CV Lattes
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Universidade Federal de São Carlos (UFSCAR). Centro de Ciências Biológicas e da Saúde (CCBS) (Institutional affiliation for the last research proposal) Birthplace: Brazil
BS in Animal Science - University of São Paulo, including research training under supervision of Dr. Lawrence C. Smith - University of Montreal, Canada. PhD in Medical Physiopathology - State University of Campinas, under supervision of Dr. Aníbal E. Vercesi and Dr. Flávio V. Meirelles; research training under supervision of Dr. Joanna Poulton - University of Oxford, UK. Post-doctoral researcher at University of São Paulo. Currently is Associate Professor - Department of Genetics and Evolution, Federal University of São Carlos. He is interested in the study of female fertility and mitochondrial genetics in mice, cattle and humans. Towards that, his group undertake experiments based on the use of genetic modified animals as well as cultured primordial germ cells (PGCs), oocytes, embryos and stem cells. (Source: Lattes Curriculum)
Growing evidence supports that maternal obesity predispose the offspring to cardiometabolic syndromes. In this respect, previous reports have indicated a possible role for mitochondrial and endoplasmic reticulum (ER) dysfunction in oocytes. In parallel, studies involving humans and mice have found that metabolic disease represses mitofusin 2 (MFN2) expression, further impacting mitochondr…
This proposal is based on previous findings of M. Chiaratti's group, which with the expertise provided by the H. Clarke's group seeks to characterize mitochondrial dynamics in oocytes in greater depth, with potential implications to human welfare and health. The proposed scientific activities will investigate three hypotheses in mice: 1) Mfn1 conditional knockout (cKO) inhibits the P13K1A…
This proposal refers to the visit of Dr. Anand Kumas Pandey to our research group at Laboratory of Genetics and Biotechnology, Department of Genetics and Evolution, Federal University of São Carlos, during a period of 12 months. Dr. Pandey owns a large experience with the study of folliculogenesis and the pharmacologic control of it in mammals. The main goal of his visit is to strength ou…
Mitochondria play a fundamental role during oocyte growth. As a result, the existence of dysfunctional mitochondria or mutant mitochondrial DNA (mtDNA) in oocytes may lead to infertility syndromes and transmission of mitochondrial diseases. Compared to other cell types, oocyte mitochondria distinguish by their increased number, smaller size and rounded shape. These characteristics are dep…
(Only some records are available in English at this moment)
Mitochondrial dynamics regulates several characteristics of mitochondria such as architecture, activity, transport, interaction with other organelles, inheritance and degradation. Important defects in mitochondrial dynamics typical of aging, for example in the autophagic pathway, result in the accumulation of damaged mitochondria and development of pathologies in mice and humans. This is …
Mitochondria are organelles essential to oocyte development, characterized by their round shape, small size and increased amount. These characteristics rely on mitochondrial dynamics, which determine organelle activity, transport and degradation. Mitochondrial dynamics is determined by fusion and fission events. Moreover, fusion of the outer mitochondrial membrane is mediated by mitofusin…
Mitofusins 1 (Mfn1) and 2 (MFN2) are transmembrane GTPases present in the outer mitochondrial membrane and being involved in the regulation of mitochondrial fusion. Since Mfn2 is also present in the membrane of the endoplasmic reticulum (ER), it is also responsible for regulating the morphology and the interaction of ER with the mitochondrion. Thus, there are increasing evidences that Mfn…
(Only some records are available in English at this moment)
Diseases caused by mutations in mitochondrial DNA (mtDNA) affect ~1 in 4,300 people. In addition, almost every person carries very low levels of mutated mtDNA, which may be transmitted down to the maternal lineage and associate with late-onset degenerative diseases. Transmission of mutated mtDNAs in germ cells relies upon the mitochondrial bottleneck, which results in drastic changes in t…
