bachelor's at Educação Física from Universidade Estadual Paulista Júlio de Mesquita Filho (2003) and master's at Biologia geral e Aplicada from Instituição de biociências de Botucatu (2007). Has experience in Morphology, acting on the following subjects: rato, musculo, composição corporal, lesão and tetania. (Source: Lattes Curriculum)
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Prostate tumors commonly exhibit pronounced accumulations of saturated lipids and cholesterol due to upregulated lipogenesis and intracellular uptake of circulating lipoproteins. Furthermore, lipid deposits fuel the progression of previously benign lesions into increasingly aggressive and metastatic tumors. To mitigate the spread of lethal tumors, the stimulation of cannabinoid receptors …
Evidences suggest that lipid nanoemulsion for the treatment of cancer is an effective treatment alternative for transporting chemotherapeutic drugs to tumor cells. The LDE molecule, which has great versatility and minimal toxicity, is a new perspective to combat some types of neoplasms, including prostate. The reduction of chemotherapy toxicity led us to test the potential of the applicat…
Cancer cachexia is characterized by the involuntary loss of muscle mass during the cancerous state. It is estimated that 30% of deaths during cancer are caused directly by the effects of cachexia. The development of an alternative bionanotechnology for cancer treatment appears to be a promising treatment, allowing the delivery of chemotherapeutic agents in high doses, with low cytotoxicit…
Prostate cancer (CaP) is the leading cause of death in men from cancer. The increase in the activity of proliferative pathways, with a concomitant reduction in apoptotic pathways and loss of tumor suppressors, leads to tumor development and progression. The lipid bioavailability promoted by obesity induced by a high-fat diet (HFD) leads to metabolic reprogramming, providing increased ener…
The candidate has been accepted to conduct BEPE in Madrid, Spain. This research is based on evidence suggesting that lipid nanoemulsion is a promising approach for cancer treatment. The LDE nanoemulsion, due to its remarkable versatility, offers the ability to transport high doses of chemotherapeutics without toxicity, representing a new approach in combating various forms of neoplasms, i…
Evidence suggests that lipid nanoemulsion for cancer treatment is an effective treatment alternative in the delivery of chemotherapeutic agents to tumor cells. The LDE molecule has great versatility to carry drugs with high dosage and present minimal toxicity, being a new perspective for the fight against some types of neoplasms. The reduction of chemotherapy toxicity led us to test the p…
Evidence suggests that lipid nanoemulsion for the treatment of cancer is an effective treatment alternative for transporting chemotherapeutic drugs to tumor cells. The LDE molecule, which has great versatility and minimal toxicity, is a new perspective to combat some types of neoplasms, including prostate. The reduction of chemotherapy toxicity led us to test the potential of the applicat…
The urinary bladder of spontaneously hypertensive rats (SHR) is widely investigated to understand the genetics and pathophysiology of primary hypertension, being characterized as an important etiological factor of lower urinary tract syndrome with bladder dysfunction, increased urinary frequency and reduced urinary capacity. bladder. High-intensity physical exercise (HIIT) is an alternati…
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The low level of physical activity associated with a sedentary modern lifestyle, coupledwith a high-fat diet, can lead to obesity and chronic systemic inflammation, promotingchanges in the immune system which may be related to the development of prostatecancer (PCa). Exercise is recognized for its potential role in reducing the risk of certaincancers, here we hypothesized that aerobic phy…
Cachexia is defined as a multifactorial syndrome characterized by the continuous loss of skeletal muscle mass (with or without loss of adipose tissue) that is not reversed by conventional nutritional support and leads to progressive functional impairment. The principal objective of this internship proposal is complementary to Brazilian research, where we evaluated the effects of cancer ca…
Prostate cancer (PCa) metabolism appears to be unique in comparison with other type of solid cancers. Normal prostate cells mainly rely on glucose oxidation to the synthesis and secretion of citrate. Cancer cells show an altered metabolic phenotype characterized by increased glucose levels, glutaminolysis and synthesis of de novo fatty acid (FA), being considered targets for understanding…
To examine the effect of chronic ischemia associated with vascular disorders on bladder function and the effects of roflumilast treatment, we will investigate morphological and functional changes in the bladder, along with assessments of nitric oxide (NO) and hydrogen sulfide (H2S), and their role in urinary bladder relaxation in rats with internal iliac artery obstruction. Histological t…
| 1 / 1 | Ongoing grants |
| 1 / 1 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 10 / 9 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 19 / 18 | All research grants and scholarships |
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CV Lattes
ORCID