Simone de Fátima Medeiros Sampaio
CV Lattes
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Universidade de São Paulo (USP). Escola de Engenharia de Lorena (EEL) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Engenharia Industrial Química from Faculdade de Engenharia Química de Lorena (2001) and master's at Engenharia Química from Universidade de São Paulo - Escola de Engenharia de Lorena (2006). Has experience in Chemical Engineering, focusing on Chemical Engineering, acting on the following subjects: lcst, rmn 1h, n-vinilcaprolactama, poli(n-vinilcaprolactama) and polymer caracterization. (Source: Lattes Curriculum)
- Evaluation of novel polymer nanoparticles as potential carriers for simultaneous release of a photosensitising agent and an active chemotherapeutic agent, AP.R
Abstract
Since most photosensitizing and chemotherapeutic agents are poorly soluble in water, leading to their rapid elimination from the bloodstream, encapsulation or association of such agents with suitable materials can improve their in vivo solubility and stability. Thus, this project aims to explore polymer nanoparticles, capable of combining photodynamic therapy (PDT) with chemotherapy in ...
- Triggered micelles for enhanced integration of chemotherapy and photodynamic therapy, AP.R
Abstract
The combination of photodynamic therapy (PDT) and chemotherapy is one attractive regime for cancer medication. Nanoparticulate delivery of PDT/chemotherapy payloads involves the highly complex biological, chemical, and transport barriers, among which the rapid cargo release into cytoplasm is one critical step. The generation of traditional triggered-release nanocarriers often necessitat...
- Development of solid formulations and entrapment of poor soluble active ingredients for topical and systemic applications, AP.R
Abstract
The developing of new carrier systems for active ingredients aim to modify the limiting physicochemical properties of drugs, improving thereby its pharmacodynamic (therapeutic effect potentiation), pharmacokinetics (control of the absorption and distribution on tissues) and reducing their toxic effects (local and systemic toxicity). The modification of the permeability and solubility of...
- Development of solid formulations and encapsulation of hydrophobic active principles for topical and systemic application, BP.TT
- Synthesis and characterization of amphiphilic, biodegradable/biocompatible block copolymers for use in drug controlled release systems, BP.IC
Abstract
Taking into account the great interest in the preparation of biocompatible, biodegradable and stimuli-responsive polymeric materials for use in drug controlled release, this research project aims the synthesis of poly(µ-caprolactone)-b-poly(N-vinyl caprolactam) (PCL-b-PNVCL) block copolymers; where a block is biodegradable (PCL) and the other is biocompatible and thermosensitive (PNVCL)...
- Synthesis and characterization of pH and temperature sensitive biocompatibles hydrogels for controlled active principles delivery, BP.IC
Abstract
Several techniques have been studied to reduce the side effects caused by various medical treatments, of which the main ones involve the use of shell materials in order to protect and carry drugs safely up to the desired locations, starting then drug delivery by material degradation or changes in its conformation. Among the most widely used materials for this purpose, biocompatible poly...
(Only some records are available in English at this moment)
- The preparation of thermoresponsive poly(N-vinylcaprolactama) (PNVCL) and poly(e-caprolactone) (pCL)-based nanofibers by electrospinnng for controlled drug delivery systems, BE.EP.IC
Abstract
The Scientific Initiation research project carried out by Graziele Aparecida de Jesus Aguiar, undergraduate student in the Polymer Laboratory of the EEL/USP, under the supervision of Prof. Dr. Simone de Fatima Medeiros and Prof. Dr. Amilton Martins dos Santos, aims the use of biocompatible and thermoresponsive block copolymers in developing systems for controlled drug delivery. The firs...
| 2 / 2 | Ongoing research grants |
| 1 / 1 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 10 / 8 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 15 / 13 | All research grants and scholarships |
| Associated processes | |