Abstract
Glioblastoma (GBM) is the most malignant and prevalent of all brain tumors, leading to the death of most patients within a year and a half after the initial diagnosis. Hypoxia is a frequent feature of GBM that leads to the overexpression of several proteins, including carbonic anhydrase IX (CAIX). CAIX is a transmembrane metalloenzyme responsible for the reversible hydration of carbon dio…