Carmen Veríssima Ferreira
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Carmen Veríssima Ferreira in research grants and scholarships supported by FAPESP.
- Low molecular weight protein tyrosine phosphatase in colorectal cancer: from the bench to product generation, AP.TEM
Abstract
Over the past decade, the groups led by Prof. Carmen Veríssima Ferreira and Prof. Maikel Peppelenbosch have explored signal transduction pathways in order to define the action mechanisms of antitumor candidates and for identifyng molecular targets related with the aggressiveness and resistance of tumor cells. In this context, we have investigated cell lines and biopsies of patients with...
- Modulation of kinases and microRNAs by protein tyrosine phosphatase and mechanism of resistance of leukemic cells, AP.R
Abstract
The progress of knowledge about the molecular basis of cancer, has reinforced the concept of this multifactorial disease. The challenge in the coming years is to develop strategies to understand the molecular framework of tumor cells, therapeutic approaches to establish "smart" and personalized therapy in order to increase efficiency, specificity and quality of life of patients. In this...
- Platform based on mist spheroid as a tool for prediction of antitumor potential on colorretal cancer cells, BP.IC
Abstract
Colorectal cancer is still top 3 in the cause of cancer death worldwide. The late diagnosis together with the resistance acquisition of this cancer, are responsible for the low efficiency of the therapeutic protocols available. Thus, more effective therapeutic strategies are desirable. To this end, the molecular knowledge of cancer biology and the use of cellular models with a complexit...
- Tumor-educated platelets and metastasis: relevance of LMWPTP and extracellular vesicles in Colorectal Cancer, BP.DR
Abstract
About 15-20% of colorectal cancer cases progress to metastasis in other organs reducing the efficiency of current therapy regimens and reducing patient survival. In recent years, research groups have focused on the study of the contribution of Extracellular Vesicles (EVs) in the tumor process. EVs are no longer understood as reservoirs for unwanted proteins and have now been considered ...
- Importance of the low molecular weight protein tyrosine phosphatase in the tumoral metabolism reprogramming, BP.PD
Abstract
Tumor cells must assemble cellular components necessary for the synthesis of macromolecules (nucleotides, proteins, lipids) and much energy to double their genome and enlarge their biomass. To that end, tumors alter cellular metabolism to contribute to tumorigenesis and malignancy. The metabolic characteristics and pathways through which tumor cells acquire and replenish their metabolic...
(Only some records are available in English at this moment)
- Role of the low molecular weight protein tyrosine phosphatase in the biogenesis of exosomes secreted by colon rectal cells, BP.MS
Abstract
In 2012 there were more than 14 million new cases of cancer worldwide with approximately 8.2 million deaths. In Brazil, it was estimated for the year 2015, 576 thousand new cases of this disease and from them, 33,000 cases would affect the colon and rectum. This tumor originates from any portion of the colon and rectum, and in 75% of cases it is confined to the colon wall and is curable...
- Irradiated riboflavin in human melanoma: responsiveness of different cell lines and development of pharmaceutical formulation for topical use, BP.MS
Abstract
The incidence of skin cancer is increasing worldwide, and the melanoma is the one with the highest mortality rate, due to its metastatic potential, and worst prognosis. Thus, the search and the development of new effective drugs with antitumor, antiproliferative and antimetastatic properties that improve the therapeutic efficiency, are needed. Our group has been added in the literature ...
- 3-bromopyruvate as molecular tool to uncover the biological basis of protein phosphatase LMWPTP contribution to leukemic cells resistance, BP.PD
Abstract
The great challenge of cancer therapy is to overcome the resistance to chemotherapy and metastasis. Therefore, a better understanding of these processes, the identification of molecular targets, and the development of new drugs with higher efficiency have been aimed of several research groups. In this scenario, our group initiated the investigation on the importance of the low molecular...
(Only some records are available in English at this moment)
- MicroRNAs in stool and platelets biology from gastroenterology cancer patient samples that correlate with ACP1 protein tyrosine phosphatase: colorectal cancer screening, BE.EP.DR
Abstract
The success of cancer prevention and treatment involves efficiency diagnosis and therapy. Over the past years, the Prof. Ferreira-Halder and Prof. Peppelenbosch research groups have investigated cancer cells metabolism to clarify resistance and aggressiveness processes. It was found a correlation between resistance/aggressiveness in leukemia, prostate and colorectal cancer (CRC) and hig...
| 1 / 1 | Ongoing research grants |
| 7 / 1 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 29 / 18 | Completed scholarships in Brazil |
| 3 / 1 | Completed scholarships abroad |
| 44 / 25 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 20 |
| Citations | 279 |
| Cit./Article | 13.9 |
| Data from Web of Science | |
FERREIRA‚ C.V.; JUSTO‚ G.Z.; SOUZA‚ A.; QUEIROZ‚ K.; ZAMBUZZI‚ W.F.; AOYAMA‚ H.; PEPPELENBOSCH‚ M.P.. Natural compounds as a source of protein tyrosine phosphatase inhibitors: Application to the rational design of small-molecule derivatives. Biochimie, v. 88, n. 12, p. 1859-1873, 2006.
