Abstract
Vitiligo is a hypopigmentary disease and its pathogenesis has not been completely elucidated. Several intrinsic and extrinsic factors are related to its occurrence, and among these factors, oxidative stress has been shown to affect melanin metabolism and impair melanocyte survival, furthermore can induce an autoimmune response in T cells. Piperine, a Piper alkaloid nigrum L. has been show…