CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas from Universidade de São Paulo (1972), master's at Biochemistry from Universidade de São Paulo (1977) and ph.d. at Biochemistry from Universidade de São Paulo (1979). Has experience in Genetics, focusing on Molecular Genetics and of Microorganisms, acting on the following subjects: trypanosoma cruzi, doença de chagas, parasitologia, antígenos recombinantes and sorodiagnóstico. (Source: Lattes Curriculum)
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Infection by Trypanosoma cruzi, the etiological agent of Chagas Disease remains a major public health problem in Latin America, home of most people infected. In nonendemic regions like/such as the US, Europe, Japan, and Australia there is growing concern about the risks of transmission by blood transfusion (and organ transplant). Considering that T. cruzi taxon comprises genetically disti…
Trypanosoma cruzi is the causative agent of Chagas' disease that affects 15-16 million people in America. Vectorial transmission of T. cruzi still occurs in several regions. Migration from endemic areas to developed countries has led to new cases in the US, Europe, Japan and Australia. Since Triatoma infestans has been controlled and transmission by blood transfusion, halted, oral infecti…
Trypanosoma cruzi, the etiological agent of Chagas' disease, is a highly relevant microorganism from both medical and biological points of view. Although vectorial transmission is mostly under control in the Southern Cone, T cruzi transmission still prevails in Latin America where 15-16 million people are infected. Outbreaks of acute cases of Chagas' disease by oral infection have been re…
Trypanosoma cruzi, the agent of Chagas' disease, is an organism of great interest from the biological point of view. Although the transmission of the disease is controlled in countries of the Southern Cone, T. cruzi continues to be transmitted in many countries in Latin America and infection by this parasite, which affects 15-16 million people, represents a serious public health problem. …
(Only some records are available in English at this moment)
Trypanosoma cruzi is a parasitic protozoan that shows remarkable genetic variability among strains and clones derived from the same strain, with significant differences in the genotypic and phenotypic traits, such as infectivity and pathogenicity patterns, as well as variations in the molecular karyotype. These changes may play an important role in the adaptive response in different hosts…
Genomic analysis indicates that T. cruzi is diploid for most of its chromosomes. However, aneuploidy events were detected in some chromosomes by aCGH and NGS (next generation sequencing). It has been suggested that aneuploidy may be an important factor in generating genetic diversity in T. cruzi, an organism in which sexual reproduction is absent or very rare. By comparing strains and clo…
The induction of DSB (Double Strand Break) on the double strand of DNA by means of ionizing radiation is a useful tool to investigate genetic recombination events in eukaryotes. Mechanisms of repair by DSB contribute to genomic plasticity and may play an important role in chromosomal polymorphism and rearrangements in fungi and protozoa. Our objective is to study the repair of DSB induced…
Trypanosoma cruzi, the etiologic agent of Chagas disease, is a cell highly resistant to ionizing radiation. It can survive doses of gamma irradiation exposure that exceed considerably the absolutely lethal doses for mammalian cells. Lesions more complex and possibly more harmful to the cells are double-stranded breaks in DNA (DSBs), which can be repaired by homologous or nonhomologous rec…
