Abstract
Recent evidence suggests the participation of the lipid mediator "Platelet Activating Factor" (PAF) in tumor growth and resistance to chemo-radiotherapy. PAF acts through a G protein-coupled receptor (PAFR), expressed on tumor cells and also on the tumoral infiltrate cells. It has been shown that irradiation leads to the generation of a series of oxidized phospholipids that act as PAFR ag…