graduation at Farmacia from Universidade Federal de Ouro Preto (1992), master's at Biochemistry from Universidade Estadual de Campinas (1995) and doctorate at Biochemistry from Universidade Estadual de Campinas (1999). Has experience in Biochemistry, focusing on cancer signal transduction. (Source: Lattes Curriculum)
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Stomach cancer is fifth in incidence and third in mortality worldwide. The leading cause of gastric carcinogenesis is infection with Helicobater pylori, a bacterium which infects almost half the human population. Differences in virulence strains, other environmental factors and patient (genetic) characteristics contribute to cancer progression among those individuals infected with H pylor…
Over the past decade, the groups led by Prof. Carmen Veríssima Ferreira and Prof. Maikel Peppelenbosch have explored signal transduction pathways in order to define the action mechanisms of antitumor candidates and for identifyng molecular targets related with the aggressiveness and resistance of tumor cells. In this context, we have investigated cell lines and biopsies of patients with p…
The progress of knowledge about the molecular basis of cancer, has reinforced the concept of this multifactorial disease. The challenge in the coming years is to develop strategies to understand the molecular framework of tumor cells, therapeutic approaches to establish "smart" and personalized therapy in order to increase efficiency, specificity and quality of life of patients. In this c…
Melanomas are extremely aggressive tumors that originate from mutations in melanocytes. The high metastatic potential of melanomas is the main obstacle for treatment efficacy. Recently, several studies highlighted the relevant role played by the tumor microenvironment in several processes associated with tumor development and progression. Among the components of the tumor microenvironmen…
Melanoma is defined as an aggressive type of cancer due to its high ability to develop metastases and low response to therapy. In recent decades its incidence has been increasing and by 2040, estimates predict an increase of 50% in the number of cases and 68% in the number of deaths. Usually the melanoma studies are based on 2D cell culture, however this model is not able to mimic importa…
Stomach cancer is fifth in incidence and third in mortality worldwide. Patients are often diagnosed late, with fewer therapeutic options and poorer survival. In this scenario, low molecular weight protein tyrosine phosphatase (LMWPTP) emerges as a target to increase therapeutic efficacy, as it participates in a molecular network responsible for providing some advantages for tumor cells th…
Melanomas are extremely aggressive tumors that originate from mutations in melanocytes. The high metastatic potential of melanomas is the main obstacle to treatment efficacy. Recently, several studies have increasingly pointed to the relevant role played by the microenvironment in various processes associated with tumor development and progression. Among the components of the tumor microe…
(Only some records are available in English at this moment)
One of the main challenges in targeted therapy and immunotherapy is the poor treatmentresponse, attributed to biochemical and physical barriers that protect tumor cells, enablingtheir continuous adaptation and survival. Among these barriers, the crosstalk between thetumor-associated extracellular matrix and hypoxia is crucial to inactivating immune systemcells, antitumoral compounds, and …
The success of cancer prevention and treatment involves efficiency diagnosis and therapy. Over the past years, the Prof. Ferreira-Halder and Prof. Peppelenbosch research groups have investigated cancer cells metabolism to clarify resistance and aggressiveness processes. It was found a correlation between resistance/aggressiveness in leukemia, prostate and colorectal cancer (CRC) and high …
| 9 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 37 / 26 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 1 | Completed scholarships abroad |
| 51 / 32 | All research grants and scholarships |
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CV Lattes
ORCID