Trypanosoma cruzi is a parasitic protozoan that shows remarkable genetic variability among strains and clones derived from the same strain, with significant differences in the genotypic and phenotypic traits, such as infectivity and pathogenicity patterns, as well as variations in the molecular karyotype. These changes may play an important role in the adaptive response in different hosts…
The gene SAP (Serine-, Alanine-, and Proline-rich protein) encodes polypeptidescontaining a high percentage of serine, alanine and proline residues. With the availability ofthe sequences of T. cruzi Genome Projects, we demonstrated that the SAP proteins areencoded by a multigenic family whose members share a conserved central domain and can begrouped into four subfamilies. Some SAP member…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 13 / 6 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 46 / 18 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 64 / 28 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 28 |
| Citations | 319 |
| Cit./Article | 11.4 |
| Data from Web of Science | |
COSTA, RENATA WATANABE; DA SILVEIRA, JOSE F.; BAHIA, DIANA. Interactions between Trypanosoma cruzi Secreted Proteins and Host Cell Signaling Pathways. FRONTIERS IN MICROBIOLOGY, v. 7, MAR 31 2016. Web of Science Citations: 17. (11/51475-3)
BONFIM-MELO, ALEXIS; FERREIRA, EDEN R.; MORTARA, RENATO A.. Rac1/WAVE2 and Cdc42/N-WASP Participation in Actin-Dependent Host Cell Invasion by Extracellular Amastigotes of Trypanosoma cruzi. FRONTIERS IN MICROBIOLOGY, v. 9, FEB 28 2018. Web of Science Citations: 7. (11/51475-3, 12/21335-8)
FERREIRA, BIANCA LIMA; FERREIRA, EDEN RAMALHO; BONFIM-MELO, ALEXIS; MORTARA, RENATO ARRUDA; BAHIA, DIANA. Trypanosoma cruzi extracellular amastigotes selectively trigger the PI3K/Akt and Erk pathways during HeLa cell invasion. Microbes and Infection, v. 21, n. 10, p. 485-489, DEC 2019. Web of Science Citations: 0. (13/04249-3, 11/51475-3)
FERREIRA, EDEN RAMALHO; HORJALES, EDUARDO; BONFIM-MELO, ALEXIS; CORTEZ, CRISTIAN; DA SILVA, CLAUDIO VIEIRA; DE GROOTE, MICHEL; PASCHOAL SOBREIRA, TIAGO JOSE; CRUZ, MARIO COSTA; LIMA, FABIO MITSUO; CORDERO, ESTEBAN MAURICIO; et al. Unique behavior of Trypanosoma cruzi mevalonate kinase: A conserved glycosomal enzyme involved in host cell invasion and signaling. SCIENTIFIC REPORTS, v. 6, APR 26 2016. Web of Science Citations: 9. (11/51475-3)
STAQUICINI, DANIELA I.; MARTINS, RAFAEL M.; MACEDO, SILENE; SASSO, GISELA R. S.; ATAYDE, VANESSA D.; JULIANO, MARIA A.; YOSHIDA, NOBUKO. Role of GP82 in the Selective Binding to Gastric Mucin during Oral Infection with Trypanosoma cruzi. PLoS Neglected Tropical Diseases, v. 4, n. 3, p. e613, 2010. Web of Science Citations: 27. (06/61450-0)
MAEDA, FERNANDO YUKIO; ALVES, RENAN MELATTO; CORTEZ, CRISTIAN; LIMA, FABIO MITSUO; YOSHIDA, NOBUKO. Characterization of the infective properties of a new genetic group of Trypanosoma cruzi associated with bats. Acta Tropica, v. 120, n. 3, p. 231-237, DEC 2011. Web of Science Citations: 13. (06/61450-0)
MARTINS, NADINI OLIVEIRA; DE SOUZA, RENATA TORRES; CORDERO, ESTEBAN MAURICIO; MALDONADO, DANIELLE CORTEZ; CORTEZ, CRISTIAN; MARINI, MARJORIE MENDES; FERREIRA, EDEN RAMALHO; BAYER-SANTOS, ETHEL; DE ALMEIDA, IGOR CORREIA; YOSHIDA, NOBUKO; et al. Molecular Characterization of a Novel Family of Trypanosoma cruzi Surface Membrane Proteins (TcSMP) Involved in Mammalian Host Cell Invasion. PLoS Neglected Tropical Diseases, v. 9, n. 11, NOV 2015. Web of Science Citations: 11. (11/51475-3)
ANGEL CHIURILLO, MIGUEL; CORTEZ, DANIELLE R.; LIMA, FABIO M.; CORTEZ, CAROLINE; LUIS RAMIREZ, JOSE; MARTINS, ANDRE G.; SERRANO, MYRNA G.; TEIXEIRA, MARTA M. G.; DA SILVEIRA, JOSE FRANCO. The diversity and expansion of the trans-sialidase gene family is a common feature in Trypanosoma cruzi clade members. INFECTION GENETICS AND EVOLUTION, v. 37, p. 266-274, JAN 2016. Web of Science Citations: 5. (11/51475-3)
