Abstract
TP53 (p53) is a tumor suppressor whose functions and mutations are widely studied. TP53 germinative mutations can lead to Li-Fraumeni syndrome (LFS), which is characterized by the development of tumors in multiple organs at an early age. The R337H substitution (TP53R337H) in the oligomerization domain impairs the formation of tetramers, necessary for the correct function of TP53. The few …