The determining role of mitochondria in regulating follicular development and oocyte growth is emerging from basic research on model species and clinical studies on female infertility. This new branch of research has been dedicated to deciphering the relationship between oocyte developmental competence and bioenergetics. Mitochondrial activity depends, among other things, on its organelle…
Diseases caused by mutations in mitochondrial DNA (mtDNA) affect ~1 in 4,300 people. In addition, almost every person carries very low levels of mutated mtDNA, which may be transmitted down to the maternal lineage and associate with late-onset degenerative diseases. Inheritance of mutated mtDNAs in germ cells relies upon the mitochondrial bottleneck, which results in drastic changes in th…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 8 / 6 | Completed research grants |
| 14 / 11 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 28 / 23 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 19 |
| Citations | 223 |
| Cit./Article | 11.7 |
| Data from Web of Science | |
CHIARATTI, MARCOS R.; MACABELLI, CAROLINA H.; AUGUSTO NETO, JOSE DJACI; GREJO, MATEUS PRIOLO; PANDEY, ANAND KUMAR; PERECIN, FELIPE; DEL COLLADO, MAITE. Maternal transmission of mitochondrial diseases. GENETICS AND MOLECULAR BIOLOGY, v. 43, n. 1, 1, 2020. Web of Science Citations: 0. (17/25916-9, 17/19825-0, 16/07868-4, 17/05899-2, 18/13155-6)
FERREIRA, ROBERTA MACHADO; CHIARATTI, MARCOS ROBERTO; MACABELLI, CAROLINA HABERMANN; RODRIGUES, CARLOS ALBERTO; FERRAZ, MARCIO LEAO; WATANABE, YEDA FUMIE; SMITH, LAWRENCE CHARLES; MEIRELLES, FLAVIO VIEIRA; BARUSELLI, PIETRO SAMPAIO. The Infertility of Repeat-Breeder Cows During Summer Is Associated with Decreased Mitochondrial DNA and Increased Expression of Mitochondrial and Apoptotic Genes in Oocytes. BIOLOGY OF REPRODUCTION, v. 94, n. 3, MAR 1 2016. Web of Science Citations: 17. (10/09561-7, 11/14207-0, 12/07510-1, 09/00938-3, 10/13384-3)
MACHADO, THIAGO SIMOES; MACABELLI, CAROLINA HABERMANN; SANGALLI, JULIANO RODRIGUES; RODRIGUES, THIAGO BITTENCOURT; SMITH, LAWRENCE CHARLES; MEIRELLES, FLAVIO VIEIRA; CHIARATTI, MARCOS ROBERTO. Real-Time PCR Quantification of Heteroplasmy in a Mouse Model with Mitochondrial DNA of C57BL/6 and NZB/BINJ Strains. PLoS One, v. 10, n. 8, AUG 14 2015. Web of Science Citations: 5. (10/09561-7, 12/50231-6, 12/12951-7, 10/13384-3)
FERREIRA, CHRISTINA RAMIRES; BURGSTALLER, JOERG PATRICK; PERECIN, FELIPE; GARCIA, JOAQUIM MANSANO; CHIARATTI, MARCOS ROBERTO; MEO, SIMONE CRISTINA; MUELLER, MATHIAS; SMITH, LAWRENCE CHARLES; MEIRELLES, FLAVIO VIEIRA; STEINBORN, RALF. Pronounced Segregation of Donor Mitochondria Introduced by Bovine Ooplasmic Transfer to the Female Germ-Line. BIOLOGY OF REPRODUCTION, v. 82, n. 3, p. 563-571, MAR 2010. Web of Science Citations: 32.
MEIRELLES, FLAVIO VIEIRA; BRESSAN, FABIANA FERNANDES; SMITH, LAWRENCE CHARLES; PERECIN, FELIPE; CHIARATTI, MARCOS ROBERTO; STERMAN FERRAZ, JOSE BENTO. Cytoplasmatic inheritance, epigenetics and reprogramming DNA as tools in animal breeding. LIVESTOCK SCIENCE, v. 166, n. SI, p. 199-205, AUG 2014. Web of Science Citations: 3. (11/08376-4, 10/09561-7, 12/50231-6)
SANGALLI, JULIANO RODRIGUES; CAMARA DE BEM, TIAGO HENRIQUE; PERECIN, FELIPE; CHIARATTI, MARCOS ROBERTO; OLIVEIRA, LILIAN DE JESUS; DE ARAUJO, RENO ROLDI; VALIM PIMENTEL, JOSE RODRIGO; SMITH, LAWRENCE CHARLES; MEIRELLES, FLAVIO VIEIRA. Treatment of Nuclear-Donor Cells or Cloned Zygotes with Chromatin-Modifying Agents Increases Histone Acetylation But Does Not Improve Full-Term Development of Cloned Cattle. CELLULAR REPROGRAMMING, v. 14, n. 3, p. 235-247, JUN 2012. Web of Science Citations: 27. (09/06689-5)
CHIARATTI, MARCOS R.; BRESSAN, FABIANA F.; FERREIRA, CHRISTINA R.; CAETANO, ALEXANDRE R.; SMITH, LAWRENCE C.; VERCESI, ANIBAL E.; MEIRELLES, FLAVIO V.. Embryo Mitochondrial DNA Depletion Is Reversed During Early Embryogenesis in Cattle. BIOLOGY OF REPRODUCTION, v. 82, n. 1, p. 76-85, JAN 2010. Web of Science Citations: 43.
