graduation at Farmácia Bioquímica from Universidade de São Paulo (1985), graduation at Ciências Farmacêuticas from Universidade de São Paulo (1985), master's at Pharmacology from Universidade Federal de São Paulo (1989) and doctorate at Pharmacology from Universidade Federal de São Paulo (1995). Has experience in Pharmacology, acting on the following subjects: apoptosis, calcio, apoptose, calcium and autofagia. (Source: Lattes Curriculum)
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The process of macroautophagia (autophagy) has been the focus of studies on various topics such as neurodegeneration, immune system, inflammation and cancer. In this way, understanding the molecular and cellular mechanisms that modulate autophagy is fundamental. In fact, these studies may help in the identification of important targets for the development of new drugs and therapies. In pr…
The process of macroautophagia (autophagy) has been the focus of studies on various topics such as neurodegeneration, immune system, inflammation and cancer. In this way, understanding the molecular and cellular mechanisms that modulate aautophagy utophagy is fundamental. In fact, these studies may help in the identification of important targets for the development of new drugs and therap…
The process of autophagy culminates at the maturation step in which the nascent autophagosome fuses with the endosomal/lysosomal system to create a degradative compartment, the autolysosome. Functional lysosomes are critical for the maturation of autophagosomes and for the degradation of their content. The inhibition of autophagosome fusion can thus be detected as accumulation of autophag…
(Only some records are available in English at this moment)
Parkinson's Disease (PD) is the second neurodegenerative disorder most common. One of most know neuronal alteration described in PD is the protein aggregation, as consequence of failure in degradation of oxidates and malformed proteins. The cellular process that acts in the degradation of protein aggregates is the autophagy, which have been extensively investigated due its role in the the…
Fibrosis is characterized by an excessive accumulation of extracellular matrix components and is one of the main sequelae acquired after muscle injury. It is most prevalent in severe injuries in which healing occurs slowly and prevents proper muscle contraction - which can lead to muscle contractures and chronic pain. Besides being an important aggravating factor of muscular dystrophies, …
Autophagy is an evolutionarily conserved lysosomal degradation pathway, yet the underlying mechanisms remain poorly understood. In previous studies, we showed the Nicotinic acid adenine dinucleotide phosphate (NAADP) as a potent Ca2+ mobilizing messenger in astrocytes, since NAADP releases Ca2+ from the endo-lysosomal system and this effect was mediated by the two-pore channels (TPCs), es…
The main pathological feature of Parkinson's disease (PD) is the presence of intracitoplasmatic protein aggregates called Lewy Bodies, whose main component is the protein alpha-synuclein on its fibrilar conformation. In the 1990's, two mutations in the gene that encodes alpha-synuclein (SNCA) were described. These mutations lead to transcription of mutant proteins, A30P and A53T, both of …
(Only some records are available in English at this moment)
The main pathological hallmark of Parkinson's disease (PD) is the presence of aggregates formed by the protein alpha-synuclein called Lewy Bodies. Two point mutations on alpha-synuclein gene (SNCA) lead to the formation of mutated proteins, A30P and A53T, both related to familial Parkinson's disease. According to several evidences, alpha-synuclein binds to mitochondrial complex I, promoti…
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder worldwide. The neurobiological hallmarks of AD consist of extracellular amyloid plaques and intracellular neurofibrillary tangles, which are mainly formed by hyperphosphorylated tau. This hallmark strongly correlates with dementia and is therefore an interesting potential target for small molecules to modulate tau t…
Autophagy is a catabolic process essential for the turnover of cytosolic proteins and organelles. It involves the formation of a double membrane structure known as the autophagosome around a targeted region of the cytosol. The Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca2+ mobilizing messenger that in many cells releases Ca2+ from the endo-lysosomal system, this ef…
| 2 / 2 | Ongoing research grants |
| 16 / 9 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 20 / 11 | Completed scholarships in Brazil |
| 4 / 3 | Completed scholarships abroad |
| 43 / 26 | All research grants and scholarships |
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CV Lattes
ORCID