Marisa Passarelli
CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina (FM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
PhD at Physiology from Universidade de São Paulo (1998). Postdoctoral feloowship at Metabolism,Endocrinology and Nutrition, University of Washington, Seattle, USA. Co-responsible for the Lipids Laboratory (LIM 10), University of Sao Paulo Medical School. Professor of Universidade Nove de Julho (UNINOVE). Experience in Lipid Metabolism - Lipoprotein Metabolism in Diabetes and Exercise (Source: Lattes Curriculum)
- Unraveling mechanisms of glycemic control and chronic complications of Diabetes mellitus: contributions to human health, AP.TEM
Abstract
Diabetes Mellitus (DM) and its chronic complications are the greatest public health problem. It is a must to develop approaches that help to control glycemia and to reduce the incidence of complications. Target territories to develop complications, which will be focused on in this proposal, include kidney, cardiovascular system, brain (Alzheimer's Disease also referred to as DM3) and li...
- Influency of the glycemic control and nefropathy stage on the reverse cholesterol transport in Diabetes mellitus: role of metabolic memory induced by advanced glycated albumin, AP.R
Abstract
Advanced glycation end products are prevalent in hyperglycemia but also in detoxification failure of glycation intermediate compounds that intensify the carbonyl stress in diabetic kidney disease. Advanced glycated albumin (AGE-alb) independently associates with cardiovascular risk in diabetes mellitus (DM) and in chronic kidney disease. In macrophages, AGE-alb increases oxidative stres...
- Advanced glycation end products and renin-angiotensin system: impact on the development of atherosclerosis in dyslipidemic mice, AP.R
Abstract
Advanced glycation end products (AGE) are independently associated with the development of atherosclerosis. AGE diminish macrophage cholesterol efflux and increase the uptake of LDL favoring intracellular cholesterol accumulation. Besides, AGE induce the expression of angiotensinogen and AT-1 receptor in macrophages sharing with the angiotensin II receptors intracellular pathways that l...
- New players in glycemic control and chronic complications of Diabetes mellitus: preventive and therapeutic perspectives, AP.TEM
Abstract
Diabetes mellitus is a growing public health problem. In order to combat this disease, it is necessary to have deep knowledge of its pathophysiological mechanisms. The present project attempts to investigate features related to the development/progression of DM, seeking to expand preventive and therapeutic approaches for the control of glycemia and the development of chronic complicatio...
(Only some records are available in English at this moment)
- Advanced glycation products, endoplasmic reticulum stress and the modulation of the reverse cholesterol transport in human arteries with different levels Atherosclerotic lesion, BP.PD
Abstract
Advanced Glycation End products (AGE) are independently related to cardiovascular risk. AGE damage lipid homeostasis in the arterial wall by reducing the amount of HDL receptor, ABCA-1, that mediates the excess cholesterol exportation by the reverse cholesterol transport. Mechanistic studies show that this occurs by the induction of oxidative and endoplasmic reticulum stress and inflamm...
- HDL proteomics and functionality in diabetes mellitus chronic kidney disease: association with advanced glycation end products, BP.MS
Abstract
Advanced glycation products (AGEs) are prevalent in chronic kidney disease regardless of the presence of hyperglycemia. They are formed due to the failure to detoxify dicarbonyl compounds, precursors of AGEs, because of the gradual loss of renal function and oxidative stress. AGEs alter lipid and lipoprotein metabolism and are independently associated with cardiovascular risk. In additi...
- Effect of aerobic exercise training in plasma and arterial distribution and concentration of oxysterols in dyslipidemic mice, BP.MS
Abstract
Oxysterols are cholesterol oxidation derivatives that regulate the development of atherosclerosis by the selective modulation of oxidative stress and inflammation and by mediating arterial wall macrophage lipid exportation. Besides, oxysterols are bile acid precursors in the final step of cholesterol excretion into bile. 27 hydroxycholesterol is the most abundant oxysterol in circulatio...
- Anti-inflammatory role of apolipoprotein A-IV in diabetes mellitus and its impact on macrophage reverse cholesterol transport: influence of advanced glycation, BP.PD
Abstract
The inverse association between HDL and coronary heart disease is well established by epidemiological studies although recent clinical trials and genetic studies have failed in demonstrating cardiovascular benefits by increasing plasma HDL-cholesterol levels. This may be related to the great heterogeneity of HDL particle in size and composition and to the partial loss of function of th...
