Maria Cristina Volpato

• Abstract

  Local anesthetics (LA) have shown anti-proliferative, cytotoxic, apoptotic, and anti-inflammatory effects. Effects of LA on different cancer cell types have been reported. However, their use is restrict due the intrinsic toxicity on the central nervous system and the short duration. Complexation into cyclodextrins demonstrated improvements in local anesthetics aqueous solubility and other…

  Antitumor effects of plain and 2-hydroxypropyl-²-cyclodextrin lidocaine and articaine formulations on in vitro and in vivo models., AP.R

• Abstract

  Local anesthetics are the most used drugs to control trans and postoperatory pain in medicine and dentistry. Along with their toxicity to cardiovascular and central nervous system they can exert a variety a effects on cells, interfering with healing, inflammation and causing cytotoxicity. Control release systems, such as polymeric nanocarriers have been proposed to reduce drug toxicity an…

  Biocompatibity and permeation studies of articaine-loaded poly(epsilon-caprolactone) nanocapules formulations., BP.DR

• Abstract

  The topical anesthetics avaiable do not allow painless anesthesia, considering pain due to needle insertion and injection. The use of control release systems can improve local anesthetic efficacy. Lidocaine-loaded poly(epsilon-caprolactone) nanocapules has been shown adequate stability, lower citotoxicity and sustained release, becoming a promising formulation for biocompatibility and ane…

  Biocompatibity and permeation studies of lidocaine-loaded poly(epsilon-caprolactone) nanocapsules formulations, BP.DR

• Abstract

  The local anesthetic toxicity has been shown in many cell types and may be associated to the production of proinflammatory cytokines. Articaine has been implicated in many cases of paresthesia after inferior alveolar nerve block; this occurrence seems to be concentration-dependent. The association to carriers (objective of the project "temático" associated), such as liposomes, has been sh…

  Modulatory effects of 2%, 3% and 4% plain articaine and articaine encapsulated into liposomes on citocine production by human gingival fibroblasts., BP.MS

(Only some records are available in English at this moment)