bachelor's at Farmácia e Bioquímica from Universidade de São Paulo (2005) and doctorate at Physiology from Universidade de São Paulo (2010). , acting on the following subjects: desnutrição, desnutrição protéica, progenitores hematopoéticos, ciclo celular and hemopoese. (Source: Lattes Curriculum)
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Dietary fibers act directly on the crosstalk between components of the microbiota, immune system and intestinal epithelial cells. Its intake is generally associated with metabolic and immunological benefits for the host. Despite advances in the area, there are still a limited number of microbial molecules and their possible targets described in the literature. Furthermore, there is a lack…
The microbiota is essential in maintaining the body's homeostasis. Recent studies highlight the pervasive impact of the gut microbiota on physiology, including in the regulation of systemic metabolism, development and functions of the immune and nervous systems. In this context, axenic or germ-free mice are essential tools. These models represent currently the gold standard in the study o…
The Covid-19 pandemic has impacted public health dramatically in several countries. In this context, understanding the factors related to the serious forms of Covid-19 is essential for prevention and, possibly, treatment of patients. Recent studies show that the intestinal microbiota and its products play a fundamental role in respiratory infections by other viruses including respiratory …
How the microbiota communicates with the host and contributes to health is a key question for progress in this research field. Bacterial metabolites called short chain fatty acids (SCFAs), which are generated by fermentation of non-digestible carbohydrates, constitute a link between microbiota and host cells. Previous studies demonstrated that these metabolites regulate host metabolism an…
(Only some records are available in English at this moment)
The intestinal commensal microbiota, in a symbiotic relationship with the host, provides the necessary stimuli to promote the production of antimicrobial peptides, increased barrier function, and proliferation of Intestinal Epithelial Cells (IECs). This interaction, which can occur through the recognition of Pathogen-Associated Molecular Patterns (PAMPs) by Toll-Like Receptors (TLRs), is …
The intestinal microbiota plays a fundamental role in the modulation of hematopoiesis and consequently in the production of neutrophils. This modulation can occur due to microbial components or metabolites derived from the microbiota. Short-chain fatty acids (SCFAs), produced by the intestinal microbiota through the metabolism of non-digestible carbohydrates from the diet, are molecules t…
The regulation of the proliferation and differentiation of intestinal stem cells (SSIs) is crucial for intestinal homeostasis. These processes are, in part, regulated by microbiota signals, especially short-chain fatty acids (AGCCs), which induce Post-Translational Modifications (PTMs) including histone acetylation and crotonylation, which are important in the regulation of gene expressio…
(Only some records are available in English at this moment)
The interaction between neutrophils and intestinal microbiota is important for homeostasis and dysbiosis, as occurring in Inflammatory Bowel Disease (IBD). Short-Chain Fatty Acids (SCFAs) are metabolites generated by commensal bacteria and promote immunomodulatory effects. These effects occur, in part, due to the ability of SCFAs to promote Post-Translational Modifications (PTMs) of histo…
Short-Chain Fatty Acids (SCFAs) from the fermentation of fiber-rich diets by the intestinal microbiota play important modulatory functions in the intestinal epithelium. These metabolites regulate genes involved in the energy metabolism of Intestinal Epithelial Cells (IECs) by stimulating oxygen consumption and, consequently, the activation of Hypoxia-Inducible Factor (HIF). Several studie…
Colitis is a major Inflammatory Bowel Disease (IBD) and represent an important public health problem. The intestinal microbiota plays an important role in maintaining intestinal homeostasis and contributes to communication with host cells. During epithelial regeneration, Intestinal Stem Cells (ISCs), present in crypts, give rise to precursor cells. It is not yet well understood, how ISCs …
(Only some records are available in English at this moment)
Inulin, a non-digestible fiber, is fermented by gut bacteria that produce different metabolites including short-chain fatty acids (SCFAs), lactate, inositol-triphosphate and indoles, which impact on host's cells functions. While there is a lot of information available regarding the host-modulating effects of the main short-chain fatty acids (acetate, butyrate, and propionate) and their as…
Fermentation of inulin fiber is known to induce IL-22 production, enhancing barrier function and epithelial regeneration. Gamma-delta T cells in the gut produce IL-22 and interact directly with IECs through the Myd88 axis. Furthermore, gamma-delta cells can sense nutrients from the diet, reprogramming their activity depending on the diet composition. Although the inulin diet has shown eff…
The intestinal microbiota plays a key role in promoting hematopoiesis and generating immune cells. This modulation occurs directly by host-commensal species interaction or indirectly though metabolites derived from the microbial metabolism. Short-chain fatty acids (SCFAs) are some of these molecules that are produced from dietary fibers by gut bacteria. They mainly activate protein-couple…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 6 / 6 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 16 / 16 | Completed scholarships in Brazil |
| 11 / 11 | Completed scholarships abroad |
| 39 / 39 | All research grants and scholarships |
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CV Lattes
ORCID