(Only some records are available in English at this moment)
- Involvement of the RAGE/AGE axis in macrophage lipid accumulation induced by human advanced glycated albumin, BE.EP.PD
Abstract
Advanced glycation end products (AGE) are elevated in diabetes mellitus (DM) and predict the development of atherosclerosis. AGE-albumin induces oxidative stress that is linked to the reduction in ABCA-1 levels and macrophage cholesterol accumulation. We analyzed if the effect of AGE-albumin in disturbing macrophage reverse cholesterol transport (RCT) can be prevented by silencing or kn...
- Anti-inflammatory function of apolipoprotein A-IV in diabetes mellitus and its effects on reverse cholesterol transport from macrophages: influence of modification by advanced glycation, BE.EP.PD
Abstract
The inverse association between HDL and coronary heart disease is well established by epidemiological studies although recent clinical trials and genetic studies have failed in demonstrating cardiovascular benefits by increasing plasma HDL-cholesterol levels. This may be related to the great heterogeneity of HDL particle in size and composition and to the partial loss of function of th...
- Intracellular trafficking of HDL receptor - ABCA-1 - in macrophages treated with advanced glycated albumin: influence of glycemic control in reverse cholesterol transport, BE.EP.PD
Abstract
In diabetes mellitus (DM), alterations in lipid and lipoprotein metabolism contribute to the elevated risk of atherosclerotic disease. Hyperglycemia is an important contributor for micro and macrovascular disease in DM, leading to the generation of reactive oxygen species (ROS) and the formation of reactive oxoaldehydes, such as glyoxal, methylglyoxal and glycolaldehyde that mediate the...
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 13 / 7 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 26 / 9 | Completed scholarships in Brazil |
| 5 / 4 | Completed scholarships abroad |
| 46 / 22 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 18 |
| Citations | 178 |
| Cit./Article | 9.9 |
| Data from Web of Science | |
ROCCO, D. D. F. M.; OKUDA, L. S.; PINTO, R. S.; FERREIRA, F. D.; KUBO, S. K.; NAKANDAKARE, E. R.; QUINTAO, E. C. R.; CATANOZI, S.; PASSARELLI, M.. Aerobic Exercise Improves Reverse Cholesterol Transport in Cholesteryl Ester Transfer Protein Transgenic Mice. LIPIDS, v. 46, n. 7, p. 617-625, JUL 2011. Web of Science Citations: 15.
IBORRA, RODRIGO T.; MACHADO-LIMA, ADRIANA; CASTILHO, GABRIELA; NUNES, VALERIA S.; ABDALLA, DULCINEIA S. P.; NAKANDAKARE, EDNA R.; PASSARELLI, MARISA. Advanced Glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. LIPIDS IN HEALTH AND DISEASE, v. 10, SEP 29 2011. Web of Science Citations: 15. (09/53869-9, 07/59710-6)
MACHADO-LIMA, ADRIANA; IBORRA, RODRIGO T.; PINTO, RAPHAEL S.; CASTILHO, GABRIELA; SARTORI, CAMILA H.; OLIVEIRA, ERIKA R.; OKUDA, LIGIA S.; NAKANDAKARE, EDNA R.; GIANNELLA-NETO, DANIEL; MACHADO, UBIRATAN F.; et al. In Type 2 Diabetes Mellitus Glycated Albumin Alters Macrophage Gene Expression Impairing ABCA1-Mediated Cholesterol Efflux. Journal of Cellular Physiology, v. 230, n. 6, p. 1250-1257, JUN 2015. Web of Science Citations: 10. (07/59710-6, 09/53869-9)
MACHADO, JULIANA T.; IBORRA, RODRIGO T.; FUSCO, FERNANDA B.; CASTILHO, GABRIELA; PINTO, RAPHAEL S.; MACHADO-LIMA, ADRIANA; NAKANDAKARE, EDNA R.; SEGURO, ANTONIO C.; SHIMIZU, MARIA H.; CATANOZI, SERGIO; et al. N-acetylcysteine prevents endoplasmic reticulum stress elicited in macrophages by serum albumin drawn from chronic kidney disease rats and selectively affects lipid transporters, ABCA-1 and ABCG-1. ATHEROSCLEROSIS, v. 237, n. 1, p. 343-352, NOV 2014. Web of Science Citations: 11. (07/59710-6)
ROCCO‚ D.D.F.M.; OKUDA‚ LS; PINTO‚ RS; FERREIRA‚ FD; KUBO‚ SK; NAKANDAKARE‚ ER; QUINTÃO‚ E.C.R.; CATANOZI‚ S.; PASSARELLI‚ M.. Aerobic exercise improves reverse cholesterol transport in cholesteryl ester transfer protein transgenic mice. LIPIDS, p. 1-9, 2011.