CHAVES NETO, ANTONIO HERNANDES; MACHADO, DAISY; YANO, CLAUDIA LUMY; FERREIRA, CARMEN VERISSIMA. Antioxidant defense and apoptotic effectors in ascorbic acid and beta-glycerophosphate-induced osteoblastic differentiation. DEVELOPMENT GROWTH & DIFFERENTIATION, v. 53, n. 1, p. 88-96, JAN 2011. Web of Science Citations: 3.
SIPOLI, CAROLINE CASAGRANDE; RADAIC, ALLAN; SANTANA, NATHALIA; DE JESUS, MARCELO BISPO; DE LA TORRE, LUCIMARA GAZIOLA. Chitosan nanoparticles produced with the gradual temperature decrease technique for sustained gene delivery. Biochemical Engineering Journal, v. 103, p. 114-121, NOV 15 2015. Web of Science Citations: 10. (12/01038-9)
GONCALVES, PAOLA R.; ROCHA-BRITO, KARIN J. P.; FERNANDES, MARUSKA R. N.; ABRANTES, JULIA L.; DURAN, NELSON; FERREIRA-HALDER, CARMEN V.. Violacein induces death of RAS-mutated metastatic melanoma by impairing autophagy process. TUMOR BIOLOGY, v. 37, n. 10, p. 14049-14058, OCT 2016. Web of Science Citations: 4. (13/08896-3)
DE JESUS, MARCELO BISPO; RADAIC, ALLAN; ZUHORN, INGE S.; DE PAULA, ENEIDA. Microemulsion extrusion technique: a new method to produce lipid nanoparticles. JOURNAL OF NANOPARTICLE RESEARCH, v. 15, n. 10, SEP 3 2013. Web of Science Citations: 7. (09/13110-3, 12/01038-9)
MACHADO, DAISY; SHISHIDO, SILVIA M.; QUEIROZ, KARLA C. S.; OLIVEIRA, DIOGO N.; FARIA, ANA L. C.; CATHARINO, RODRIGO R.; SPEK, C. ARNOLD; FERREIRA, CARMEN V.. Irradiated Riboflavin Diminishes the Aggressiveness of Melanoma In Vitro and In Vivo. PLoS One, v. 8, n. 1, JAN 16 2013. Web of Science Citations: 15. (09/00144-7)
FARIA, ALESSANDRA V. S.; ANDRADE, SHEILA S.; REIJM, AGNES N.; SPAANDER, MANON C. W.; DE MAAT, MONIEK P. M.; PEPPELENBOSCH, MAIKEL P.; FERREIRA-HALDER, V, CARMEN; FUHLER, GWENNY M.. Targeting Tyrosine Phosphatases by 3-Bromopyruvate Overcomes Hyperactivation of Platelets from Gastrointestinal Cancer Patients. JOURNAL OF CLINICAL MEDICINE, v. 8, n. 7, JUL 2019. Web of Science Citations: 0. (17/08119-8, 18/00736-0, 15/20412-7)
FERREIRA-HALDER, CARMEN VERISSIMA; DE SOUSA FARIA, ALESSANDRA VALERIA; ANDRADE, SHEILA SIQUEIRA. Action and function of Faecalibacterium prausnitzii in health and disease. BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY, v. 31, n. 6, p. 643-648, DEC 2017. Web of Science Citations: 21. (16/14459-3, 15/20412-7)
CHAVES NETO, ANTONIO HERNANDES; YANO, CLAUDIA LUMY; PAREDES-GAMERO, EDGAR JULIAN; MACHADO, DAISY; JUSTO, GISELLE ZENKER; PEPPELENBOSCH, MAIKEL P.; FERREIRA, CARMEN VERISSIMA. Riboflavin and photoproducts in MC3T3-E1 differentiation. TOXICOLOGY IN VITRO, v. 24, n. 7, p. 1911-1919, OCT 2010. Web of Science Citations: 9.
