Leonardo de Oliveira Mendes

• Abstract

  Endocrine disruptors (ED) are exogenous compounds dispersed in the environment and that modify hormonal biosynthesis, implying consequences for human health, including genetic diseases, such as cancer. In the last decade, special attention has been directed to studies involving such compounds, but most researchers do not adequately portray the exposure to which humans are submitted, focus…

  Evaluation of exposure-gene-disease triad: effects of endocrine disrupters mixture human relevant on the prostate microenvironment, AP.R

• Abstract

  Frequent exposure to endocrine disruptors (EDs) has caused an imbalance in the homeostasis of hormone-dependent organs, such as the prostate, triggering histopathological and molecular changes that can culminate in the emergence of chronic diseases, such as cancer. DEs are exogenous compounds found in the environment through the production of various everyday products, including plasticiz…

  MOLECULAR EVALUATION OF PROSTATIC ESTROMAL COLLAGEN FROM RATS EXPOSED FOR A LONG PERIOD TO AN ENVIRONMENTALLY RELEVANT MIXTURE OF ENDOCRINE DISRUPTORS, BP.IC

• Abstract

  Endocrine disruptors (ED) are exogenous compounds dispersed in the environment that modify hormonal biosynthesis, causing several consequences for human health, including chronic diseases, such as cancer. In the last decade, special attention was directed to studies involving such compounds, however, most research does not adequately portray the exposure to which humans are subjected, foc…

  Endocrine disruptors versus hormonal receptors and cell survival: influence of a mixture based on human exposure on the dorsolateral prostate of Sprague-Dawley rats, BP.IC

• Abstract

  Various chemical substances present in the environment are targets of studies due to their direct action on hormone-dependent tissues, such as Bisphenol A (BPA). This substance has one of the largest exposure spectra in the world, as well as being related to the development of tumors. On the other hand, some phytochemicals found in plants, such as Indol-3-Carbinol (I3C) and Genistein (GEN…

  Prostate fractal analysis in rats submitted to hormonal carcinogenesis and exposed to bisphenol A and phytoestrogens, BP.IC

(Only some records are available in English at this moment)

• Abstract

  Excessive alcohol consumption and its consequences arising from their use have reached alarming proportions around the world. One of the effects of ethanol is a decrease of testosterone concentration that alter the androgen-estrogen ratio and may have a direct effect on the prostate gland, hormone-dependent. The estrogen receptor ± and ² are important in prostate homeostasis and its dysre…

  Hormone replacement therapy in the ventral lobe of prostate of UChB rat: effects on estrogen receptors (er alpha e er beta) and the signaling pathway of TGF-beta 1, BE.EP.DR