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Daniela Barretto Barbosa Trivella

CV Lattes GoogleMyCitations ORCID

Ministério da Ciência, Tecnologia e Inovações (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Principal Investigator and head of research at LNBio-CNPEM (Campinas, SP). Graduated in Biological Sciences (2003) from the Federal University of Santa Catarina , Master in Biotechnology (2006) from the Federal University of Santa Catarina, PhD in Sciences from the University of Sao Paulo (2010) and pos-doctoral research at the Institute of Chemistry, UNICAMP (2010-2013), at the University of California at San Diego (2012) and at the University of Nottingham (2016). Is an independent researcher at the Brazilian National Laboratory for Biosciences. Has experience in the area of Medicinal Chemistry, Biochemistry and Biophysics, with emphasis on structural biology (protein crystallography), thermodynamics (microcalorimetry) and enzyme kinetics. The main research interest is on the discovery of new bioactive natural products, mainly those of marine and microbial origin. Develops tools for the structural and biochemical characterisation of proteins with pharmaceutical interest and their interaction with natural products. (Source: Lattes Curriculum)

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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Data from Web of Science

TRIVELLA, DANIELA B. B.; PEREIRA, ALBAN R.; STEIN, MARTIN L.; KASAI, YUSUKE; BYRUM, TARA; VALERIOTE, FREDERICK A.; TANTILLO, DEAN J.; GROLL, MICHAEL; GERWICK, WILLIAM H.; MOORE, BRADLEY S.. Enzyme Inhibition by Hydroamination: Design and Mechanism of a Hybrid Carmaphycin-Syringolin Enone Proteasome Inhibitor. CHEMISTRY & BIOLOGY, v. 21, n. 6, p. 782-791, . Web of Science Citations: 12. (11/21358-5)

TRIVELLA, DANIELA B. B.; DOS REIS, CAIO V.; LIMA, LUIS MAURICIO T. R.; FOGUEL, DEBORA; POLIKARPOV, IGOR. Flavonoid interactions with human transthyretin: Combined structural and thermodynamic analysis. Journal of Structural Biology, v. 180, n. 1, p. 143-153, . Web of Science Citations: 24. (06/01708-3, 09/54035-4)

WAECHTER, FERNANDA; DA SILVA, GLORIA N. S.; WILLIG, JULIA B.; DE OLIVEIRA, CRISTIANE B.; VIEIRA, BRUNA D.; TRIVELLA, DANIELA B. B.; ZIMMER, ALINE R.; BUFFON, ANDREIA; PILGER, DIOGO A.; GNOATTO, SIMONE C. B.. Design, Synthesis and Biological Evaluation of Betulinic Acid Derivatives as New Antitumor Agents for Leukemia. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, v. 17, n. 13, p. 1777-1785, . Web of Science Citations: 3. (14/10753-9)

DE FELICIO, RAFAEL; BALLONE, PATRICIA; BAZZANO, CRISTINA FREITAS; ALVES, LUIZ F. G.; SIGRIST, RENATA; INFANTE, GINA POLO; NIERO, HENRIQUE; RODRIGUES-COSTA, FERNANDA; FERNANDES, ARTHUR ZANETTI NUNES; TONON, LUCIANE A. C.; et al. Chemical Elicitors Induce Rare Bioactive Secondary Metabolites in Deep-Sea Bacteria under Laboratory Conditions. METABOLITES, v. 11, n. 2, . Web of Science Citations: 0. (14/10753-9, 17/12436-9, 15/19906-5)

FONSECA, EMANUELLA M. B.; TRIVELLA, DANIELA B. B.; SCORSATO, VALERIA; DIAS, MARIANA P.; BAZZO, NATALIA L.; MANDAPATI, KISHORE R.; DE OLIVEIRA, FABIO L.; FERREIRA-HALDER, CARMEN V.; PILLI, RONALDO A.; MIRANDA, PAULO C. M. L.; et al. Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates. Bioorganic & Medicinal Chemistry, v. 23, n. 15, p. 4462-4471, . Web of Science Citations: 4. (09/51602-5, 11/03054-9, 11/15792-4, 10/17544-5)

GRIGOLETTO, DIANA F.; TRIVELLA, DANIELA B. B.; TEMPONE, ANDRE G.; RODRIGUES, ANDRE; CORREIA, ANA MARIA L.; LIRA, SIMONE P.. Antifungal compounds with anticancer potential from Trichoderma sp. P8BDA1F1, an endophytic fungus from Begonia venosa. Brazilian Journal of Microbiology, v. 51, n. 3, . Web of Science Citations: 0. (14/10753-9, 14/15760-3, 13/50228-8, 14/12021-5)

CARNEIRO, VANIA M. T.; TRIVELLA, DANIELA B. B.; SCORSATO, VALERIA; BERALDO, VIVIANE L.; DIAS, MARIANA P.; SOBREIRA, TIAGO J. P.; APARICIO, RICARDO; PILLI, RONALDO A.. Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 97, p. 42-54, . Web of Science Citations: 4. (13/07607-8, 09/51602-5, 11/00457-5, 10/17544-5)

TONETO NOVAES, LUIZ FERNANDO; AVILA, CAROLINA MARTINS; PELIZZARO-ROCHA, KARIN JULIANE; VENDRAMINI-COSTA, DEBORA BARBOSA; DIAS, MARINA PEREIRA; BARBOSA TRIVELLA, DANIELA BARRETO; DE CARVALHO, JOAO ERNESTO; FERREIRA-HALDER, CARMEN VERISSIMA; PILLI, RONALDO ALOISE. (-)-Tarchonanthuslactone: Design of New Analogues, Evaluation of their Antiproliferative Activity on Cancer Cell Lines, and Preliminary Mechanistic Studies. CHEMMEDCHEM, v. 10, n. 10, p. 1687-1699, . Web of Science Citations: 5. (13/08896-3, 12/24385-6, 10/08673-6, 09/51602-5, 12/09254-2, 10/17544-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

TRIVELLA, Daniela Barretto Barbosa. Estudos bioquímicos e estruturais com o complexo proteassomo : busca de novos inibidores e mecanismos de resistência e inibição deste alvo contra o câncer. Dissertação (Mestrado) -  Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia, Inovações e Comunicações (Brasil).  (14/10753-9

TRIVELLA, Daniela Barretto Barbosa. Bases moleculares e estruturais do reconhecimento de ligantes pela proteína transtirretina humana. Tese (Doutorado) -  Instituto de Física de São Carlos.  Universidade de São Paulo (USP).  São Carlos.  (06/01708-3

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