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Universidade Estadual de Campinas (UNICAMP). Centro de Biologia Molecular e Engenharia Genética (CBMEG) (Institutional affiliation from the last research proposal) Birthplace: Estados Unidos
Daniel Groban Olson in research grants and scholarships supported by FAPESP.
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In this project, the formation of an Advanced Second Generation (A2G) Biofuels lab based at the University of Campinas is proposed. The mission of the A2G lab is to develop and enable deployment of disruptive 2G technology for sustainable production of bioethanol from sugar cane and energy cane at much lower cost than today's technology. The central focus of the A2G lab is a new paradigm …
This postdoctoral project focuses on improving genetic tools for Clostridium thermocellum, a bacterium renowned for its superior lignocellulose degradation capabilities compared to commercial cellulase preparations. The goal is to merge this native deconstruction ability with ethanol production at commercially viable levels, necessitating the development of enhanced genetic tools, a profo…
In this project, the formation of an Advanced Second Generation (A2G) Biofuels lab based at the University of Campinas is proposed. The mission of the A2G lab is to develop and enable deployment of disruptive 2G technology for sustainable production of bioethanol from sugar cane and energy cane at much lower cost than today's technology. The central focus of the A2G lab is a new paradigm …
Several lines of evidence suggesting that conversion of pyruvate to acetyl-CoA limits ethanol titer. In many thermophilic bacteria, including C. thermocellum, this conversion is mediated by the pyruvate ferredoxin oxidoreductase (PFOR) enzyme. To identify metabolic bottlenecks in enzymes from C. thermocellum, we replaced the T. saccharolyticum enzymes with C. thermocellum enzymes. Of the…
(Only some records are available in English at this moment)
The lignocellulose-deconstruction capability of C. thermocellum has been shown to be decisively better than commercial cellulase preparations (Lynd et al., 2022). Combining this native deconstruction capability with ethanol production at commercially viable titers and yields requires development of genetic tools for thesenon-model microbes, better understanding of metabolic features of bo…
It is proposed the formation of an Advanced Second Generation Biofuels (A2G) laboratory based at the State University of Campinas. The mission of the A2G laboratory is to develop and enable the deployment of disruptive 2G technology for the sustainable production of bioethanol from sugarcane and energy cane at a much lower cost than current technology. The consolidated bioprocess for the …
Clostridium thermocellum is a thermophilic candidate for consolidated bioprocessing by carrying out both cellulose solubilization and fermentation. However, despite significant efforts, the maximum ethanol titer achieved to date remains below industrially required targets (90% of theoretical yield and 40 g/L titer). In microorganisms, fermentation of pyruvate to ethanol can proceed either…
Inducible promoter systems are pivotal for precise control of gene expression, facilitating various biotechnological applications. However, the functionality of existing systems at high temperatures (>50°C) remains limited, posing challenges for thermophilic industrial processes. This project aims to address this gap by developing thermophilic inducible promoters with high dynamic range a…
Second-generation ethanol production from lignocellulose will help meet today's energy, environmental and climate challenges. To carry out lignocellulosic biomass fermentation, several research groups are studying the usage of the bacterium Clostridium thermocellum, one of the best cellulose solubilizers among all known microorganisms. However, for this process to be economically viable, …
Second generation (2G) biofuels are produced from non-food feedstocks, such as agricultural wastes. These fuels are highly valued nowadays as a low-carbon alternative to fossil fuels. Consolidated bioprocessing (CBP) is a leading strategy for low-cost conversion of lignocellulosic biomass into fuels, where biomass solubilization and sugar fermentation are combined in one step. Clostridium…
| 1 / 1 | Ongoing grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 3 / 3 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 12 / 12 | All research grants and scholarships |
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