CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Assis. Faculdade de Ciências e Letras (FCL-ASSIS) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduation at fisica from Universidade Estadual Paulista Júlio de Mesquita Filho (2008), master's at Material and Metallurgical Engineering from Universidade Estadual Paulista Júlio de Mesquita Filho (2011) and doctorate at Material and Metallurgical Engineering from Universidade Estadual Paulista Júlio de Mesquita Filho (2014). Has experience in Biotechnology, focusing on Biotechnology, acting on the following subjects: azul de metileno, fosfolipídeos and espectroscopia de impedância. (Source: Lattes Curriculum)
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This one-year SPRINT project is focused in a research area that is emerging rapidly and expanding the limits to resolve cell structures and their functions; stimulated emission depletion (STED) microscopy of living cells tagged to photodynamic therapy. By bridging the groups from Lund University (SE) and UNESP (Brazil) we aim to approach the underlying mechanisms of cell-photosensitizer (…
This research grant has the general objective of continuing the work of the past Fapesp (2016 / 13280-0) research project, as well as to support the research of the graduate students under my supervision. The project is focused on the photosensitization of lipid membranes and underlying mechanisms of the photodynamic efficiency in the treatment of cancer cells. Specifically, Langmuir and …
This project is part of the FAPESP Research Grant - Regular to be developed at the Department of Biological Sciences, Faculty of Science and Letters (FCL) of UNESP, Assis. It aims decentralization of nanobiotechnology research in the state of SP, composing one of the actions that are being taken at the FCL/UNESP to the formation of a nucleus with such characteristics. The goal of this pro…
(Only some records are available in English at this moment)
Photodynamic damage to the cell envelope can inactivate microorganisms and may be used as a tool to combat the phenomenon of super-resistance, empowered by the indiscriminate use of antibiotics. Efficiency in microbial inactivation is dependent on the incorporation of photosensitizers (PS) into the bacterial membranes to trigger oxidation reactions under illumination. Therefore, we shall …
The photodynamic therapy (PDT) is an emerging therapeutic modality, clinically approved and minimally invasive, which has called great attention for the treatment of carcinomas. The method is based on the controlled administration of a photosensitizer (PS), which induces the singlet oxygen (1O2) formation, an oxidizing agent capable of causing necrosis or apoptosis in cancer cells. It is …
The photodynamic inactivation of microorganisms (PDIM) has received considerable attention due to the efficiency against the super-resistance of bacteria. The technique is based on the controlled administration of a photosensitizer (FS), subsequently photoactivated for the generation of reactive oxygen species (ROS), responsible for the inactivation of microorganisms. It is known that the…
Green própolis has received considerable attention due to the multiple applications, including therapeutic properties against the proliferation of tumor cells. Artepillin C is the major component of própolis and its antitumor activity have been the focus of many studies. However, the incorporation effects of Artepillin C into the culture of cancer cells have not yet been explored. Herein,…
Incorporation into cell membranes is key for the action of photosensitizers in photomedicine treatments, with hydroperoxidation as the prominent pathway of lipid oxidation. Herein we shall fabricate Langmuir monolayers of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dipalmitoyl-sn-glycero-3-phosphorylcholine as cellular m…
(Only some records are available in English at this moment)
The photodynamic inactivation of microorganisms (PDIM) has received considerable attention due to the efficiency against the super-resistance of bacteria. The technique is based on the controlled administration of a photosensitizer (PS), subsequently photoactivated for the generation of reactive oxygen species (ROS), responsible for the inactivation of microorganisms. It is known that the…
The photodynamic therapy (PDT) is an emerging therapeutic modality, clinically approved and minimally invasive, which has called great attention for the treatment of carcinomas. The method is based on the controlled administration of a photosensitizer (PS), which induces the singlet oxygen (1O2) formation, an oxidizing agent capable of causing necrosis or apoptosis in cancer cells. It is …
Incorporation into cell membranes is key for the action of photosensitizers in photomedicine treatments, with hydroperoxidation as the prominent pathway of lipid oxidation. Herein we shall fabricate Langmuir monolayers of dioleoylphosphatidylglycerol (DOPG), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and1,2-dipalmitoyl-sn-glycero-3-phospholcholine (DPPC) as cellular membrane models t…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 4 / 4 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 10 / 9 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 23 / 22 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 9 |
| Citations | 53 |
| Cit./Article | 5.9 |
| Data from Web of Science | |
AOKI, P. H. B.; SCHRODER, A. P.; CONSTANTINO, C. J. L.; MARQUES, C. M.. Bioadhesive giant vesicles for monitoring hydroperoxidation in lipid membranes. SOFT MATTER, v. 11, n. 30, p. 5995-5998, 2015. Web of Science Citations: 7. (12/01610-4)
AOKI, P. H. B.; CAETANO, W.; VOLPATI, D.; RIUL, JR., A.; CONSTANTINO, C. J. L.. Sensor Array Made with Nanostructured Films to Detect a Phenothiazine Compound. Journal of Nanoscience and Nanotechnology, v. 8, n. 9, p. 4341-4348, SEP 2008. Web of Science Citations: 22.
