Abstract
Sickle cell anemia results from a point mutation in the beta globin gene. This mutation leads to the substitution of glutamic acid to a valine at the sixth position of the polypeptide chain. This disease is charactereized by the homozygosity of the hemoglobin S (HbSS). The level of HbF present in the erythrocytes of patients with hemolytic anemia may decrease the number of clinical compli…