Marcos Roberto Chiaratti
CV Lattes
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Universidade Federal de São Carlos (UFSCAR). Centro de Ciências Biológicas e da Saúde (CCBS) (Institutional affiliation for the last research proposal) Birthplace: Brazil
BS in Animal Science - University of São Paulo, including research training under supervision of Dr. Lawrence C. Smith - Centre de Recherche en Reproduction Animale, University of Montreal, Canada (2005). PhD in Medical Physiopathology - State University of Campinas, under supervision of Dr. Aníbal E. Vercesi and Dr. Flávio V. Meirelles. Research training under supervision of Dr. Joanna Poulton - Department of Obstetrics and Gynaecology, University of Oxford, UK. Post-doctoral researcher in the group of Dr. Flávio V. Meirelles - University of São Paulo. Currently is Assistant Professor - Department of Genetics and Evolution, Federal University of São Carlos. He is interested in the study of female fertility and mitochondrial inheritance in mice, cattle and humans. Towards that, his group undertake experiments based on the use of primordial germ cells (PGCs), oocytes, embryos and stem cells (iPSCs). (Source: Lattes Curriculum)
- Mítochondrial dynamics during oogenesis, AP.R
Abstract
This proposal is based on previous findings of M. Chiaratti's group, which with the expertise provided by the H. Clarke's group seeks to characterize mitochondrial dynamics in oocytes in greater depth, with potential implications to human welfare and health. The proposed scientific activities will investigate three hypotheses in mice: 1) Mfn1 conditional knockout (cKO) inhibits the P13K...
- Mitochondrial dysfunctions and DNA damage in oocytes: implications to fertility, AV.EXT
Abstract
This proposal refers to the visit of Dr. Anand Kumas Pandey to our research group at Laboratory of Genetics and Biotechnology, Department of Genetics and Evolution, Federal University of São Carlos, during a period of 12 months. Dr. Pandey owns a large experience with the study of folliculogenesis and the pharmacologic control of it in mammals. The main goal of his visit is to strength ...
- Effect of the knockout of mitofusins on mouse oocyte: implications to fertility and mitochondrial inheritance, AP.R
Abstract
Mitochondria play a fundamental role during oocyte growth. As a result, the existence of dysfunctional mitochondria or mutant mitochondrial DNA (mtDNA) in oocytes may lead to infertility syndromes and transmission of mitochondrial diseases. Compared to other cell types, oocyte mitochondria distinguish by their increased number, smaller size and rounded shape. These characteristics are d...
- EUROMIT 2017 - Internacional Meeting on Mitochondrial Pathology, AR.EXT
(Only some records are available in English at this moment)
- Does autophagic deficiency increases accumulation of NZB Mitochondrial DNA in the liver?, BP.IC
Abstract
Mitochondrial dynamics regulates several characteristics of mitochondria such as architecture, activity, transport, interaction with other organelles, inheritance and degradation. Important defects in mitochondrial dynamics typical of aging, for example in the autophagic pathway, result in the accumulation of damaged mitochondria and development of pathologies in mice and humans. This i...
- Effect of the mitofusins knockout on the inheritance of deleterious Mitochondrial DNA in mouse embryionic fibroblasts, BP.DR
Abstract
Diseases caused by mutations in the mitochondrial DNA (mtDNA) are among the most common genetic diseases in humans. These diseases result in symptoms that vary in severity between mild and lethal. However, there is no treatment option for treating mitochondrial diseases and their mechanisms of inheritance are unclear. Recently, some works have provided evidence based on in vitro models ...
- Mfn1 knockout in oocytes arrests folliculogenesis in mice through inhibiting the PI3K-Akt pathway, BP.IC
Abstract
Mitochondria are organelles essential to oocyte development, characterized by their round shape, small size and increased amount. These characteristics rely on mitochondrial dynamics, which determine organelle activity, transport and degradation. Mitochondrial dynamics is determined by fusion and fission events. Moreover, fusion of the outer mitochondrial membrane is mediated by mitofus...
- Effect of the knockout of Mitofusin 2 on mitochondria, endoplasmic reticulum and mitophagy in murine oocytes, BP.MS
Abstract
Mitofusins 1 (Mfn1) and 2 (MFN2) are transmembrane GTPases present in the outer mitochondrial membrane and being involved in the regulation of mitochondrial fusion. Since Mfn2 is also present in the membrane of the endoplasmic reticulum (ER), it is also responsible for regulating the morphology and the interaction of ER with the mitochondrion. Thus, there are increasing evidences that M...
- Fertility effect of the knockout of Mitofusin 1 on murine oocytes, BP.MS
Abstract
It is known that mitochondria play a fundamental role when it comes to oocyte fertility. Several studies have associated infertility in women over 40 years old with mitochondrial defects, thus, mitochondria have been an important therapy target in assisted reproduction techniques. However, the molecular mechanisms that drive these mitochondrial defects are unknown. In this context, the ...
(Only some records are available in English at this moment)
- Modelling the mitochondrial bottleneck in vitro, BE.EP.DR
Abstract
Diseases caused by mutations in mitochondrial DNA (mtDNA) affect ~1 in 4,300 people. In addition, almost every person carries very low levels of mutated mtDNA, which may be transmitted down to the maternal lineage and associate with late-onset degenerative diseases. Transmission of mutated mtDNAs in germ cells relies upon the mitochondrial bottleneck, which results in drastic changes in...
- Effects of mitofusin 2 excess during oocyte growth in vitro, BE.EP.IC
Abstract
The determining role of mitochondria in regulating follicular development and oocyte growth is emerging from basic research on model species and clinical studies on female infertility. This new branch of research has been dedicated to deciphering the relationship between oocyte developmental competence and bioenergetics. Mitochondrial activity depends, among other things, on its organel...
- Modelling the human mitochondrial bottleneck in vitro, BE.EP.DR
Abstract
Diseases caused by mutations in mitochondrial DNA (mtDNA) affect ~1 in 4,300 people. In addition, almost every person carries very low levels of mutated mtDNA, which may be transmitted down to the maternal lineage and associate with late-onset degenerative diseases. Inheritance of mutated mtDNAs in germ cells relies upon the mitochondrial bottleneck, which results in drastic changes in ...
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 5 / 5 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 12 / 9 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 25 / 22 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 9 |
| Citations | 126 |
| Cit./Article | 14.0 |
| Data from Web of Science | |
FERREIRA, ROBERTA MACHADO; CHIARATTI, MARCOS ROBERTO; MACABELLI, CAROLINA HABERMANN; RODRIGUES, CARLOS ALBERTO; FERRAZ, MARCIO LEAO; WATANABE, YEDA FUMIE; SMITH, LAWRENCE CHARLES; MEIRELLES, FLAVIO VIEIRA; BARUSELLI, PIETRO SAMPAIO. The Infertility of Repeat-Breeder Cows During Summer Is Associated with Decreased Mitochondrial DNA and Increased Expression of Mitochondrial and Apoptotic Genes in Oocytes. BIOLOGY OF REPRODUCTION, v. 94, n. 3, MAR 1 2016. Web of Science Citations: 17. (10/09561-7, 09/00938-3, 12/07510-1, 11/14207-0, 10/13384-3)
MACABELLI, CAROLINA HABERMANN; FERREIRA, ROBERTA MACHADO; GIMENES, LINDSAY UNNO; TONIZZA DE CARVALHO, NELCIO ANTONIO; SOARES, JULIA GLEYCI; AYRES, HENDERSON; FERRAZ, MARCIO LEAO; WATANABE, YEDA FUMIE; WATANABE, OSNIR YOSHIME; SANGALLI, JULIANO RODRIGUES; et al. Reference Gene Selection for Gene Expression Analysis of Oocytes Collected from Dairy Cattle and Buffaloes during Winter and Summer. PLoS One, v. 9, n. 3, MAR 27 2014. Web of Science Citations: 13. (10/09561-7, 09/00938-3, 12/07510-1, 11/14207-0, 10/13384-3)
MEIRELLES, FLAVIO VIEIRA; BRESSAN, FABIANA FERNANDES; SMITH, LAWRENCE CHARLES; PERECIN, FELIPE; CHIARATTI, MARCOS ROBERTO; STERMAN FERRAZ, JOSE BENTO. Cytoplasmatic inheritance, epigenetics and reprogramming DNA as tools in animal breeding. LIVESTOCK SCIENCE, v. 166, n. SI, p. 199-205, AUG 2014. Web of Science Citations: 3. (10/09561-7, 11/08376-4, 12/50231-6)
MACHADO, THIAGO SIMOES; MACABELLI, CAROLINA HABERMANN; SANGALLI, JULIANO RODRIGUES; RODRIGUES, THIAGO BITTENCOURT; SMITH, LAWRENCE CHARLES; MEIRELLES, FLAVIO VIEIRA; CHIARATTI, MARCOS ROBERTO. Real-Time PCR Quantification of Heteroplasmy in a Mouse Model with Mitochondrial DNA of C57BL/6 and NZB/BINJ Strains. PLoS One, v. 10, n. 8, AUG 14 2015. Web of Science Citations: 5. (10/09561-7, 10/13384-3, 12/50231-6, 12/12951-7)
CHIARATTI, MARCOS R.; BRESSAN, FABIANA F.; FERREIRA, CHRISTINA R.; CAETANO, ALEXANDRE R.; SMITH, LAWRENCE C.; VERCESI, ANIBAL E.; MEIRELLES, FLAVIO V.. Embryo Mitochondrial DNA Depletion Is Reversed During Early Embryogenesis in Cattle. BIOLOGY OF REPRODUCTION, v. 82, n. 1, p. 76-85, JAN 2010. Web of Science Citations: 43.
CHIARATTI, MARCOS ROBERTO; GARCIA, BRUNA MARTINS; CARVALHO, KAREN FREIRE; MACHADO, THIAGO SIMOES; DA SILVA RIBEIRO, FERNANDA KARINA; MACABELLI, CAROLINA HABERMANN. The role of mitochondria in the female germline: Implications to fertility and inheritance of mitochondrial diseases. Cell Biology International, v. 42, n. 6, SI, p. 711-724, JUN 2018. Web of Science Citations: 6. (16/07868-4, 17/05899-2, 12/50231-6, 16/11942-5, 16/11935-9)
CHIARATTI, MARCOS R.; GARCIA, BRUNA M.; CARVALHO, KAREN F.; MACABELLI, CAROLINA H.; DA SILVA RIBEIRO, FERNANDA KARINA; ZANGIROLAMO, AMANDA F.; SARAPIAO, FABIANA D.; SENEDA, MARCELO M.; MEIRELLES, FLAVIO V.; GUIMARAES, FRANCISCO E. G.; et al. Oocyte mitochondria: role on fertility and disease transmission. ANIMAL REPRODUCTION, v. 15, n. 3, p. 231-238, JUL-SEP 2018. Web of Science Citations: 0. (16/07868-4, 17/05899-2, 12/50231-6, 16/11942-5, 16/11935-9)
CHIARATTI, MARCOS ROBERTO; FERREIRA, CHRISTINA RAMIRES; PERECIN, FELIPE; MEO, SIMONE CRISTINA; SANGALLI, JULIANO RODRIGUES; MESQUITA, LIGIA GARCIA; DE CARVALHO BALIEIRO, JULIO CESAR; SMITH, LAWRENCE CHARLES; GARCIA, JOAQUIM MANSANO; MEIRELLES, FLAVIO VIEIRA. Ooplast-mediated developmental rescue of bovine oocytes exposed to ethidium bromide. Reproductive BioMedicine Online, v. 22, n. 2, p. 172-183, Feb. 2011. Web of Science Citations: 23.
CHIARATTI, MARCOS R.; MALIK, SAJIDA; DIOT, ALAN; RAPA, ELIZABETH; MACLEOD, LORNA; MORTEN, KARL; VATISH, MANU; BOYD, RICHARD; POULTON, JOANNA. Is Placental Mitochondrial Function a Regulator that Matches Fetal and Placental Growth to Maternal Nutrient Intake in the Mouse?. PLoS One, v. 10, n. 7, JUL 1 2015. Web of Science Citations: 16.
(References retrieved automatically from State of São Paulo Research Institutions)
CHIARATTI, Marcos Roberto. Estudo do efeito da quantidade de cópias de DNA mitocondrial sobre o desenvolvimento embrionário : implicações na fertilidade e herança mitocondrial. 2010. Tese (Doutorado) – Faculdade de Ciências Médicas. Universidade Estadual de Campinas (UNICAMP).