PAZIN, WALLANCE MOREIRA; MARQUES RUIZ, GILIA CRISTINE; DOS SANTOS, MARCELO JOSE; BENITES AOKI, PEDRO HENRIQUE; ITO, AMANDO SIUITI; LEOPOLDO CONSTANTINO, CARLOS JOSE. The protective effect of Artepillin C against lipid oxidation on model membranes. JOURNAL OF MOLECULAR LIQUIDS, v. 324, FEB 15 2021. Web of Science Citations: 0. (16/09633-4, 18/22214-6, 18/16713-0)
PEREIRA, LUCAS S. A.; CAMACHO, SABRINA A.; MALFATTI-GASPERINI, ANTONIO A.; JOCHELAVICIUS, KAREN; NOBRE, THATYANE M.; OLIVEIRA, JR., OSVALDO N.; AOKI, PEDRO H. B.. Evidence of photoinduced lipid hydroperoxidation in Langmuir monolayers containing Eosin Y. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 171, p. 682-689, NOV 1 2018. Web of Science Citations: 4. (16/13280-0, 17/13404-3, 13/14262-7)
MOREIRA, LUCAS G.; ALMEIDA JR, ALEXANDRE M.; CAMACHO, SABRINA A.; ESTEVAO, BIANCA M.; OLIVEIRA JR, OSVALDO N.; AOKI, PEDRO H. B.. Chain Cleavage of Bioinspired Bacterial Membranes Photoinduced by Eosin Decyl Ester. Langmuir, v. 36, n. 32, p. 9578-9585, AUG 18 2020. Web of Science Citations: 0. (18/22214-6, 18/14692-5, 13/14262-7, 18/13021-0, 18/16713-0)
BISTAFFA, MARIA J.; KOBAL, MIRELLA B.; SOUZA, PRISCILA S. S.; TOLEDO, KARINA A.; CAMACHO, SABRINA A.; AOKI, PEDRO H. B.. Photo-Induced Necrosis on Oropharyngeal Carcinoma (HEp-2) Cells Mediated by the Xanthene Erythrosine. Journal of Nanoscience and Nanotechnology, v. 20, n. 10, p. 6180-6190, OCT 2020. Web of Science Citations: 0. (13/14262-7, 16/20576-2, 18/14692-5, 18/16713-0)
KOBAL, MIRELLA B.; PAZIN, WALLANCE M.; BISTAFFA, MARIA J.; CONSTANTINO, CARLOS J. L.; TOLEDO, KARINA A.; AOKI, PEDRO H. B.. Correlating Artepillin C cytotoxic activity on HEp-2 cells with bioinspired systems of plasma membranes. Materials Science & Engineering C-Materials for Biological Applications, v. 112, JUL 2020. Web of Science Citations: 0. (18/02392-7, 16/09633-4)
ALMEIDA, JR., ALEXANDRE M.; OLIVEIRA, JR., OSVALDO N.; AOKI, PEDRO H. B.. Role of Toluidine Blue-O Binding Mechanism for Photooxidation in Bioinspired Bacterial Membranes. Langmuir, v. 35, n. 51, p. 16745-16751, DEC 24 2019. Web of Science Citations: 0. (13/14262-7, 18/16713-0)
MOREIRA, LUCAS G.; ALMEIDA JR, ALEXANDRE M.; NIELD, TYLER; CAMACHO, SABRINA A.; AOKI, PEDRO H. B.. Modulating photochemical reactions in Langmuir monolayers of Escherichia coli lipid extract with the binding mechanisms of eosin decyl ester and toluidine blue-O photosensitizers. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 218, MAY 2021. Web of Science Citations: 0. (20/15854-9, 18/16713-0, 18/22214-6, 18/14692-5)
BISTAFFA, MARIA J.; CAMACHO, SABRINA A.; MELO, CARLOS F. O. R.; CATHARINO, RODRIGO R.; TOLEDO, KARINA A.; AOKI, PEDRO H. B.. Plasma membrane permeabilization to explain erythrosine B phototoxicity on in vitro breast cancer cell models. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 223, OCT 2021. Web of Science Citations: 0. (13/14262-7, 16/20576-2, 18/14692-5, 18/16713-0)
(References retrieved automatically from State of São Paulo Research Institutions)
AOKI, Pedro Henrique Benites. Sistemas bioinspirados aplicados no estudo de interação e sensoriamento de derivados xantênicos. 127 f. Tese (Doutorado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências e Tecnologia. (10/17965-0)
AOKI, Pedro Henrique Benites. Filmes nanoestruturados de fosfolipídios como sistemas miméticos de membrana biológica para aplicação em sensores via sers e espectroscopia de impedância. 161 f. Dissertação (Mestrado) - POSMAT - Programa de Pós-Graduação em Ciência e Tecnologia de Materiais. Universidade Estadual Paulista. Presidente Prudente. (08/07241-5)