Bachelor (2015) and licensed (2017) in Biological Sciences by the Faculty of Philosophy, Sciences, and Letters of Ribeirão Preto - University of São Paulo, where I was a FAPESP fellow for two consecutive years during the four years of Scientific Initiation. Master in Science from the Faculty of Medicine of Ribeirão Preto - University of São Paulo (2017), with a FAPESP grant. Ph.D. in Sciences in the same institution (2022) at the Virology Research Center (CPV), with a FAPESP grant. The Ph.D. was dedicated to understanding the molecular mechanisms associated with the modulation of extracellular vesicle-mediated HIV pathogenesis. Currently, I am a FAPESP postdoctoral fellow at the Blood Center of Ribeirão Preto, developing a research project in cell therapy with NK cells genetically modified using non-viral vectors. (Source: Lattes Curriculum)
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Despite being successful, we need to overcome the limitations of CAR therapy with T cells so that this immunotherapy can treat more patients with reduced cost and increased biosafety. The implementation of this therapy with NK cells brings the possibility of an "Off the shelf" allogeneic therapy, ready and available for treating patients. In addition to NK cells intrinsically eliminating …
Cells actively secrete Extracellular Vesicles (EVs) that may participate in different biological processes in acceptor cells. One of the recently described functions of EVs is their role in modulating pathogenesis of different viruses. Specifically in the case of HIV, it is known that EVs play a dual role in infection. EVs may mediate intercellular communication and activate antiviral res…
Nef is an HIV-1 accessory protein that plays crucial roles in viral pathogenesis. Nef interacts with components of the intracellular protein sorting machinery to create a favorable environment for HIV replication. These interactions lead to modifications in the trafficking itinerary of cell surface proteins involved in immune responses, redirecting them to multivesicular bodies (MVBs), an…
The Human Immunodeficiency Virus Type 1 (HIV-1) causes the progressive debilitation of the immune system in infected individuals, leading to the Acquired Immunodeficiency Syndrome (AIDS), a disease that currently affects over 30 million people in the world. Infection by HIV-1 begins with the fusion of the viral envelope with the host cell plasma membrane that allows entry of the capsid co…
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