CV Lattes
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Fundação Antonio Prudente (FAP). A C Camargo Cancer Center (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Medicine from the Federal University of Rio de Janeiro - UFRJ (2005). He finished a residency in Internal Medicine at the University of São Paulo - USP, and a residency in Clinical Oncology at the A.C. Camargo Cancer Center. He completed his master's degree in 2013 and his doctorate in 2016, both at the AC Camargo Center. He did his post-doctorate at the Center for DNA Damage and Repair (CDDR) in Professor Alan D'Andrea's laboratory at the Dana-Farber Cancer Institute/Harvard Medical School from 2021 to 2024. He currently works as a doctor in the Clinical Oncology department at AC Camargo Cancer Center focused on gynecology oncology. His main line of research is translational research in gynecological tumors, mainly ovarian tumors studying DNA repair defects and cell cycle regulation. (Source: Lattes Curriculum)
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Ovarian high-grade serous carcinoma (HGSC) is the most frequent histologic type of ovarian cancer. In the past 15 years, the discovery of PARP inhibitors has changed ovarian cancer treatment in different clinical settings.About 20% of HGSC present CCNE1 amplification (amp), a gene that encodes cyclin E1, a central regulator of cell cycle and DNA replication. Despite the relative success o…
Ovarian cancer is the seventh most frequent neoplasm among women in the world and the eighth in mortality. Among ovarian tumors, high-grade serous carcinomas account for 90% of the deaths from the disease, with only 1% of the cases being restricted to the ovary at the time of diagnosis. Overall 5-year survival for patients with stage IIIC is only 25-30% and for patients with stage IV is 1…
Endometrial cancer has an increasing incidence and disease-associated mortality, being the most common gynecological cancer in developed countries. Furthermore, the endometrial immune system is unique: besides acting as a protective barrier against external pathogens, it is modulated by the menstrual cycle and can adopt an immunosuppressive profile, which aids pregnancy development. Howev…
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