Patrick Daniel Varga-Weisz

• Abstract

  Inflammatory bowel disease, such as Crohn's disease (CD, affecting the entire digestive track) and ulcerative colitis (UC, affecting the colon) are dramatically on the rise, especially in the developing world, including Brazil. It is thought that changes in lifestyle, including hygiene and nutrition (such as a change from a vegetable rich diet to a diet rich in fat, meat and carbohydrates…

  Multi-user Equipment approved in grant 19/16113-5: Chromium Controller & Next GEM Accessory Kit, AP.EMU

• Abstract

  Inflammatory bowel disease, such as Crohn's disease (CD, affecting the entire digestive track) and ulcerative colitis (UC, affecting the colon) are dramatically on the rise, especially in the developing world, including Brazil. It is thought that changes in life style, including hygiene and nutrition (such as a change from a vegetable rich diet to a diet rich in fat, meat and carbohydrate…

  Chromatin dynamics in host-microbiome crosstalk in health and disease, AP.SPEC

• Abstract

  Changes in the packaging of the genomic material, chromatin remodelling processes, play critical roles in gene regulation, including during inflammation. However, how these changes are established and their role during ulcerative colitis, are not well understood. Furthermore, the temporal, cell type specific progression of colitis requires illumination. Here we will use a mouse model for …

  Chromatin remodelling in Colitis in intestinal epithelial cells, BP.PD

• Abstract

  The human colon provides an ecosystem for a huge number and diversity of microbes, mostly bacteria. These are normally commensal or beneficial, as they play an important role in the digestion of food matter and contribute to the generation of bioactive molecules, such as vitamins and short chain fatty acids. They also have important functions in the defense against pathogens and immunity.…

  Identification of histone crotonylation specific chromatin remodeling mechanisms in intestinal cells, BP.PD

• Abstract

  Protein Posttranslational Modifications (PTMs) link to metabolic states through their dependence on precursor molecules such as ATP or acetyl-CoA. This is also true for PTMs of histones which are an important facet of gene regulation. The newly discovered range of histone acylations, such as crotonylation, adds a new layer of complexity to this molecular process. The nexus between histone…

  Role of histone acylations in linking gene expression to cellular metabolism in the gut, BP.DD

(Only some records are available in English at this moment)