BAYER-SANTOS, ETHEL; MARINI, MARJORIE M.; DA SILVEIRA, JOSE F.. Non-coding RNAs in Host-Pathogen Interactions: Subversion of Mammalian Cell Functions by Protozoan Parasites. FRONTIERS IN MICROBIOLOGY, v. 8, MAR 21 2017. Web of Science Citations: 9. (11/51475-3, 15/25381-2)
MAEDA, FERNANDO YUKIO; CORTEZ, CRISTIAN; IZIDORO, MARIO AUGUSTO; JULIANO, LUIZ; YOSHIDA, NOBUKO. Fibronectin-Degrading Activity of Trypanosoma cruzi Cysteine Proteinase Plays a Role in Host Cell Invasion. Infection and Immunity, v. 82, n. 12, p. 5166-5174, DEC 2014. Web of Science Citations: 6. (11/51475-3)
CRUZ, MARIO C.; SOUZA-MELO, NORMANDA; DA SILVA, CLAUDIO VIEIRA; DAROCHA, WANDERSON DUARTE; BAHIA, DIANA; ARAUJO, PATRICIA R.; TEIXEIRA, SANTUZA R.; MORTARA, RENATO A.. Trypanosoma cruzi: Role of delta-Amastin on Extracellular Amastigote Cell Invasion and Differentiation. PLoS One, v. 7, n. 12, DEC 18 2012. Web of Science Citations: 19. (11/51475-3, 06/61450-0)
MARTINS, RAFAEL MIYAZAWA; COVARRUBIAS, CHARLES; ROJAS, ROBERT GALVEZ; SILBER, ARIEL MARIANO; YOSHIDA, NOBUKO. Use of L-Proline and ATP Production by Trypanosoma cruzi Metacyclic Forms as Requirements for Host Cell Invasion. Infection and Immunity, v. 77, n. 7, p. 3023-3032, JUL 2009. Web of Science Citations: 46. (06/61450-0)
FERREIRA, BIANCA L.; FERREIRA, EDEN R.; DE BRITO, MARLON V.; SALU, BRUNO R.; OLIVA, MARIA L. V.; MORTARA, RENATO A.; ORIKAZA, CRISTINA M.. BALB/c and C57BL/6 Mice Cytokine Responses to Trypanosoma cruzi Infection Are Independent of Parasite Strain Infectivity. FRONTIERS IN MICROBIOLOGY, v. 9, MAR 26 2018. Web of Science Citations: 5. (11/51475-3, 14/21338-2)
FLORENTINO, PILAR T. V.; REAL, FERNANDO; ORIKAZA, CRISTINA M.; DA CUNHA, JULIA P. C.; VITORINO, FRANCISCA N. L.; CORDERO, ESTEBAN M.; SOBREIRA, TIAGO J. P.; MORTARA, RENATO A.. A Carbohydrate Moiety of Secreted Stage-Specific Glycoprotein 4 Participates in Host Cell Invasion by Trypanosoma cruzi Extracellular Amastigotes. FRONTIERS IN MICROBIOLOGY, v. 9, APR 10 2018. Web of Science Citations: 2. (12/23150-5, 11/51475-3)
BONFIM-MELO, ALEXIS; FERREIRA, EDEN R.; FLORENTINO, PILAR T. V.; MORTARA, RENATO A.. Amastigote Synapse: The Tricks of Trypanosoma cruzi Extracellular Amastigotes. FRONTIERS IN MICROBIOLOGY, v. 9, JUN 27 2018. Web of Science Citations: 3. (11/51475-3, 12/25282-6, 11/03357-1, 12/21335-8)
CORDERO, ESTEBAN M.; CORTEZ, CRISTIAN; YOSHIDA, NOBUKO; DA SILVEIRA, JOSE FRANCO. Signal peptide recognition in Trypanosoma cruzi GP82 adhesin relies on its localization at protein N-terminus. SCIENTIFIC REPORTS, v. 9, MAY 13 2019. Web of Science Citations: 0. (12/14369-3, 11/51475-3)
FERREIRA, EDEN R.; BONFIM-MELO, ALEXIS; CORDERO, ESTEBAN M.; MORTARA, RENATO A.. ERM Proteins Play Distinct Roles in Cell Invasion by Extracellular Amastigotes of Trypanosoma cruzi. FRONTIERS IN MICROBIOLOGY, v. 8, NOV 21 2017. Web of Science Citations: 5. (11/51475-3, 12/25282-6)
CLEMENTE, TATIANA MORDENTE; CORTEZ, CRISTIAN; NOVAES, ANTONIO DA SILVA; YOSHIDA, NOBUKO. Surface Molecules Released by Trypanosoma cruzi Metacyclic Forms Downregulate Host Cell Invasion. PLoS Neglected Tropical Diseases, v. 10, n. 8, AUG 2016. Web of Science Citations: 7. (11/51475-3)
FERREIRA RODRIGUES, JOAO PAULO; TAKAHASHI SANT'ANA, GUILHERME HIDEKI; JULIANO, MARIA APARECIDA; YOSHIDA, NOBUKO. Inhibition of Host Cell Lysosome Spreading by Trypanosoma cruzi Metacyclic Stage-Specific Surface Molecule gp90 Downregulates Parasite Invasion. Infection and Immunity, v. 85, n. 9, SEP 2017. Web of Science Citations: 2. (11/51475-3)
