Abstract
Bone dynamic depends on interactions between neural, endocrine, paracrine and autocrine components. The activities of osteoblasts, osteoclasts, and osteocytes are modulated by intra and extra-bone factors. Ovarian steroid hormones and adipokines synthesized and released by adipose tissue are important extra-bone factors. The effects of progestins, androgens, estrogens and leptin on bone d…