Abstract
Fbxo7 is one of the 69 human F-box proteins, which interacts with SKP, Cullin and RBX to form the largest family of ubiquitin-ligases known as SCF-type E3 ubiquitin ligases. In addition to the F-box domain of interaction with SKP1, the Fbxl17 contains the LRR domain (Leucine Rich Repeat) which interacts with its substrates. The FBXL17 gene is recurrently disrupted by rearrangements in the…