- Research Grants
Felip​e Calil is Bachelor in technological chemistry from the Centro Universitário da Fundação Educacional de Barretos, Brazil (2011). He received his Master in Sciences degree by the University of São Paulo, Brazil in the Chemistry department from the School of Philosophy, Sciences and Linguistic of Ribeirão Preto (FFCLRP), working with immobilized enzymes in capillary to the screening of selective inhibitors (2014). Recently received his Doctor in Sciences Degree by the University of Sao Paulo, School of Pharmaceutical Sciences, working with drug repositioning using antimalarial drugs for selective inhibition of the enzyme dihydroorotate dehydrogenase from Schistosoma mansoni. During both his master and PhD projects, Felipe has worked with enzymes from organisms that cause neglected tropical diseases, such as Leishmaniasis, Schistosomiasis and Chagas' disease. Over the past years, Felipe has been exposed to several biochemical and biophysical techniques including cloning, recombinant expression and protein purification, DLS, ITC, CD, DSF, and especially crystallographic techniques which are being extensively exploited in the structural characterization of the protein targets, as well as for characterizing the binding mechanism of selective inhibitors. (Source: Lattes Curriculum)
The repositioning of drugs consists of the evaluation and/or use of existing drugs for treatment of diseases other than those for which they were originally developed. This strategy is of particular interest for the development of new therapeutic strategies, especially for the treatment of neglected diseases, since it allows the evaluation of bioactive potential to molecules which have ...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|