DE JESUS, MARCELO B.; ZUHORN, INGE S.. Solid lipid nanoparticles as nucleic acid delivery system: Properties and molecular mechanisms. JOURNAL OF CONTROLLED RELEASE, v. 201, p. 1-13, MAR 10 2015. Web of Science Citations: 45. (12/01038-9)
PELIZZARO-ROCHA, KARIN JULIANE; DE JESUS, MARCELO BISPO; RUELA-DE-SOUSA, ROBERTA REGINA; NAKAMURA, CELSO VATARU; REIS, FABIANO SOUZA; DE FATIMA, ANGELO; FERREIRA-HALDER, CARMEN VERISSIMA. Calix[6]arene bypasses human pancreatic cancer aggressiveness: Downregulation of receptor tyrosine kinases and induction of cell death by reticulum stress and autophagy. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v. 1833, n. 12, p. 2856-2865, DEC 2013. Web of Science Citations: 14. (12/01038-9)
TONETO NOVAES, LUIZ FERNANDO; AVILA, CAROLINA MARTINS; PELIZZARO-ROCHA, KARIN JULIANE; VENDRAMINI-COSTA, DEBORA BARBOSA; DIAS, MARINA PEREIRA; BARBOSA TRIVELLA, DANIELA BARRETO; DE CARVALHO, JOAO ERNESTO; FERREIRA-HALDER, CARMEN VERISSIMA; PILLI, RONALDO ALOISE. (-)-Tarchonanthuslactone: Design of New Analogues, Evaluation of their Antiproliferative Activity on Cancer Cell Lines, and Preliminary Mechanistic Studies. CHEMMEDCHEM, v. 10, n. 10, p. 1687-1699, OCT 2015. Web of Science Citations: 5. (10/08673-6, 09/51602-5, 12/09254-2, 10/17544-5, 13/08896-3, 12/24385-6)
BARCELOS, ROSIMEIRE COURA; PELIZZARO-ROCHA, KARIN JULIANE; PASTRE, JULIO CEZAR; DIAS, MARINA PEREIRA; FERREIRA-HALDER, CARMEN VERISSIMA; ALOISE PILLI, RONA IDO. A new goniothalamin N-acylated aza-derivative strongly downregulates mediators of signaling transduction associated with pancreatic cancer aggressiveness. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 87, p. 745-758, NOV 24 2014. Web of Science Citations: 11. (10/16990-1, 10/15496-3, 09/51602-5, 12/24385-6)
CHAVES NETO, ANTONIO HERNANDES; PELIZZARO-ROCHA, KARIN JULIANE; FERNANDES, MARUSKA NEUFERT; FERREIRA-HALDER, CARMEN VERISSIMA. Antitumor activity of irradiated riboflavin on human renal carcinoma cell line 786-O. TUMOR BIOLOGY, v. 36, n. 2, p. 595-604, FEB 2015. Web of Science Citations: 8.
CHAVES NETO, ANTONIO HERNANDES; QUEIROZ, KARLA CRISTIANA; MILANI, RENATO; PAREDES-GAMERO, EDGAR JULIAN; JUSTO, GISELLE ZENKER; PEPPELENBOSCH, MAIKEL P.; FERREIRA, CARMEN VERISSIMA. Profiling the Changes in Signaling Pathways in Ascorbic Acid/beta-Glycerophosphate-Induced Osteoblastic Differentiation. Journal of Cellular Biochemistry, v. 112, n. 1, p. 71-77, JAN 2011. Web of Science Citations: 7.
SOUZA, A. C. S.; AZOUBEL, S.; QUEIROZ, K. C. S.; PEPPELENBOSCH, M. P.; FERREIRA, C. V.. From immune response to cancer: a spot on the low molecular weight protein tyrosine phosphatase. CELLULAR AND MOLECULAR LIFE SCIENCES, v. 66, n. 7, p. 1140-1153, APR 2009. Web of Science Citations: 41.
ZAMBUZZI, WILLIAN F.; YANO, CLAUDIA L.; CAVAGIS, ALEXANDRE D. M.; PEPPELENBOSCH, MAIKEL P.; GRANJEIRO, JOSE MAURO; FERREIRA, CARMEN V.. Ascorbate-induced osteoblast differentiation recruits distinct MMP-inhibitors: RECK and TIMP-2. Molecular and Cellular Biochemistry, v. 322, n. 1-2, p. 143-150, FEB 2009. Web of Science Citations: 29.
