Abstract
The aim of this project is to describe the application plan of the School of Pharmaceutical Sciences for the grant related to the "Reserva Técnica Institucional" of Fapesp. (AU)
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Ricardo Luiz Nunes de Souza
CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Faculdade de Ciências Farmacêuticas (FCFAR) (Institutional affiliation for the last research proposal) Birthplace: Brazil
PhD in Psychobiology (University of São Paulo). He has expertise in Behavioral Pharmacology at Institute of Pharmacology, University of Zurich, Switzerland (1989) and University of Leeds, UK (1999). Full Professor of Pharmacology at School of Pharmaceutical Sciences, São Paulo Sate University (UNESP). Head of the Joint Graduate Program in Physiological Sciences (UFSCar-UNESP, 2013-2017). Member of the editorial board of the Acta Neurobiologiae Experimentalis. Nunes-de-Souza was also President of the Brazilian Society for Neurosciences and Behavior (2014-2017). Since 2018 is head of the scientific committee of the III FALAN Congress (Federation of Latin American and Caribbean Neuroscience Societies). Dr. Nunes-de-Souza was chosen by the CNPq Deliberative Council (CD) to form the Advisory Committee on Biophysics, Biochemistry, Pharmacology, Physiology and Neurosciences (CA-BF), with a three-year term of office from 01/07/2019 to 30/06/2022. Principal line of research: Neurobiology of pain and defense reactions in rodents. (Source: Lattes Curriculum)
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Research grants
- Neurobiological substrates of the medial prefrontal cortex functional lateralization on defensive reactions induced by social defeat stress in mice, AP.R
Abstract
Stress situations are risk factors for the development of mental disorders. However, not everyone exposed to a stressor develops such disorders, probably because each subject displays distinct degrees of susceptibility or resilience phenotypes to stress. The search for the neural systems underlying these phenotypes has highlighted the medial prefrontal cortex (mPFC) and, more recently, it…
- Hierarchic defensive system in mice: role of the corticotrophin-releasing factor (CRF), AP.R
Abstract
Threatening situations elicit defense responses such as fight/flight and freezing behaviors, autonomic activation and antinociception. These reactions are orchestrated by limbic structures of the brain defensive system [e.g., medial prefrontal cortex (mPFC), hypothalamus (Hyp), amygdala (Amy) and periaqueductal gray matter (PAG)]. Recent results have shown that intra-PAG injections of cor…
- 22nd Annual Meeting of the International Behavioral Neuroscience Society, AR.EXT
(Only some records are available in English at this moment)
Scholarships in Brazil
- Evaluation of the medial prefrontal cortex interhemispheric connections in the resilience and susceptibility to the social defeat stress: because the side matters, BP.PD
Abstract
Although the known association between stress and the development of psychiatric diseases, not every individual who has experienced adversities develops such diseases. This is related to individual characteristics, which determine how each individual cope and adapts to adversity, leading up to its resilience or susceptibility to the stress. The great prevalence of such diseases, together …
- Functional lateralization of the medial prefrontal cortex in anxiety and depression in mice: molecular and psychopharmacological evaluations, BP.DR
Abstract
Stress, which can be defined as a condition that disturbs the physiological and psychological balance of an individual, is a risk factor for the development of neuropsychiatric diseases. However, not all individuals who experience a stressful event develop illnesses related to it. This is due to the existence of differences in the ability to adapt to stress, that is, the manifestation of …
- Role of the amygdala in fear-induced antinociception: behavioral, pharmacological and immunohistochemical assessments, BP.DR
Abstract
Exposure of animals to the open elevated plus maze (oEPM : 4 open arms) elicits intense antinociceptive response, but the mechanisms , neurotransmitters and substrates are still poorly understood . In this sense, the amygdaloid complex stands out as one of the main brain regions involved in processing aversive stimuli and emotional responses related to fear, being appointed in many studie…
(Only some records are available in English at this moment)
Scholarships abroad
- Evaluating the consequences of psychosocial stress exposure to the functional lateralization of the media prefrontal cortex: a morphological and functional approach, BE.EP.PD
Abstract
Recently, the importance of the functional lateralization of the medial prefrontal cortex (mPFC) in modulating the emotional responses to aversive stimuli has been gaining attention. Results involving the manipulation of the mPFC activity, specifically the prelimbic (PrL) mPFC, suggest that the chronic stress exposure induce long term changes in this region, decreasing the left mPFC (LmPF…
- Effects of corticotrophin releasing factor (CRF) overexpression and Crf1 and CRF2 receptors knockout within limbic structures on defensive behavior in mice: influence of acute and chronic stress, BE.EP.PD
Abstract
Corticotrophin releasing factor (CRF) is an important coordinator of neuroendocrine, autonomic, behavioral and immunological responses to stressful stimuli. CRF is able to modulate several behaviors, such as defensive reactions, and its malfunction in humans is associated with psychiatry disorders related to stress, including anxiety and affective disorders. Most of the CRF behavioral eff…
Total / Available in English
| 1 / 1 | Ongoing research grants |
| 7 / 4 | Completed research grants |
| 25 / 12 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 2 / 1 | Completed scholarships abroad |
| 36 / 19 | All research grants and scholarships |
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