CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Farmácia Bioquímica from Universidade de São Paulo (1985), graduation at Ciências Farmacêuticas from Universidade de São Paulo (1985), master's at Pharmacology from Universidade Federal de São Paulo (1989) and doctorate at Pharmacology from Universidade Federal de São Paulo (1995). Has experience in Pharmacology, acting on the following subjects: apoptosis, calcio, apoptose, calcium and autofagia. (Source: Lattes Curriculum)
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The present project proposes the installation of a multiomic analysis platform, through the acquisition of an equipment composed of two modules. GeoMx equipment and ncounter have the ability to collect and analyze data from specific regions of fresh or frozen tissue.The GeoMx DSP workflow seamlessly integrates with current histology or genomics workflows to help researchers quickly obtain…
The process of macroautophagia (autophagy) has been the focus of studies on various topics such as neurodegeneration, immune system, inflammation and cancer. In this way, understanding the molecular and cellular mechanisms that modulate autophagy is fundamental. In fact, these studies may help in the identification of important targets for the development of new drugs and therapies. In pr…
The process of macroautophagia (autophagy) has been the focus of studies on various topics such as neurodegeneration, immune system, inflammation and cancer. In this way, understanding the molecular and cellular mechanisms that modulate aautophagy utophagy is fundamental. In fact, these studies may help in the identification of important targets for the development of new drugs and therap…
(Only some records are available in English at this moment)
The project aims to inform about the scientific use ofcannabinoids to advance treatment strategies for Parkinson's Disease. This oneproject is in line with the thematic project entitled "Modulation of autophagy bycannabinoids: neuroprotection in Parkinson's disease." In addition to allowing transparencyresearch promoted by FAPESP, also allows demystifying the use ofcompounds derived from …
Although advances in medicine have been fundamental in increasing life expectancy in recent years, the aging of the population brings with it new challenges. Thus, we have seen a significant increase in the incidence and prevalence of disorders and diseases related to aging, such as neurodegenerative diseases. However, medicine itself, despite the greater ease of diagnosis today, is curre…
(Only some records are available in English at this moment)
The main pathological hallmark of Parkinson's disease (PD) is the presence of aggregates formed by the protein alpha-synuclein called Lewy Bodies. Two point mutations on alpha-synuclein gene (SNCA) lead to the formation of mutated proteins, A30P and A53T, both related to familial Parkinson's disease. According to several evidences, alpha-synuclein binds to mitochondrial complex I, promoti…
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder worldwide. The neurobiological hallmarks of AD consist of extracellular amyloid plaques and intracellular neurofibrillary tangles, which are mainly formed by hyperphosphorylated tau. This hallmark strongly correlates with dementia and is therefore an interesting potential target for small molecules to modulate tau t…
Autophagy is a catabolic process essential for the turnover of cytosolic proteins and organelles. It involves the formation of a double membrane structure known as the autophagosome around a targeted region of the cytosol. The Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca2+ mobilizing messenger that in many cells releases Ca2+ from the endo-lysosomal system, this ef…
| 3 / 3 | Ongoing grants |
| 17 / 10 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 24 / 15 | Completed scholarships in Brazil |
| 4 / 3 | Completed scholarships abroad |
| 50 / 33 | All research grants and scholarships |
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