GOMES, DIEGO JUVENAL; VELOSA, ANA PAULA; OKUDA, LIGIA SHIMABUKURO; FUSCO, FERNANDA BUENO; DA SILVA, KAROLINNE SANTANA; PINTO, PAULA RAMOS; NAKANDAKARE, EDNA REGINA; CORREA-GIANNELLA, MARIA LUCIA; WOODS, TOM; BRIMBLE, MARGARET ANNE; et al. Glycated albumin induces lipid infiltration in mice aorta independently of DM and RAS local modulation by inducing lipid peroxidation and inflammation. JOURNAL OF DIABETES AND ITS COMPLICATIONS, v. 30, n. 8, p. 1614-1621, NOV-DEC 2016. Web of Science Citations: 3. (11/16164-7, 12/19755-9, 13/11084-0, 11/04631-0, 13/23392-1, 13/02854-7)
THIEME, KARINA; DA SILVA, KAROLLINE S.; FABRE, NELLY T.; CATANOZI, SERGIO; MONTEIRO, MARIA BEATRIZ; SANTOS-BEZERRA, DANIELE PEREIRA; COSTA-PESSOA, JULIANA MARTINS; OLIVEIRA-SOUZA, MARIA; MACHADO, UBIRATAN F.; PASSARELLI, MARISA; et al. N-Acetyl Cysteine Attenuated the Deleterious Effects of Advanced Glycation End-Products on the Kidney of Non-Diabetic Rats. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 40, n. 3-4, p. 608-620, 2016. Web of Science Citations: 3. (13/00713-7, 14/17251-9, 12/04831-1, 12/18724-2)
DA SILVA, KAROLLINE S.; PINTO, PAULA R.; FABRE, NELLY T.; GOMES, DIEGO J.; THIEME, KARINA; OKUDA, LIGIA S.; IBORRA, RODRIGO T.; FREITAS, VANESSA G.; SHIMIZU, MARIA H. M.; TEODORO, WALCY R.; et al. N-acetylcysteine Counteracts Adipose Tissue Macrophage Infiltration and Insulin Resistance Elicited by Advanced Glycated Albumin in Healthy Rats. FRONTIERS IN PHYSIOLOGY, v. 8, SEP 22 2017. Web of Science Citations: 5. (12/04831-1, 12/18724-2, 14/17251-9, 11/15153-1, 16/15603-0, 12/12088-7, 13/02854-7)
PINTO, PAULA R.; DA SILVA, KAROLLINE S.; IBORRA, RODRIGO T.; OKUDA, LIGIA S.; GOMES-KJERULF, DIEGO; FERREIRA, GUILHERME S.; MACHADO-LIMA, ADRIANA; ROCCO, DEBORA D. F. M.; NAKANDAKARE, EDNA R.; MACHADO, UBIRATAN F.; et al. Exercise Training Favorably Modulates Gene and Protein Expression That Regulate Arterial Cholesterol Content in CETP Transgenic Mice. FRONTIERS IN PHYSIOLOGY, v. 9, MAY 8 2018. Web of Science Citations: 3. (14/07617-6, 12/18724-2, 13/11084-0, 12/12088-7, 11/15153-1, 16/15603-0, 12/19112-0, 15/21072-5, 13/02854-7)
PINTO-JUNIOR, DANILO C.; SILVA, KAROLLINE S.; MICHALANI, MARIA L.; YONAMINE, CAIO Y.; ESTEVES, JOAO V.; FABRE, NELLY T.; THIEME, KARINA; CATANOZI, SERGIO; OKAMOTO, MARISTELA M.; SERAPHIM, PATRICIA M.; et al. Advanced glycation end products-induced insulin resistance involves repression of skeletal muscle GLUT4 expression. SCIENTIFIC REPORTS, v. 8, MAY 25 2018. Web of Science Citations: 3. (12/20432-0, 12/18724-2, 14/17251-9, 13/00713-7, 16/15603-0, 16/25155-5)
IBORRA, RODRIGO T.; MACHADO-LIMA, ADRIANA; CASTILHO, GABRIELA; NUNES, VALERIA S.; ABDALLA, DULCINEIA S. P.; NAKANDAKARE, EDNA R.; PASSARELLI, MARISA. Advanced Glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. LIPIDS IN HEALTH AND DISEASE, v. 10, SEP 29 2011. Web of Science Citations: 15. (09/53869-9, 07/59710-6)
ROCCO‚ D.D.F.M.; OKUDA‚ LS; PINTO‚ RS; FERREIRA‚ FD; KUBO‚ SK; NAKANDAKARE‚ ER; QUINTÃO‚ E.C.R.; CATANOZI‚ S.; PASSARELLI‚ M.. Aerobic exercise improves reverse cholesterol transport in cholesteryl ester transfer protein transgenic mice. LIPIDS, p. 1-9, 2011.