PESSOA, L. V. F.; BRESSAN, F. F.; CHIARATTI, M. R.; PIRES, P. R. L.; PERECIN, F.; SMITH, L. C.; MEIRELLES, F. V.. Mitochondrial DNA dynamics during in vitro culture and pluripotency induction of a bovine Rho0 cell line. Genetics and Molecular Research, v. 14, n. 4, p. 14093-14104, 2015. Web of Science Citations: 4. (11/08376-4, 10/13384-3, 13/08135-2)
MACABELLI, CAROLINA HABERMANN; FERREIRA, ROBERTA MACHADO; GIMENES, LINDSAY UNNO; TONIZZA DE CARVALHO, NELCIO ANTONIO; SOARES, JULIA GLEYCI; AYRES, HENDERSON; FERRAZ, MARCIO LEAO; WATANABE, YEDA FUMIE; WATANABE, OSNIR YOSHIME; SANGALLI, JULIANO RODRIGUES; et al. Reference Gene Selection for Gene Expression Analysis of Oocytes Collected from Dairy Cattle and Buffaloes during Winter and Summer. PLoS One, v. 9, n. 3, MAR 27 2014. Web of Science Citations: 13. (10/09561-7, 11/14207-0, 12/07510-1, 09/00938-3, 10/13384-3)
SANGALLI, JULIANO RODRIGUES; CHIARATTI, MARCOS ROBERTO; CAMARA DE BEM, TIAGO HENRIQUE; DE ARAUJO, RENO ROLDI; BRESSAN, FABIANA FERNANDES; SAMPAIO, RAFAEL VILAR; PERECIN, FELIPE; SMITH, LAWRENCE CHARLES; KING, WILLIAN ALLAN; MEIRELLES, FLAVIO VIEIRA. Development to Term of Cloned Cattle Derived from Donor Cells Treated with Valproic Acid. PLoS One, v. 9, n. 6, JUN 24 2014. Web of Science Citations: 26. (10/19768-8, 10/13384-3, 13/06673-7)
MACHADO, THIAGO S.; MACABELLI, CAROLINA H.; DEL COLLADO, MAITE; MEIRELLES, V, FLAVIO; GUIMARAES, FRANCISCO E. G.; CHIARATTI, MARCOS R.. Evidence of Selection Against Damaged Mitochondria During Early Embryogenesis in the Mouse. FRONTIERS IN GENETICS, v. 11, JUL 15 2020. Web of Science Citations: 0. (12/50231-6, 13/13869-5, 09/54035-4, 12/12951-7, 17/05899-2, 17/04372-0)
GARCIA, BRUNA M.; MACHADO, THIAGO S.; CARVALHO, KAREN F.; NOLASCO, PATRICIA; NOCITI, RICARDO P.; DEL COLLADO, MAITE; CAPO BIANCO, MARIA J. D.; GREJO, MATEUS P.; AUGUSTO NETO, JOSE DJACI; SUGIYAMA, FABRICIA H. C.; et al. Mice born to females with oocyte-specific deletion of mitofusin 2 have increased weight gain and impaired glucose homeostasis. MOLECULAR HUMAN REPRODUCTION, v. 26, n. 12, p. 938-952, DEC 2020. Web of Science Citations: 0. (10/51906-1, 17/05899-2, 17/04372-0, 18/20028-0, 18/06119-3, 16/11935-9, 09/54035-4, 12/50231-6, 16/11942-5)
SAMPAIO, RAFAEL VILAR; SANGALLI, JULIANO RODRIGUES; CAMARA DE BEM, TIAGO HENRIQUE; AMBRIZI, DEWISON RICARDO; DEL COLLADO, MAITE; BRIDI, ALESSANDRA; CAVALCANTE MENDES DE AVILA, ANA CLARA FAQUINELI; MACABELLI, CAROLINA HABERMANN; OLIVEIRA, LILIAN DE JESUS; DA SILVEIRA, JULIANO COELHO; et al. Catalytic inhibition of H3K9me2 writers disturbs epigenetic marks during bovine nuclear reprogramming. SCIENTIFIC REPORTS, v. 10, n. 1, JUL 13 2020. Web of Science Citations: 0. (12/50533-2, 13/07160-3, 15/08807-6, 14/50947-7, 15/25111-5, 14/21034-3, 14/22887-0, 13/08135-2)
CHIARATTI, MARCOS ROBERTO; FERREIRA, CHRISTINA RAMIRES; PERECIN, FELIPE; MEO, SIMONE CRISTINA; SANGALLI, JULIANO RODRIGUES; MESQUITA, LIGIA GARCIA; DE CARVALHO BALIEIRO, JULIO CESAR; SMITH, LAWRENCE CHARLES; GARCIA, JOAQUIM MANSANO; MEIRELLES, FLAVIO VIEIRA. Ooplast-mediated developmental rescue of bovine oocytes exposed to ethidium bromide. Reproductive BioMedicine Online, v. 22, n. 2, p. 172-183, Feb. 2011. Web of Science Citations: 23.
