bachelor's at Farmácia e Bioquímica from Universidade de São Paulo (2005) and doctorate at Physiology from Universidade de São Paulo (2010). , acting on the following subjects: desnutrição, desnutrição protéica, progenitores hematopoéticos, ciclo celular and hemopoese. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
How the microbiota communicates with the host and contributes to health is a key question for progress in this research field. Bacterial metabolites called short chain fatty acids (SCFAs), which are generated by fermentation of non-digestible carbohydrates, constitute a link between microbiota and host cells. Previous studies demonstrated that these metabolites regulate host metabolism an…
The Covid-19 pandemic has impacted public health dramatically in several countries. In this context, understanding the factors related to the serious forms of Covid-19 is essential for prevention and, possibly, treatment of patients. Recent studies show that the intestinal microbiota and its products play a fundamental role in respiratory infections by other viruses including respiratory …
Short chain fatty acids (SCFAs) are products derived from the intestinal microbiota, which are produced mainly by the fermentation of dietary fibers. Found in high concentrations in the colon, SCFAs exert important functions for the maintainance of intestinal homeostasis including providing energy for intestinal epithelial cells (IECs), regulating their proliferation and apoptosis and mod…
(Only some records are available in English at this moment)
The intestinal commensal microbiota, in a symbiotic relationship with the host, provides the necessary stimuli to promote the production of antimicrobial peptides, increased barrier function, and proliferation of Intestinal Epithelial Cells (IECs). This interaction, which can occur through the recognition of Pathogen-Associated Molecular Patterns (PAMPs) by Toll-Like Receptors (TLRs), is …
The intestinal microbiota plays a fundamental role in the modulation of hematopoiesis and consequently in the production of neutrophils. This modulation can occur due to microbial components or metabolites derived from the microbiota. Short-chain fatty acids (SCFAs), produced by the intestinal microbiota through the metabolism of non-digestible carbohydrates from the diet, are molecules t…
The balance between intestinal microbiota activity and its interactions with immune system is essential for maintenance of homeostasis and prevention of inflammatory diseases. The diet compositions are able to modulate microorganism's populations of microbiota and consequently its activity, through metabolites production that are recognized by epithelial and immune cells. Fermentation of …
(Only some records are available in English at this moment)
The regulation of the proliferation and differentiation of intestinal stem cells (SSIs) is crucial for intestinal homeostasis. These processes are, in part, regulated by microbiota signals, especially short-chain fatty acids (AGCCs), which induce Post-Translational Modifications (PTMs) including histone acetylation and crotonylation, which are important in the regulation of gene expressio…
The interaction between neutrophils and intestinal microbiota is important for homeostasis and dysbiosis, as occurring in Inflammatory Bowel Disease (IBD). Short-Chain Fatty Acids (SCFAs) are metabolites generated by commensal bacteria and promote immunomodulatory effects. These effects occur, in part, due to the ability of SCFAs to promote Post-Translational Modifications (PTMs) of histo…
Gastrointestinal symptoms during COVID-19 have been associated with a worse prognosis. Infection with the P.1 variant has a higher mortality rate when compared to ancestral virus infection. In addition, the influence of gastrointestinal disorders, such as dysbiosis of the intestinal microbiota on the physiopathogenesis of COVID-19, especially about the P.1 variant, remains unknown. The ob…
(Only some records are available in English at this moment)
Inulin, a non-digestible fiber, is fermented by gut bacteria that produce different metabolites including short-chain fatty acids (SCFAs), lactate, inositol-triphosphate and indoles, which impact on host's cells functions. While there is a lot of information available regarding the host-modulating effects of the main short-chain fatty acids (acetate, butyrate, and propionate) and their as…
Fermentation of inulin fiber is known to induce IL-22 production, enhancing barrier function and epithelial regeneration. Gamma-delta T cells in the gut produce IL-22 and interact directly with IECs through the Myd88 axis. Furthermore, gamma-delta cells can sense nutrients from the diet, reprogramming their activity depending on the diet composition. Although the inulin diet has shown eff…
The intestinal microbiota plays a key role in promoting hematopoiesis and generating immune cells. This modulation occurs directly by host-commensal species interaction or indirectly though metabolites derived from the microbial metabolism. Short-chain fatty acids (SCFAs) are some of these molecules that are produced from dietary fibers by gut bacteria. They mainly activate protein-couple…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 5 / 5 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 14 / 14 | Completed scholarships in Brazil |
| 11 / 11 | Completed scholarships abroad |
| 37 / 37 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID