Abstract
This doctoral dissertation is part of the FAPESP thematic project called "Production of extracellular L-asparaginase: from bioprospecting to the Engineering of an antileukemic biopharmaceutical" which main aim is to obtain, in industrial scale, the enzyme L-Asparaginase (ASNase), that is applied to the treatment of Acute Lymphoblastic Leukaemia. Its national production development became …