CHIARATTI, MARCOS ROBERTO; FERREIRA, CHRISTINA RAMIRES; MEIRELLES, FLAVIO VIEIRA; MEO, SIMONE CRISTINA; PERECIN, FELIPE; SMITH, LAWRENCE CHARLES; FERRAZ, MARCIO LEAO; DE SA FILHO, MANOEL FRANCISCO; GIMENES, LINDSAY UNNO; BARUSELLI, PIETRO SAMPAIO; et al. Xenooplasmic Transfer between Buffalo and Bovine Enables Development of Homoplasmic Offspring. CELLULAR REPROGRAMMING, v. 12, n. 3, p. 231-236, 2010. Web of Science Citations: 7.
CARVALHO, KAREN F.; MACHADO, THIAGO S.; GARCIA, BRUNA M.; ZANGIROLAMO, AMANDA F.; MACABELLI, CAROLINA H.; SUGIYAMA, FABRICIA H. C.; GREJO, MATEUS P.; NETO, J. DJACI AUGUSTO; TOSTES, KATIANE; RIBEIRO, FERNANDA K. S.; et al. Mitofusin 1 is required for oocyte growth and communication with follicular somatic cells. FASEB JOURNAL, v. 34, n. 6, APR 2020. Web of Science Citations: 1. (09/54035-4, 16/11942-5, 17/04372-0, 12/50231-6, 13/08135-2, 16/11935-9, 16/07868-4)
CHIARATTI, MARCOS R.; GARCIA, BRUNA M.; CARVALHO, KAREN F.; MACABELLI, CAROLINA H.; DA SILVA RIBEIRO, FERNANDA KARINA; ZANGIROLAMO, AMANDA F.; SARAPIAO, FABIANA D.; SENEDA, MARCELO M.; MEIRELLES, FLAVIO V.; GUIMARAES, FRANCISCO E. G.; et al. Oocyte mitochondria: role on fertility and disease transmission. ANIMAL REPRODUCTION, v. 15, n. 3, p. 231-238, JUL-SEP 2018. Web of Science Citations: 0. (16/07868-4, 17/05899-2, 12/50231-6, 16/11942-5, 16/11935-9)
CHIARATTI, MARCOS R.; MALIK, SAJIDA; DIOT, ALAN; RAPA, ELIZABETH; MACLEOD, LORNA; MORTEN, KARL; VATISH, MANU; BOYD, RICHARD; POULTON, JOANNA. Is Placental Mitochondrial Function a Regulator that Matches Fetal and Placental Growth to Maternal Nutrient Intake in the Mouse?. PLoS One, v. 10, n. 7, JUL 1 2015. Web of Science Citations: 16.
CHIARATTI, MARCOS ROBERTO; GARCIA, BRUNA MARTINS; CARVALHO, KAREN FREIRE; MACHADO, THIAGO SIMOES; DA SILVA RIBEIRO, FERNANDA KARINA; MACABELLI, CAROLINA HABERMANN. The role of mitochondria in the female germline: Implications to fertility and inheritance of mitochondrial diseases. Cell Biology International, v. 42, n. 6, SI, p. 711-724, JUN 2018. Web of Science Citations: 6. (16/11942-5, 17/05899-2, 12/50231-6, 16/11935-9, 16/07868-4)
(References retrieved automatically from State of São Paulo Research Institutions)
CHIARATTI, Marcos Roberto. Estudo do efeito da quantidade de cópias de DNA mitocondrial sobre o desenvolvimento embrionário : implicações na fertilidade e herança mitocondrial. Tese (Doutorado) - Faculdade de Ciências Médicas. Universidade Estadual de Campinas (UNICAMP). (06/03516-4)