CV Lattes
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ORCID
Universidade de São Paulo (USP). Faculdade de Medicina (FM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
PhD at Physiology from Universidade de São Paulo (1998). Postdoctoral feloowship at Metabolism,Endocrinology and Nutrition, University of Washington, Seattle, USA. Co-responsible for the Lipids Laboratory (LIM 10), University of Sao Paulo Medical School. Professor of Universidade Nove de Julho (UNINOVE). Experience in Lipid Metabolism - Lipoprotein Metabolism in Diabetes and Exercise (Source: Lattes Curriculum)
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The etiopathogenesis of breast cancer is diverse and the molecular classification of tumors and the calculation of recurrence score are used as basis for prognosis and therapeutic choice. High density lipoproteins (HDL) are inversely associated with tumor genesis by modulating the lipid content required for tumor replication, adhesion and migration, and performing antioxidant and anti-inf…
Diabetes Mellitus (DM) and its chronic complications are the greatest public health problem. It is a must to develop approaches that help to control glycemia and to reduce the incidence of complications. Target territories to develop complications, which will be focused on in this proposal, include kidney, cardiovascular system, brain (Alzheimer's Disease also referred to as DM3) and live…
Advanced glycation end products are prevalent in hyperglycemia but also in detoxification failure of glycation intermediate compounds that intensify the carbonyl stress in diabetic kidney disease. Advanced glycated albumin (AGE-alb) independently associates with cardiovascular risk in diabetes mellitus (DM) and in chronic kidney disease. In macrophages, AGE-alb increases oxidative stress …
Advanced glycation end products (AGE) are independently associated with the development of atherosclerosis. AGE diminish macrophage cholesterol efflux and increase the uptake of LDL favoring intracellular cholesterol accumulation. Besides, AGE induce the expression of angiotensinogen and AT-1 receptor in macrophages sharing with the angiotensin II receptors intracellular pathways that lea…
Diabetes mellitus is a growing public health problem. In order to combat this disease, it is necessary to have deep knowledge of its pathophysiological mechanisms. The present project attempts to investigate features related to the development/progression of DM, seeking to expand preventive and therapeutic approaches for the control of glycemia and the development of chronic complications…
(Only some records are available in English at this moment)
Cardiovascular disease (CVD) is the leading cause of mortality in individuals with chronic kidney disease (CKD). The gradual loss of renal function is influenced and also affects traditional risk factors for CVD; however, the control of blood pressure and dyslipidemia is not able to prevent cardiovascular morbidity and mortality. This is attributed to the action of non-classical risk fact…
Advanced glycation products (AGE) are important contributors to metabolic memory by mediating cellular modifications during the decompensation metabolic period, which are sustained after adequate metabolic control in diabetes mellitus (DM). We have recently demonstrated a persistent effect of albumin modified by advanced glycation (albumin-AGE) on impaired cholesterol removal from macroph…
The etiopathogenesis of breast cancer is diverse and the molecular classification of tumors and the calculation of the recurrence score are used as a basis for prognosis and therapeutic choice. High- density lipoproteins (HDL) are inversely associated with tumor genesis, as they modulate the lipid content, necessary for tumor replication, adhesion and migration, and perform antioxidant an…
Advanced Glycation End products (AGE) are independently related to cardiovascular risk. AGE damage lipid homeostasis in the arterial wall by reducing the amount of HDL receptor, ABCA-1, that mediates the excess cholesterol exportation by the reverse cholesterol transport. Mechanistic studies show that this occurs by the induction of oxidative and endoplasmic reticulum stress and inflammat…
Advanced glycation products (AGEs) are prevalent in chronic kidney disease regardless of the presence of hyperglycemia. They are formed due to the failure to detoxify dicarbonyl compounds, precursors of AGEs, because of the gradual loss of renal function and oxidative stress. AGEs alter lipid and lipoprotein metabolism and are independently associated with cardiovascular risk. In addition…
Oxysterols are cholesterol oxidation derivatives that regulate the development of atherosclerosis by the selective modulation of oxidative stress and inflammation and by mediating arterial wall macrophage lipid exportation. Besides, oxysterols are bile acid precursors in the final step of cholesterol excretion into bile. 27 hydroxycholesterol is the most abundant oxysterol in circulation …
(Only some records are available in English at this moment)
Advanced glycation end products (AGE) are elevated in diabetes mellitus (DM) and predict the development of atherosclerosis. AGE-albumin induces oxidative stress that is linked to the reduction in ABCA-1 levels and macrophage cholesterol accumulation. We analyzed if the effect of AGE-albumin in disturbing macrophage reverse cholesterol transport (RCT) can be prevented by silencing or knoc…
The inverse association between HDL and coronary heart disease is well established by epidemiological studies although recent clinical trials and genetic studies have failed in demonstrating cardiovascular benefits by increasing plasma HDL-cholesterol levels. This may be related to the great heterogeneity of HDL particle in size and composition and to the partial loss of function of this…
In diabetes mellitus (DM), alterations in lipid and lipoprotein metabolism contribute to the elevated risk of atherosclerotic disease. Hyperglycemia is an important contributor for micro and macrovascular disease in DM, leading to the generation of reactive oxygen species (ROS) and the formation of reactive oxoaldehydes, such as glyoxal, methylglyoxal and glycolaldehyde that mediate the f…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 13 / 7 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 27 / 11 | Completed scholarships in Brazil |
| 5 / 4 | Completed scholarships abroad |
| 50 / 27 | All research grants and scholarships |
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