MACHADO-LIMA, ADRIANA; IBORRA, RODRIGO T.; PINTO, RAPHAEL S.; CASTILHO, GABRIELA; SARTORI, CAMILA H.; OLIVEIRA, ERIKA R.; OKUDA, LIGIA S.; NAKANDAKARE, EDNA R.; GIANNELLA-NETO, DANIEL; MACHADO, UBIRATAN F.; et al. In Type 2 Diabetes Mellitus Glycated Albumin Alters Macrophage Gene Expression Impairing ABCA1-Mediated Cholesterol Efflux. Journal of Cellular Physiology, v. 230, n. 6, p. 1250-1257, JUN 2015. Web of Science Citations: 10. (07/59710-6, 09/53869-9)
MACHADO, JULIANA T.; IBORRA, RODRIGO T.; FUSCO, FERNANDA B.; CASTILHO, GABRIELA; PINTO, RAPHAEL S.; MACHADO-LIMA, ADRIANA; NAKANDAKARE, EDNA R.; SEGURO, ANTONIO C.; SHIMIZU, MARIA H.; CATANOZI, SERGIO; et al. N-acetylcysteine prevents endoplasmic reticulum stress elicited in macrophages by serum albumin drawn from chronic kidney disease rats and selectively affects lipid transporters, ABCA-1 and ABCG-1. ATHEROSCLEROSIS, v. 237, n. 1, p. 343-352, NOV 2014. Web of Science Citations: 11. (07/59710-6)
GOMES, DIEGO JUVENAL; VELOSA, ANA PAULA; OKUDA, LIGIA SHIMABUKURO; FUSCO, FERNANDA BUENO; DA SILVA, KAROLINNE SANTANA; PINTO, PAULA RAMOS; NAKANDAKARE, EDNA REGINA; CORREA-GIANNELLA, MARIA LUCIA; WOODS, TOM; BRIMBLE, MARGARET ANNE; et al. Glycated albumin induces lipid infiltration in mice aorta independently of DM and RAS local modulation by inducing lipid peroxidation and inflammation. JOURNAL OF DIABETES AND ITS COMPLICATIONS, v. 30, n. 8, p. 1614-1621, NOV-DEC 2016. Web of Science Citations: 3. (11/16164-7, 12/19755-9, 13/11084-0, 11/04631-0, 13/23392-1, 13/02854-7)
DA SILVA, KAROLLINE S.; PINTO, PAULA R.; FABRE, NELLY T.; GOMES, DIEGO J.; THIEME, KARINA; OKUDA, LIGIA S.; IBORRA, RODRIGO T.; FREITAS, VANESSA G.; SHIMIZU, MARIA H. M.; TEODORO, WALCY R.; et al. N-acetylcysteine Counteracts Adipose Tissue Macrophage Infiltration and Insulin Resistance Elicited by Advanced Glycated Albumin in Healthy Rats. FRONTIERS IN PHYSIOLOGY, v. 8, SEP 22 2017. Web of Science Citations: 5. (12/04831-1, 12/18724-2, 14/17251-9, 11/15153-1, 16/15603-0, 12/12088-7, 13/02854-7)
THIEME, KARINA; DA SILVA, KAROLLINE S.; FABRE, NELLY T.; CATANOZI, SERGIO; MONTEIRO, MARIA BEATRIZ; SANTOS-BEZERRA, DANIELE PEREIRA; COSTA-PESSOA, JULIANA MARTINS; OLIVEIRA-SOUZA, MARIA; MACHADO, UBIRATAN F.; PASSARELLI, MARISA; et al. N-Acetyl Cysteine Attenuated the Deleterious Effects of Advanced Glycation End-Products on the Kidney of Non-Diabetic Rats. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 40, n. 3-4, p. 608-620, 2016. Web of Science Citations: 3. (13/00713-7, 14/17251-9, 12/04831-1, 12/18724-2)
PINTO, PAULA R.; DA SILVA, KAROLLINE S.; IBORRA, RODRIGO T.; OKUDA, LIGIA S.; GOMES-KJERULF, DIEGO; FERREIRA, GUILHERME S.; MACHADO-LIMA, ADRIANA; ROCCO, DEBORA D. F. M.; NAKANDAKARE, EDNA R.; MACHADO, UBIRATAN F.; et al. Exercise Training Favorably Modulates Gene and Protein Expression That Regulate Arterial Cholesterol Content in CETP Transgenic Mice. FRONTIERS IN PHYSIOLOGY, v. 9, MAY 8 2018. Web of Science Citations: 3. (14/07617-6, 12/18724-2, 13/11084-0, 12/12088-7, 11/15153-1, 16/15603-0, 12/19112-0, 15/21072-5, 13/02854-7)
