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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Carmen Veríssima Ferreira in research grants and scholarships supported by FAPESP.
Over the past decade, the groups led by Prof. Carmen Veríssima Ferreira and Prof. Maikel Peppelenbosch have explored signal transduction pathways in order to define the action mechanisms of antitumor candidates and for identifyng molecular targets related with the aggressiveness and resistance of tumor cells. In this context, we have investigated cell lines and biopsies of patients with p…
The progress of knowledge about the molecular basis of cancer, has reinforced the concept of this multifactorial disease. The challenge in the coming years is to develop strategies to understand the molecular framework of tumor cells, therapeutic approaches to establish "smart" and personalized therapy in order to increase efficiency, specificity and quality of life of patients. In this c…
Melanoma is the most lethal type of skin cancer due to its high proliferative rate and capacity for metastasis. Additionally, this tumor displays low response to treatment, which in part is due to a high basal rate of autophagic flow. Therefore, the study of these cellular mechanisms and for the screening of compounds, the 3D culture models have been shown to be effective, as it allows gr…
About 15-20% of colorectal cancer cases progress to metastasis in other organs reducing the efficiency of current therapy regimens and reducing patient survival. In recent years, research groups have focused on the study of the contribution of Extracellular Vesicles (EVs) in the tumor process. EVs are no longer understood as reservoirs for unwanted proteins and have now been considered as…
Colorectal cancer is still top 3 in the cause of cancer death worldwide. The late diagnosis together with the resistance acquisition of this cancer, are responsible for the low efficiency of the therapeutic protocols available. Thus, more effective therapeutic strategies are desirable. To this end, the molecular knowledge of cancer biology and the use of cellular models with a complexity …
Tumor cells must assemble cellular components necessary for the synthesis of macromolecules (nucleotides, proteins, lipids) and much energy to double their genome and enlarge their biomass. To that end, tumors alter cellular metabolism to contribute to tumorigenesis and malignancy. The metabolic characteristics and pathways through which tumor cells acquire and replenish their metabolic n…
Despite the great progress in the development of cancer treatment protocols, the effectiveness of the therapy of several tumors is still a challenge, especially in metastatic cases. Over the last decade, our research group has explored signal transduction pathways for the understanding of tumor biology. Our studies are focused on the mechanisms and identification of molecular targets envi…
(Only some records are available in English at this moment)
The success of cancer prevention and treatment involves efficiency diagnosis and therapy. Over the past years, the Prof. Ferreira-Halder and Prof. Peppelenbosch research groups have investigated cancer cells metabolism to clarify resistance and aggressiveness processes. It was found a correlation between resistance/aggressiveness in leukemia, prostate and colorectal cancer (CRC) and high …
| 8 / 2 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 32 / 21 | Completed scholarships in Brazil |
| 3 / 1 | Completed scholarships abroad |
| 45 / 26 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 31 |
| Citations | 471 |
| Cit./Article | 15.2 |
| Data from Web of Science | |
DE JESUS, MARCELO BISPO; RADAIC, ALLAN; ZUHORN, INGE S.; DE PAULA, ENEIDA. Microemulsion extrusion technique: a new method to produce lipid nanoparticles. JOURNAL OF NANOPARTICLE RESEARCH, v. 15, n. 10, SEP 3 2013. Web of Science Citations: 7. (09/13110-3, 12/01038-9)
FARIA, ALESSANDRA V. S.; ANDRADE, SHEILA S.; REIJM, AGNES N.; SPAANDER, MANON C. W.; DE MAAT, MONIEK P. M.; PEPPELENBOSCH, MAIKEL P.; FERREIRA-HALDER, V, CARMEN; FUHLER, GWENNY M.. Targeting Tyrosine Phosphatases by 3-Bromopyruvate Overcomes Hyperactivation of Platelets from Gastrointestinal Cancer Patients. JOURNAL OF CLINICAL MEDICINE, v. 8, n. 7, JUL 2019. Web of Science Citations: 0. (17/08119-8, 18/00736-0, 15/20412-7)
FERREIRA-HALDER, CARMEN VERISSIMA; DE SOUSA FARIA, ALESSANDRA VALERIA; ANDRADE, SHEILA SIQUEIRA. Action and function of Faecalibacterium prausnitzii in health and disease. BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY, v. 31, n. 6, p. 643-648, DEC 2017. Web of Science Citations: 21. (16/14459-3, 15/20412-7)
MARUMOTO, ARIANE; MILANI, RENATO; DA SILVA, RODRIGO A.; DA COSTA FERNANDES, CELIO JUNIOR; GRANJEIRO, JOSE MAURO; FERREIRA, CARMEN V.; PEPPELENBOSCH, MAIKEL P.; ZAMBUZZI, WILLIAN F.. Phosphoproteome analysis reveals a critical role for hedgehog signalling in osteoblast morphological transitions. BONE, v. 103, p. 55-63, OCT 2017. Web of Science Citations: 14. (14/22689-3)
GONCALVES, PAOLA R.; ROCHA-BRITO, KARIN J. P.; FERNANDES, MARUSKA R. N.; ABRANTES, JULIA L.; DURAN, NELSON; FERREIRA-HALDER, CARMEN V.. Violacein induces death of RAS-mutated metastatic melanoma by impairing autophagy process. TUMOR BIOLOGY, v. 37, n. 10, p. 14049-14058, OCT 2016. Web of Science Citations: 4. (13/08896-3)
SIPOLI, CAROLINE CASAGRANDE; RADAIC, ALLAN; SANTANA, NATHALIA; DE JESUS, MARCELO BISPO; DE LA TORRE, LUCIMARA GAZIOLA. Chitosan nanoparticles produced with the gradual temperature decrease technique for sustained gene delivery. Biochemical Engineering Journal, v. 103, p. 114-121, NOV 15 2015. Web of Science Citations: 10. (12/01038-9)
CHAVES NETO, ANTONIO HERNANDES; MACHADO, DAISY; YANO, CLAUDIA LUMY; FERREIRA, CARMEN VERISSIMA. Antioxidant defense and apoptotic effectors in ascorbic acid and beta-glycerophosphate-induced osteoblastic differentiation. DEVELOPMENT GROWTH & DIFFERENTIATION, v. 53, n. 1, p. 88-96, JAN 2011. Web of Science Citations: 3.
MACHADO, DAISY; SHISHIDO, SILVIA M.; QUEIROZ, KARLA C. S.; OLIVEIRA, DIOGO N.; FARIA, ANA L. C.; CATHARINO, RODRIGO R.; SPEK, C. ARNOLD; FERREIRA, CARMEN V.. Irradiated Riboflavin Diminishes the Aggressiveness of Melanoma In Vitro and In Vivo. PLoS One, v. 8, n. 1, JAN 16 2013. Web of Science Citations: 15. (09/00144-7)
DE JESUS, MARCELO BISPO; FRACETO, LEONARDO FERNANDES; FLORENCIA MARTINI, MARIA; PICKHOLZ, MONICA; FERREIRA, CARMEN VERISSIMA; DE PAULA, ENEIDA. Non-inclusion complexes between riboflavin and cyclodextrins. Journal of Pharmacy and Pharmacology, v. 64, n. 6, p. 832-842, JUN 2012. Web of Science Citations: 20. (06/03838-1)
MILANI, RENATO; FERREIRA, CARMEN V.; GRANJEIRO, JOSE M.; PAREDES-GAMERO, EDGAR J.; SILVA, RODRIGO A.; JUSTO, GISELLE Z.; NADER, HELENA B.; GALEMBECK, EDUARDO; PEPPELENBOSCH, MAIKEL P.; AOYAMA, HIROSHI; et al. Phosphoproteome Reveals an Atlas of Protein Signaling Networks During Osteoblast Adhesion. Journal of Cellular Biochemistry, v. 109, n. 5, p. 957-966, APR 1 2010. Web of Science Citations: 27.
RUELA-DE-SOUSA, R. R.; FUHLER, G. M.; BLOM, N.; FERREIRA, C. V.; AOYAMA, H.; PEPPELENBOSCH, M. P.. Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy. CELL DEATH & DISEASE, v. 1, JAN 2010. Web of Science Citations: 81.
ZAMBUZZI, WILLIAN F.; FERREIRA, CARMEN V.; GRANJEIRO, JOSE M.; AOYAMA, HIROSHI. Biological behavior of pre- osteoblasts on natural hydroxyapatite: A study of signaling molecules from attachment to differentiation. Journal of Biomedical Materials Research Part A, v. 97A, n. 2, p. 193-200, MAY 2011. Web of Science Citations: 18.
ZAMBUZZI, WILLIAN FERNANDO; BRUNI-CARDOSO, ALEXANDRE; GRANJEIRO, JOSE MAURO; PEPPELENBOSCH, MAIKEL PETRUS; DE CARVALHO, HERNANDES FAUSTINO; AOYAMA, HIROSHI; FERREIRA, CARMEN VERISSIMA. On the Road to Understanding of the Osteoblast Adhesion: Cytoskeleton Organization Is Rearranged by Distinct Signaling Pathways. Journal of Cellular Biochemistry, v. 108, n. 1, p. 134-144, SEP 1 2009. Web of Science Citations: 28.
FERREIRA‚ C.V.; JUSTO‚ G.Z.; SOUZA‚ A.; QUEIROZ‚ K.; ZAMBUZZI‚ W.F.; AOYAMA‚ H.; PEPPELENBOSCH‚ M.P.. Natural compounds as a source of protein tyrosine phosphatase inhibitors: Application to the rational design of small-molecule derivatives. Biochimie, v. 88, n. 12, p. 1859-1873, 2006.
AUGUSTO, T. M.; BRUNI-CARDOSO, A.; DAMAS-SOUZA, D. M.; ZAMBUZZI, W. F.; KUEHNE, F.; LOURENCO, L. B.; FERREIRA, C. V.; CARVALHO, H. F.. Oestrogen imprinting causes nuclear changes in epithelial cells and overall inhibition of gene transcription and protein synthesis in rat ventral prostate. INTERNATIONAL JOURNAL OF ANDROLOGY, v. 33, n. 5, p. 675-685, OCT 2010. Web of Science Citations: 4. (05/02601-5)
CHAVES NETO, ANTONIO HERNANDES; YANO, CLAUDIA LUMY; PAREDES-GAMERO, EDGAR JULIAN; MACHADO, DAISY; JUSTO, GISELLE ZENKER; PEPPELENBOSCH, MAIKEL P.; FERREIRA, CARMEN VERISSIMA. Riboflavin and photoproducts in MC3T3-E1 differentiation. TOXICOLOGY IN VITRO, v. 24, n. 7, p. 1911-1919, OCT 2010. Web of Science Citations: 9.
CHAVES NETO, ANTONIO HERNANDES; QUEIROZ, KARLA CRISTIANA; MILANI, RENATO; PAREDES-GAMERO, EDGAR JULIAN; JUSTO, GISELLE ZENKER; PEPPELENBOSCH, MAIKEL P.; FERREIRA, CARMEN VERISSIMA. Profiling the Changes in Signaling Pathways in Ascorbic Acid/beta-Glycerophosphate-Induced Osteoblastic Differentiation. Journal of Cellular Biochemistry, v. 112, n. 1, p. 71-77, JAN 2011. Web of Science Citations: 7.
CORDEIRO, HELON GUIMARAES; DE SOUSA FARIA, ALESSANDRA VALERIA; FERREIRA-HALDER, CARMEN VERISSIMA. Vemurafenib downmodulates aggressiveness mediators of colorectal cancer (CRC): Low Molecular Weight Protein Tyrosine Phosphatase (LMWPTP), Protein Tyrosine Phosphatase 1B (PTP1B) and Transforming Growth Factor ss (TGF ss). Biological Chemistry, v. 401, n. 9, p. 1063-1069, AUG 2020. Web of Science Citations: 0. (17/08119-8, 15/20412-7)
FARIA, ALESSANDRA V. DE S.; AKYALA, ADAMU ISHAKU; PARIKH, KAUSHAL; BRUEGGEMANN, LOIS W.; SPEK, C. ARNOLD; CAO, WANLU; BRUNO, MARCO J.; BIJLSMA, MAARTEN F.; FUHLER, GWENNY M.; PEPPELENBOSCH, MAIKEL P.. Smoothened-dependent and -independent pathways in mammalian noncanonical Hedgehog signaling. Journal of Biological Chemistry, v. 294, n. 25, p. 9787-9798, JUN 21 2019. Web of Science Citations: 0. (18/00736-0)
FARIA, ALESSANDRA V. S.; ANDRADE, SHEILA S.; PEPPELENBOSCH, MAIKEL P.; FERREIRA-HALDER, CARMEN V.; FUHLER, GWENNY M.. Platelets in aging and cancer-{''}double-edged sword{''}. CANCER AND METASTASIS REVIEWS, v. 39, n. 4, SI, SEP 2020. Web of Science Citations: 0. (17/08119-8, 17/26317-1, 16/14459-3, 15/20412-7, 18/00736-0)
CHAVES NETO, ANTONIO HERNANDES; MACHADO, DAISY; YANO, CLAUDIA LUMY; FERREIRA, CARMEN VERISSIMA. Antioxidant defense and apoptotic effectors in ascorbic acid and beta-glycerophosphate-induced osteoblastic differentiation. DEVELOPMENT GROWTH & DIFFERENTIATION, v. 53, n. 1, p. 88-96, JAN 2011. Web of Science Citations: 3.
