CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina (FM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
PhD at Physiology from Universidade de São Paulo (1998). Postdoctoral feloowship at Metabolism,Endocrinology and Nutrition, University of Washington, Seattle, USA. Co-responsible for the Lipids Laboratory (LIM 10), University of Sao Paulo Medical School. Professor of Universidade Nove de Julho (UNINOVE). Experience in Lipid Metabolism - Lipoprotein Metabolism in Diabetes and Exercise (Source: Lattes Curriculum)
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The etiopathogenesis of Breast Cancer is diverse and the molecular classification of tumors and the calculation of recurrence score are used as basis for prognosis and therapeutic choice. High density lipoproteins (HDL) are inversely associated with tumor genesis by modulating the lipid content required for tumor replication, adhesion and migration, and performing antioxidant and anti-inf…
Diabetes Mellitus (DM) and its chronic complications are the greatest public health problem. It is a must to develop approaches that help to control glycemia and to reduce the incidence of complications. Target territories to develop complications, which will be focused on in this proposal, include kidney, cardiovascular system, brain (Alzheimer's Disease also referred to as DM3) and live…
(Only some records are available in English at this moment)
The accumulation of cholesterol in macrophages in the arterial wall is accompanied by the infiltration of immune cells and the secretion of inflammatory cytokines. In these cells, the high expression of the receptor for advanced glycation products (AGER) and toll-like receptor 4 (TLR-4) triggers inflammatory pathways, after signaling by lipopolysaccharides (LPS) and/or advanced glycation …
Cardiovascular disease (CVD) is the leading cause of mortality in individuals with chronic kidney disease (CKD). The gradual loss of renal function is influenced and also affects traditional risk factors for CVD; however, the control of blood pressure and dyslipidemia is not able to prevent cardiovascular morbidity and mortality. This is attributed to the action of non-classical risk fact…
Advanced glycation products (AGE) are important contributors to metabolic memory by mediating cellular modifications during the decompensation metabolic period, which are sustained after adequate metabolic control in diabetes mellitus (DM). We have recently demonstrated a persistent effect of albumin modified by advanced glycation (albumin-AGE) on impaired cholesterol removal from macroph…
(Only some records are available in English at this moment)
Advanced glycation end products (AGE) are elevated in diabetes mellitus (DM) and predict the development of atherosclerosis. AGE-albumin induces oxidative stress that is linked to the reduction in ABCA-1 levels and macrophage cholesterol accumulation. We analyzed if the effect of AGE-albumin in disturbing macrophage reverse cholesterol transport (RCT) can be prevented by silencing or knoc…
The inverse association between HDL and coronary heart disease is well established by epidemiological studies although recent clinical trials and genetic studies have failed in demonstrating cardiovascular benefits by increasing plasma HDL-cholesterol levels. This may be related to the great heterogeneity of HDL particle in size and composition and to the partial loss of function of this…
In diabetes mellitus (DM), alterations in lipid and lipoprotein metabolism contribute to the elevated risk of atherosclerotic disease. Hyperglycemia is an important contributor for micro and macrovascular disease in DM, leading to the generation of reactive oxygen species (ROS) and the formation of reactive oxoaldehydes, such as glyoxal, methylglyoxal and glycolaldehyde that mediate the f…
(Only some records are available in English at this moment)
| 16 / 10 | Completed research grants |
| 31 / 15 | Completed scholarships in Brazil |
| 5 / 4 | Completed scholarships abroad |
| 52 / 29 | All research grants and scholarships |
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