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Mauricio Ferreira Marcondes Machado

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Universidade de Mogi das Cruzes (UMC). Campus da Sede Mogi das Cruzes. Pró-Reitoria Acadêmica  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Holds a bachelor's degree in Biomedicine from the University of Mogi das Cruzes (2000), a Master's degree in Biotechnology from the University of Mogi das Cruzes (2004) and a PhD in Biological Sciences (Molecular Biology) from the Federal University of São Paulo (2008). He is currently professor at level 1 of the University of Mogi das Cruzes and researcher at the University of Mogi das Cruzes. Our team studied the in vivo and in vitro effect of Metacaspases, which are proteolytic enzymes involved in programmed cell death (apoptosis) in unicellular organisms such as yeasts, protozoa and fungi. We performed cloning and site mutations aimed at chemical, physicochemical and structural characterization of these enzymes. We also evaluated the in vivo effect of Saccharomyces cerevisiae metacaspase, through immunofluorescence techniques, flow cytometry, among others using a model knocked out of this yeast for the metacaspase gene. (Source: Lattes Curriculum)

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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

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DALIO, FERNANDA M.; MACHADO, MAURICIO F. M.; MARCONDES, MARCELO F.; JULIANO, MARIA A.; CHAGAS, JAIR R.; CUNHA, RODRIGO L. O. R.; OLIVEIRA, VITOR. CPP-Ala-Ala-Tyr-PABA inhibitor analogs with improved selectivity for neurolysin or thimet oligopeptidase. Biochemical and Biophysical Research Communications, v. 522, n. 2, p. 368-373, . Web of Science Citations: 0. (19/05936-0, 18/09158-0)

MACHADO, MAURÍCIO F. M.; RIOLI, VANESSA; DALIO, FERNANDA M.; CASTRO, LEANDRO M.; JULIANO, MARIA A.; TERSARIOL, IVARNE L.; FERRO, EMER S.; JULIANO, LUIZ; OLIVEIRA, VITOR. The role of Tyr(605) and Ala(607) of thimet oligopeptidase and Tyr(606) and Gly(608) of neurolysin in substrate hydrolysis and inhibitor binding. Biochemical Journal, v. 404, n. 2, p. 279-288, .

GADELHA, ARY; MACHADO, MAURICIO F. M.; YONAMINE, CAMILA M.; SATO, JOAO R.; JULIANO, MARIA A.; OLIVEIRA, VITOR; BRESSAN, RODRIGO A.; HAYASHI, MIRIAN A. F.. Plasma Ndel1 enzyme activity is reduced in patients with schizophrenia - A potential biomarker?. JOURNAL OF PSYCHIATRIC RESEARCH, v. 47, n. 5, p. 657-663, . Web of Science Citations: 16. (09/17726-9, 11/50740-5, 10/01394-4)

JUDICE, WAGNER A. S.; FERRAZ, LETICIA SILVA; LOPES, RAYSSA DE MELLO; VIANNA, LUAN DOS SANTOS; SIQUEIRA, FABIO DA SILVA; DI IORIO, JULIANA F.; DALZOTO, LAURA DE AZEVEDO MAFFEIS; TRUJILHO, MARIANA NASCIMENTO ROMERO; SANTOS, TAIZ DOS REIS; MACHADO, MAURICIO F. M.; et al. Cysteine proteases as potential targets for anti-trypanosomatid drug discovery. Bioorganic & Medicinal Chemistry, v. 46, . Web of Science Citations: 0. (18/25747-5, 19/05936-0, 16/25112-4)

GILIO, JOYCE M.; MARCONDES, MARCELO F.; FERRARI, DEBORA; JULIANO, MARIA A.; JULIANO, LUIZ; OLIVEIRA, VITOR; MACHADO, MAURICIO F. M.. Processing of metacaspase 2 from Trypanosoma brucei (TbMCA2) broadens its substrate specificity. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, v. 1865, n. 4, p. 388-394, . Web of Science Citations: 6. (12/50191-4, 15/11190-0, 14/20847-0)

ANTUNES, ALYNE ALEXANDRINO; PASSOS JESUS, LARISSA DE OLIVEIRA; MANFREDI, MARCELLA ARAUJO; DE SOUZA, ALINE APARECIDA; MARCONDES MACHADO, MAURICIO FERREIRA; MORAES E SILVA, PAMELA; ICIMOTO, MARCELO YUDI; JULIANO, MARIA APARECIDA; JULIANO, LUIZ; DE SOUZA JUDICE, WAGNER ALVES. Thermodynamic analysis of Kex2 activity: The acylation and deacylation steps are potassium- and substrate-dependent. Biophysical Chemistry, v. 235, p. 29-39, . Web of Science Citations: 1. (16/25112-4, 15/11190-0, 14/02205-1)

MACHADO, MAURICIO F. M.; MARCONDES, MARCELO F.; RIOLI, VANESSA; FERRO, EMER S.; JULIANO, MARIA A.; JULIANO, LUIZ; OLIVEIRA, VITOR. Catalytic properties of thimet oligopeptidase H600A mutant. Biochemical and Biophysical Research Communications, v. 394, n. 2, p. 429-433, . Web of Science Citations: 1.

MACHADO, MAURICIO F. M.; MARCONDES, MARCELO F.; JULIANO, MARIA A.; MCLUSKEY, KAREN; MOTTRAM, JEREMY C.; MOSS, CATHERINE X.; JULIANO, LUIZ; OLIVEIRA, VITOR. Substrate specificity and the effect of calcium on Trypanosomabrucei metacaspase 2. FEBS Journal, v. 280, n. 11, p. 2608-2621, . Web of Science Citations: 10.

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