CHIURILLO, MIGUEL A.; MORAES BARROS, ROBERTO R.; SOUZA, RENATA T.; MARINI, MARJORIE M.; ANTONIO, CRISTIANE R.; CORTEZ, DANIELLE R.; CURTO, MARIA A.; LORENZ, HERNAN A.; SCHIJMAN, ALEJANDRO G.; RAMIREZ, JOSE L.; et al. Subtelomeric I-Scel-Mediated Double-Strand Breaks Are Repaired by Homologous Recombination in Trypanosoma cruzi. FRONTIERS IN MICROBIOLOGY, v. 7, DEC 22 2016. Web of Science Citations: 5. (11/51475-3)
CHIURILLO, MIGUEL A.; MORAES BARROS, ROBERTO R.; SOUZA, RENATA T.; MARINI, MARJORIE M.; ANTONIO, CRISTIANE R.; CORTEZ, DANIELLE R.; CURTO, MARIA A.; LORENZ, HERNAN A.; SCHIJMAN, ALEJANDRO G.; RAMIREZ, JOSE L.; et al. Subtelomeric I-Scel-Mediated Double-Strand Breaks Are Repaired by Homologous Recombination in Trypanosoma cruzi. FRONTIERS IN MICROBIOLOGY, v. 7, DEC 22 2016. Web of Science Citations: 5. (11/51475-3)
CORDERO, ESTEBAN M.; CORTEZ, CRISTIAN; YOSHIDA, NOBUKO; DA SILVEIRA, JOSE FRANCO. Signal peptide recognition in Trypanosoma cruzi GP82 adhesin relies on its localization at protein N-terminus. SCIENTIFIC REPORTS, v. 9, MAY 13 2019. Web of Science Citations: 0. (12/14369-3, 11/51475-3)
MARTINS, RAFAEL MIYAZAWA; ALVES, RENAN MELATTO; MACEDO, SILENE; YOSHIDA, NOBUKO. Starvation and rapamycin differentially regulate host cell lysosome exocytosis and invasion by Trypanosoma cruzi metacyclic forms. Cellular Microbiology, v. 13, n. 7, p. 943-954, JUL 2011. Web of Science Citations: 37. (06/61450-0)
CORTEZ, CRISTIAN; YOSHIDA, NOBUKO; BAHIA, DIANA; SOBREIRA, TIAGO J. P.. Structural Basis of the Interaction of a Trypanosoma cruzi Surface Molecule Implicated in Oral Infection with Host Cells and Gastric Mucin. PLoS One, v. 7, n. 7, JUL 31 2012. Web of Science Citations: 20. (06/61450-0)
CORTEZ, CRISTIAN; MARTINS, RAFAEL M.; ALVES, RENAN M.; SILVA, RICHARD C.; BILCHES, LUCIANA C.; MACEDO, SILENE; ATAYDE, VANESSA D.; KAWASHITA, SILVIA Y.; BRIONES, MARCELO R. S.; YOSHIDA, NOBUKO. Differential Infectivity by the Oral Route of Trypanosoma cruzi Lineages Derived from Y Strain. PLoS Neglected Tropical Diseases, v. 6, n. 10, OCT 2012. Web of Science Citations: 14. (06/61450-0)
CRUZ, MARIO C.; SOUZA-MELO, NORMANDA; DA SILVA, CLAUDIO VIEIRA; DAROCHA, WANDERSON DUARTE; BAHIA, DIANA; ARAUJO, PATRICIA R.; TEIXEIRA, SANTUZA R.; MORTARA, RENATO A.. Trypanosoma cruzi: Role of delta-Amastin on Extracellular Amastigote Cell Invasion and Differentiation. PLoS One, v. 7, n. 12, DEC 18 2012. Web of Science Citations: 19. (06/61450-0, 11/51475-3)
FERREIRA, EDEN R.; BONFIM-MELO, ALEXIS; CORDERO, ESTEBAN M.; MORTARA, RENATO A.. ERM Proteins Play Distinct Roles in Cell Invasion by Extracellular Amastigotes of Trypanosoma cruzi. FRONTIERS IN MICROBIOLOGY, v. 8, NOV 21 2017. Web of Science Citations: 5. (12/25282-6, 11/51475-3)
BONFIM-MELO, ALEXIS; FERREIRA, EDEN R.; FLORENTINO, PILAR T. V.; MORTARA, RENATO A.. Amastigote Synapse: The Tricks of Trypanosoma cruzi Extracellular Amastigotes. FRONTIERS IN MICROBIOLOGY, v. 9, JUN 27 2018. Web of Science Citations: 3. (12/25282-6, 11/03357-1, 11/51475-3, 12/21335-8)
(References retrieved automatically from State of São Paulo Research Institutions)
VEAS, Esteban Mauricio Cordero. Estudo do processamento da glicoproteína de superfície de 82kDa(GP82) de tripomastigotas metacíclicas de Trypanosoma cruzi. 83 f. Dissertação (Mestrado) - Escola Paulista de Medicina. Universidade Federal de São Paulo (UNIFESP). São Paulo. (00/09906-2)
BLADES, Carlos Rodrigo Zarate. Imunorreatividade contra antígenos nativos e recombinantes do Trypanosoma cruzi em indivíduos residentes em área endêmica para a doença de Chagas na Bolívia. 121 f. Dissertação (Mestrado) - Escola Paulista de Medicina. Universidade Federal de São Paulo (UNIFESP). São Paulo. (00/02248-0)