- Research Grants
Eurípedes Constantino Miguel, is Full Professor and Head of the Department of Psychiatry at the Faculdade de Medicina da Universidade de São Paulo (FMUSP, University of São Paulo School of Medicine). He is also an Adjunct Associate Professor at the Yale University School of Medicine Child Study Center and in the Department of Psychiatry and Behavioral Sciences at Duke University. Since 1994, he has been leading research projects in Brazil in the area of obsessive-compulsive disorder (OCD). He was the founder and coordinator of the Obsessive-Compulsive Spectrum Disorders (OCD) Program in his Institution (1994-2009). Since 2003, he has been the Coordinator of the OCD Brazilian Research Consortium across the most important Brazilian universities in the OCD field. The Consortium has collected 1001 OCD cases, phenotypically very well described, and has generated numerous publications. He is a member of the ENIGMA-OCD Working Group, the OCD Brain Imaging Consortium (OBIC), and the International OCD Foundation Genetics Collaborative. He was granted for three times with OCD Program Grant (Projeto Tematico), sponsored by FAPESP (an important Brazilian Research Agency) and recently by NIMH in a global research network grant focused on OCD and related disorders (additional research teams involve collaborators from US-Columbia, India, South Africa and Holland). Since 2009, Dr. Miguel is also Chair of the Child and Adolescent Psychiatry in his Institution. Thus, in the last 9 years, he has started several new lines of research that have culminated with the foundation of the National Institute for Development Psychiatry (www.inpd.org.br), a research organisation focused on developing new methods to identify individuals at risk for mental disorders and testing interventions to prevent or attenuate their expression. Another relevant initiative of this Institute, is the investigation to test the effects of a home visiting intervention for high risk gestations in mitigating the harmful effects of toxic stress over the developing brain during the intra-uterine period and infancy and thus preventing the occurrence of mental disorders. This intervention was also sponsored by the Grand Challenge Canada ? Saving Brains and the Gates Foundation, CNPq, and FAPESP. Between 1997 and 2007 he was one of the editors of the Brazilian Journal of Psychiatry (Revista Brasileira de Psiquiatria). He is also a member of the American College of Neuropsychopharmacology, the Society of Biological Psychiatry, and the Brazilian Psychiatry Association. Prof. Miguel has supervised more than 60 students, from the undergraduate to the postdoctoral level. He has edited 12 books, published over 200 articles, cited more than 9000 times. He currently has an h-index of 51 (Google Scholar citation). Complete List of Published Work at Google Scholar: https://scholar.google.com/citations?hl=en&user=hd03BJ0AAAAJ (Source: Lattes Curriculum)
Obsessive Compulsive Disorder (OCD) is a debilitating syndrome that affects up to 2% of the general population approximately 100,000 Miami-metro residents. Moreover, a recent study in the City of São Paulo revealed that these estimates could be up to 6.7% in urban areas. Despite growing research, much regarding risk for OCD remains unknown. This application aims to facilitated collabora...
The proposed visiting researcher grant will support research activities of Dr. Elizabeth Shephard from the Institute of Psychiatry, Psychology, & Neuroscience, King's College London, to be conducted at the Department of Psychiatry, University of São Paulo with the host Professor Euripedes Constantino Miguel. Dr. Shephard has expertise in using cognitive neuroscience techniques to study ...
The obsessive-compulsive disorder (OCD) is the fourth most common psychiatric disorder and is related to significant disability, poor quality of life and disrupted family functioning. Despite the existence of effective therapeutic interventions for OCD (e.g. serotonin reuptake inhibitors and behavior psychotherapy), up to half of OCD patients do not respond satisfactorily with treatment...
(Only some records are available in English at this moment)
Studies of proton magnetic resonance spectroscopy (¹H MRS) indicate that obsessive-compulsive disorder (OCD) patients, when compared to healthy individuals, may present dysfunctional glutamatergic and GABAergic systems (the two main neurotransmitters in the central nervous system, that plays excitatory and inhibitory roles, respectively) in prefrontal and striatal brain regions. However...
The main objectives of this project are to better understand the pathophysiology of obsessive- compulsive disorder (OCD) using new experimental models to identify predictive factors of response to conventional as well as new treatment alternatives. Instead of investigating OCD from a phenotypic perspective, in this project we will adopt well established behavioral paradigms related to f...
The main objective of this project is to investigate the involvement of genome de novo and inherited rare variations in a sample of patients with Obsessive-compulsive disorder (OCD) (n=80) and their family members (n=80 families) using whole exome sequencing. Based on the observation that genes associated with similar diseases are likely to interact with each other heavily in a network,...
(Only some records are available in English at this moment)
Obsessive-compulsive disorder (OCD) is a prevalent neurodevelopmental disorder in the general population, ranked among the 10 most debilitating disorders of any kind, in terms of lost earnings and diminished quality of life. OCD is a familial condition, with first-degree relatives of OCD probands being ~4-5 times more likely to have OCD themselves, compared to relatives of unaffected co...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|
(References retrieved automatically from State of São Paulo Research Institutions)
SÁ, Daniel Graça Fatori de. Custo econômico e social do transtorno obsessivo-compulsivo e outros transtornos mentais na infância. 2016. Tese (Doutorado) – Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (12/09246-0)
HOUNIE, Ana Gabriela. Transtornos do espectro obsessivo-compulsivo e febre reumática: um estudo de transmissão familiar. 2003. Tese (Doutorado) – Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (98/15013-9)
SHAVITT, Roseli Gedanke. Fatores preditivos de resposta ao tratamento em pacientes com transtorno obsessivo-compulsivo. 2002. Tese (Doutorado) – Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (99/01548-0)
MERCADANTE, Marcos Tomanik. Transtorno obsessivo-compulsivo, tiques, síndrome de Tourette e outros transtornos psiquiátricos em pacientes com febre reumática, com ou sem Coréia de Sydenham.. 1999. Tese (Doutorado) – Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (95/05013-3)
MATHIS, Maria Alice Simões de. Características fenotípicas do transtorno obsessivo-compulsivo com idade de início precoce dos sintomas. 2007. Dissertação (Mestrado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (04/11462-6)
CHACON, Priscila. Dimensões de sintomas obsessivo-compulsivos em pares de irmãos concordantes para o diagnóstico de Transtorno Obsessivo-Compulsivo (TOC). 2008. Dissertação (Mestrado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (01/06697-6)
SILVA, Cristina Belotto da. Estudo comparativo de efetividade da terapia cognitivo-comportamental em grupo e dos inibidores seletivos de recaptação da serotonina em pacientes com transtorno obsessivo-compulsivo: um ensaio clínico pragmático. 2009. Tese (Doutorado) – Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (06/50829-8)
DINIZ, Juliana Belo. Estratégia de potencialização medicamentosa no transtorno obsessivo-compulsivo resistente: um estudo duplo-cego controlado. 2011. Tese (Doutorado) – Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (06/50273-0)
MATHIS, Maria Alice Simões de. Trajetória das comorbidades no transtorno obsessivo-compulsivo. 2012. Tese (Doutorado) – Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (08/57598-7)
CAPPI, Carolina. Variações raras no genoma de pacientes com transtorno obsessivo-compulsivo. 2013. Tese (Doutorado) – Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (08/11537-7)