PINTO-JUNIOR, DANILO C.; SILVA, KAROLLINE S.; MICHALANI, MARIA L.; YONAMINE, CAIO Y.; ESTEVES, JOAO V.; FABRE, NELLY T.; THIEME, KARINA; CATANOZI, SERGIO; OKAMOTO, MARISTELA M.; SERAPHIM, PATRICIA M.; et al. Advanced glycation end products-induced insulin resistance involves repression of skeletal muscle GLUT4 expression. SCIENTIFIC REPORTS, v. 8, MAY 25 2018. Web of Science Citations: 3. (12/20432-0, 12/18724-2, 14/17251-9, 13/00713-7, 16/15603-0, 16/25155-5)
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Karolline Santana da. Albumina modificada por glicação avançada e resistência insulínica em ratos: foco no tecido adiposo periepididimal e nas ações da N-acetilcisteína. 2017. Tese (Doutorado) – Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo.
PINTO, Paula Ramos. Treinamento físico aeróbio em camundongos selvagens e transgênicos para CETP não altera a remoção de colesterol celular e a expressão de genes envolvidos no fluxo de lípides em macrófagos e arco aórtico. 2015. Dissertação (Mestrado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo.
LIMA, Adriana Machado Saldiba de. Albumina modificada por glicação avançada no diabete melito tipo 1 e 2 prejudica o transporte reverso de colesterol e favorece o acúmulo de lípides em macrófagos. 2011. Tese (Doutorado) – Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo.
PINTO, Raphael de Souza. Inibição do estresse oxidativo em macrófagos previne a redução no conteúdo do receptor ABCA-1 induzida por albumina modificada por glicação avançada. 2011. Tese (Doutorado) – Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo.
CASTILHO, Gabriela. Inibição do estresse do retículo endoplasmático restaura o conteúdo de ABCA-1 e o efluxo de colesterol em macrófagos tratados com albumina modificada por glicação avançada. 2012. Tese (Doutorado) – Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo.
IBORRA, Rodrigo Tallada. Treinamento físico aeróbio aumenta a capacidade antioxidante das HDL e reduz o estresse oxidativo plasmático no diabete melito tipo 2. 2006. Dissertação (Mestrado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo.
MACHADO, Juliana Tironi. N-acetilcisteína reduz o estresse de retículo endoplasmático e afeta seletivamente o efluxo de colesterol de macrófagos mediado por ABCA-1 e ABCG-1 na doença renal crônica. 2014. Dissertação (Mestrado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo.
FERREIRA, Guilherme da Silva. Treinamento físico aeróbio altera seletivamente a concentração e o metabolismo arterial de óxidos de colesterol e reduz colesterol na aorta de camundongos dislipidêmicos. 2017. Dissertação (Mestrado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo.
OKUDA, Ligia Shimabukuro. Albumina modificada por glicação avançada sensibiliza macrófagos à inflamação prejudicando o transporte reverso de colesterol e a atividade anti-inflamatória da HDL. 2012. Tese (Doutorado) – Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo.