Abstract
Sibutramine hydrochloride (SIBU) is a selective inhibitor of norepinephrine and serotonin reuptake with anorectic and thermogenic action. The most frequent side effects are dysgeusia and xerostomia. Our studies have shown that SIBU increases the relative and absolute weight and mucin levels of the submandibular glands (SM). The antioxidant defense imbalance may be associated with salivary…