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Felipe Antunes Calil

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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Felip​e Calil is Bachelor in technological chemistry from the Centro Universitário da Fundação Educacional de Barretos, Brazil (2011). He received his Master in Sciences degree by the University of São Paulo, Brazil in the Chemistry department from the School of Philosophy, Sciences and Linguistic of Ribeirão Preto (FFCLRP), working with immobilized enzymes in capillary to the screening of selective inhibitors (2014). Recently received his Doctor in Sciences Degree by the University of Sao Paulo, School of Pharmaceutical Sciences, working with drug repositioning using antimalarial drugs for selective inhibition of the enzyme dihydroorotate dehydrogenase from Schistosoma mansoni. During both his master and PhD projects, Felipe has worked with enzymes from organisms that cause neglected tropical diseases, such as Leishmaniasis, Schistosomiasis and Chagas' disease. Over the past years, Felipe has been exposed to several biochemical and biophysical techniques including cloning, recombinant expression and protein purification, DLS, ITC, CD, DSF, and especially crystallographic techniques which are being extensively exploited in the structural characterization of the protein targets, as well as for characterizing the binding mechanism of selective inhibitors. (Source: Lattes Curriculum)

Scholarships in Brazil
FAPESP support in numbers * Updated November 09, 2019
Total / Available in English
1 / 1 Completed scholarships in Brazil

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Keywords used by the researcher
Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications5
Citations35
Cit./Article7.0
Data from Web of Science

CALIL, FELIPE A.; DAVID, JULIANA S.; CHIAPPETTA, ESTELA R. C.; FUMAGALLI, FERNANDO; MELLO, RODRIGO B.; LEITE, FRANCO H. A.; CASTILHO, MARCELO S.; EMERY, FLAVIO S.; CRISTINA NONATO, M.. Ligand-based design, synthesis and biochemical evaluation of potent and selective inhibitors of Schistosoma mansoni dihydroorotate dehydrogenase. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 167, p. 357-366, . Web of Science Citations: 0. (15/25099-5, 17/21146-4, 15/06588-5)

CHIBLI, LUCAS A.; SCHMIDT, THOMAS J.; CRISTINA NONATO, M.; CALIL, FELIPE A.; DA COSTA, FERNANDO B.. Natural products as inhibitors of Leishmania major dihydroorotate dehydrogenase. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 157, p. 852-866, . Web of Science Citations: 3. (15/25099-5, 14/26866-7, 14/01443-6, 16/18579-3)

NONATO, M. CRISTINA; DE PADUA, RICARDO A. P.; DAVID, JULIANA S.; REIS, RENATA A. G.; TOMALERI, GIOVANI P.; PEREIRA, HUMBERTO D'MUNIZ; CALIL, FELIPE A.. Structural basis for the design of selective inhibitors for Schistosoma mansoni dihydroorotate dehydrogenase. Biochimie, v. 158, p. 180-190, . Web of Science Citations: 2. (15/25099-5, 11/14269-6)

MAETANI, MICAH; KATO, NOBUTAKA; JABOR, VALQUIRIA A. P.; CALIL, FELIPE A.; NONATO, MARIA CRISTINA; SCHERER, CHRISTINA A.; SCHREIBER, STUART L.. Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P-falciparum Dihydroorotate Dehydrogenase. ACS Medicinal Chemistry Letters, v. 8, n. 4, p. 438-442, . Web of Science Citations: 15. (12/25075-0)

REIS, RENATA A. G.; CALIL, FELIPE ANTUNES; FELICIANO, PATRICIA ROSA; PINHEIRO, MATHEUS PINTO; NONATO, M. CRISTINA. The dihydroorotate dehydrogenases: Past and present. Archives of Biochemistry and Biophysics, v. 632, n. SI, p. 175-191, . Web of Science Citations: 15. (11/23504-9, 07/08703-0, 12/25075-0)

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