Abstract
Shiga toxins (Stx1 and Stx2) produced by Shiga toxin-producing Escherichia coli (STEC) are potent AB5 type cytotoxins. This toxin family is characterized by a structure formed by two characteristic functional domains: the B subunit forms a pentamer responsible to bind to its receptor, GB3; while the A subunit has a catalytic action, whose mechanism is N-glycosidase, removing an adenine fr…