ZAMBUZZI, WILLIAN F.; GRANJEIRO, JOSE M.; PARIKH, KAUSHAL; YUVARAJ, SARAVANAN; PEPPELENBOSCH, MAIKEL P.; FERREIRA, CARMEN V.. Modulation of Src Activity by Low Molecular Weight Protein Tyrosine Phosphatase During Osteoblast Differentiation. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 22, n. 5-6, p. 497-506, 2008. Web of Science Citations: 40.
FARIA, ALESSANDRA V. S.; CLERICI, STEFANO P.; DE SOUZA OLIVEIRA, PATRICIA F.; QUEIROZ, KARLA C. S.; PEPPELENBOSCH, MAIKEL P.; FERREIRA-HALDER, CARMEN V.. LMWPTP modulates the antioxidant response and autophagy process in human chronic myeloid leukemia cells. Molecular and Cellular Biochemistry, v. 466, n. 1-2, p. 83-89, MAR 2020. Web of Science Citations: 0. (18/03593-6, 17/08119-8, 15/20412-7)
RADAIC, ALLAN; DE PAULA, ENEIDA; DE JESUS, MARCELO BISPO. Factorial Design and Development of Solid Lipid Nanoparticles (SLN) for Gene Delivery. Journal of Nanoscience and Nanotechnology, v. 15, n. 2, p. 1793-1800, FEB 2015. Web of Science Citations: 10. (09/13110-3, 12/01038-9)
ZAMBUZZI, WILLIAN F.; GRANJEIRO, JOSE M.; PARIKH, KAUSHAL; YUVARAJ, SARAVANAN; PEPPELENBOSCH, MAIKEL P.; FERREIRA, CARMEN V.. Modulation of Src Activity by Low Molecular Weight Protein Tyrosine Phosphatase During Osteoblast Differentiation. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 22, n. 5-6, p. 497-506, 2008. Web of Science Citations: 40.
(References retrieved automatically from State of São Paulo Research Institutions)
NETO, Antonio Hernandes Chaves. Flavinas promovem mudanças na matriz extracelular, vias de transdução de sinal, enzimas antioxidantes e metaloproteinases durante a diferenciação de osteoblastos. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (06/00430-1)
ZAMBUZZI, Willian Fernando. Mecanismos de transdução de sinal envolvidos com a diferenciação de osteoblastos e osteocitos. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (04/14906-2)
MACHADO, Daisy. Avaliação da citotoxicidade e fototoxicidade da riboflavina : determinação de marcadores moleculares de inflamação, senescencia e morte celular. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (06/05842-6)
MACHADO, Daisy. Modulação da agressividade do melanoma por flavinas. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (09/00144-7)
LIMA, Sarah Azoubel. Estudo do metabolismo de microRNAs na resistência de células leucêmicas. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (08/07217-7)
PICARDI, Paty Karoll. Relação entre a atividade da proteína tirosina fosfatase e a ação citotóxica de antimaláricos sobre linfócitos humanos. 72 f. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). Campinas. (00/10542-5)
MILANI, Renato. Mapeamento de vias de sinalização envolvidas na resistência a quimioterápicos em células leucêmicas : uma abordagem computacional. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas. (09/18424-6)
None
LIMIA, Cintia Elisabeth Gomez. Modulação das vias de sinalização de sobrevivência, ciclo celular, resistência e potencial metastático pela etoxzolamida na linhagem celular de adenocarcinoma ductal de pâncreas humano (PANC-1) = : Modulation of survival, cell cycle, resistance signaling pathways and metastatic potential by ethoxzolamide in human pancreatic ductal adenocarcinoma cell line (PANC-1). Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (11/03517-9)
ABRANTES, Julia Laura Fernandes. Expressão ectópica de miR-34a em células de melanoma metastático humano : efeitos sobre vias de sinalização relacionadas com sobrevivência, proliferação e morte celular = Ectopic expression of miR-34a in human metastatic melanoma cells: effects on signaling pathways related to survival, proliferation and cell death. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (09/15374-8)
ABRANTES, Julia Laura Fernandes. Expressão ectópica de miR-34a em células de melanoma metastático humano : efeitos sobre vias de sinalização relacionadas com sobrevivência, proliferação e morte celular = Ectopic expression of miR-34a in human metastatic melanoma cells: effects on signaling pathways related to survival, proliferation and cell death. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (09/15374-8)
CLERICI, Stefano Piatto. Papel da proteína tirosina fosfatase de baixo peso molecular na biogênese de vesículas extracelulares secretadas pelas células de câncer colorretal. Dissertação (Mestrado) - Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). (16/02770-6)