MACHADO, DAISY; SHISHIDO, SILVIA M.; QUEIROZ, KARLA C. S.; OLIVEIRA, DIOGO N.; FARIA, ANA L. C.; CATHARINO, RODRIGO R.; SPEK, C. ARNOLD; FERREIRA, CARMEN V.. Irradiated Riboflavin Diminishes the Aggressiveness of Melanoma In Vitro and In Vivo. PLoS One, v. 8, n. 1, JAN 16 2013. Web of Science Citations: 15. (09/00144-7)
FERREIRA-HALDER, CARMEN VERISSIMA; DE SOUSA FARIA, ALESSANDRA VALERIA; ANDRADE, SHEILA SIQUEIRA. Action and function of Faecalibacterium prausnitzii in health and disease. BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY, v. 31, n. 6, p. 643-648, DEC 2017. Web of Science Citations: 21. (15/20412-7, 16/14459-3)
SIPOLI, CAROLINE CASAGRANDE; RADAIC, ALLAN; SANTANA, NATHALIA; DE JESUS, MARCELO BISPO; DE LA TORRE, LUCIMARA GAZIOLA. Chitosan nanoparticles produced with the gradual temperature decrease technique for sustained gene delivery. Biochemical Engineering Journal, v. 103, p. 114-121, NOV 15 2015. Web of Science Citations: 10. (12/01038-9)
FARIA, ALESSANDRA V. S.; ANDRADE, SHEILA S.; REIJM, AGNES N.; SPAANDER, MANON C. W.; DE MAAT, MONIEK P. M.; PEPPELENBOSCH, MAIKEL P.; FERREIRA-HALDER, V, CARMEN; FUHLER, GWENNY M.. Targeting Tyrosine Phosphatases by 3-Bromopyruvate Overcomes Hyperactivation of Platelets from Gastrointestinal Cancer Patients. JOURNAL OF CLINICAL MEDICINE, v. 8, n. 7, JUL 2019. Web of Science Citations: 0. (17/08119-8, 18/00736-0, 15/20412-7)
FARIA, ALESSANDRA V. S.; FONSECA, EMANUELLA MARIA BARRETO; CORDEIRO, HELON GUIMARAES; CLERICI, STEFANO PIATTO; FERREIRA-HALDER, CARMEN VERISSIMA. Low molecular weight protein tyrosine phosphatase as signaling hub of cancer hallmarks. CELLULAR AND MOLECULAR LIFE SCIENCES, v. 78, n. 4, p. 1263-1273, FEB 2021. Web of Science Citations: 0. (17/08119-8, 15/11433-0, 18/03593-6)
(References retrieved automatically from State of São Paulo Research Institutions)
ABRANTES, Julia Laura Fernandes. Expressão ectópica de miR-34a em células de melanoma metastático humano : efeitos sobre vias de sinalização relacionadas com sobrevivência, proliferação e morte celular = Ectopic expression of miR-34a in human metastatic melanoma cells: effects on signaling pathways related to survival, proliferation and cell death. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (09/15374-8)
ROCHA, Karin Juliane Pelizzaro. Modulação da agressividade do câncer de pâncreas, estudo in vitro. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (10/15496-3)
CLERICI, Stefano Piatto. Papel da proteína tirosina fosfatase de baixo peso molecular na biogênese de vesículas extracelulares secretadas pelas células de câncer colorretal. Dissertação (Mestrado) - Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). (16/02770-6)
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LIMIA, Cintia Elisabeth Gomez. Modulação das vias de sinalização de sobrevivência, ciclo celular, resistência e potencial metastático pela etoxzolamida na linhagem celular de adenocarcinoma ductal de pâncreas humano (PANC-1) = : Modulation of survival, cell cycle, resistance signaling pathways and metastatic potential by ethoxzolamide in human pancreatic ductal adenocarcinoma cell line (PANC-1). Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (11/03517-9)
MILANI, Renato. Mapeamento de vias de sinalização envolvidas na resistência a quimioterápicos em células leucêmicas : uma abordagem computacional. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas. (09/18424-6)
ZAMBUZZI, Willian Fernando. Mecanismos de transdução de sinal envolvidos com a diferenciação de osteoblastos e osteocitos. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (04/14906-2)
MACHADO, Daisy. Modulação da agressividade do melanoma por flavinas. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (09/00144-7)
MACHADO, Daisy. Avaliação da citotoxicidade e fototoxicidade da riboflavina : determinação de marcadores moleculares de inflamação, senescencia e morte celular. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (06/05842-6)
LIMA, Sarah Azoubel. Estudo do metabolismo de microRNAs na resistência de células leucêmicas. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (08/07217-7)
ROCHA, Karin Juliane Pelizzaro. Modulação da agressividade do câncer de pâncreas, estudo in vitro. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (10/15496-3)
CLERICI, Stefano Piatto. Papel da proteína tirosina fosfatase de baixo peso molecular na biogênese de vesículas extracelulares secretadas pelas células de câncer colorretal. Dissertação (Mestrado) - Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). (16/02770-6)