predict the metabolism of xenobiotics and high resolution mass spectrometry. He is a professor in the Department of Food and Experimental Nutrition of the Faculty of Pharmaceutical Sciences of the University of São Paulo acting in the area of metabolomics in food and nutrition. (Source: Lattes Curriculum)
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We propose the execution of a clinical study conducted remotely, with minimally invasive, low-cost blood sampling techniques, whose execution is compatible with the limitations imposed by the COVID-19 pandemic. This study will serve as proof of feasibility of a remote clinical trial and will have as its central objective the investigation of the effects of D-limonene on postprandial inter…
The health effects of flavonoids and other bioactive compounds found in oranges have been studied for a long time. On the other hand, bioactive phytochemicals found in citrus such as d-limonene, have not yet been properly studied. Due to its antimicrobial activity, we believe that d-limonene can modulate the composition of intestinal microbiota, responsible for metabolizing bile acids. Bi…
Fish consumption has increased in recent decades, due to consumer interest in the positive health effects associated with the regular intake of this food, among other factors. Previous studies have described significant results in the acute consumption of fish products, favoring the reduction of triglycerides, total cholesterol, low-density lipoprotein, reduced insulin secretion, and incr…
Bile acids (BA) are amphipathic molecules derived from cholesterol catabolism, recently recognized as metabolic integrators, participating in the regulation of energy metabolism (including the inhibition of gluconeogenesis and stimulation of fatty acid ²-oxidation) and inflammation through hormone-like functions. Among the endogenous metabolites, BA are those whose plasma concentration sh…
D-limonene, found mainly in orange peel, is associated with several beneficial properties, including hypolipidemic, hypoglycemic and antimicrobial effects. Bile acids are cholesterol-derived molecules that are involved in the emulsification of dietary lipids, in addition to having endocrine effects, with the potential to modulate the metabolism of lipids and carbohydrates. Their metabolis…
Brazil is one of the largest producers and exporters of oranges and orange juice in the world. Among the by-products of this citrus chain, the essential oil of orange peel has great economic value. This oil contains high amounts of the monoterpene D-limonene, to which lipid-lowering effects are attributed, among several actions in different physiological processes. Despite the effects dem…
The incidence of chronic diseases associated with dyslipidemia and insulin resistance is a serious public health problem. In animal models, it has been shown that D-limonene, a monoterpene abundant in citrus fruits contributes to reduce the circulating concentrations of lipids and glucose. The mechanism by which monoterpenoids modulates intermediate metabolism has not yet been fully eluci…
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Omega-3 polyunsaturated fatty acids (n-3 PUFA) are associated with the prevention of insulin resistance. These molecules increase peroxisomal ²-oxidation of fatty acids (FA) and stimulate peroxisome proliferation in the liver through the activation of peroxisome proliferator activated receptors (PPAR). This project is based on the hypothesis that other than increasing peroxisomal FA ²-oxi…
| 1 / 1 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 7 / 7 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 13 / 13 | All research grants and scholarships |
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CV Lattes
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