Humberto Doriguetto Gravina

Biochemist and immunologist experienced in cellular and molecular biology, mainly applied in infectious diseases. My experience includes in vitro and in vivo technics in a variety of research lines on immunometabolism, pathogenesis, and immunotherapy in human and animal diseases. Currently at FCFRP/USP-RP, I study through proteomics and transcriptomics the cargo of extracellular vesicles from the plasma of people living with HIV (PLWH). Mostly, I have studied the inflammatory regulation, cell differentiation, and the differential and cooperative use of signaling pathways triggered by innate immunity receptors/sensors (TLRs, NLRs, and STING/cGAS). I also bioprospected natural products with antiviral and anticarcinogenic potential; produced inputs for the development of diagnostic kits (including monoclonal antibody selection); and characterizated biologically new viruses. My experiences comprise virology (DNA: herpesviruses and RNA: arboviruses, SARS-CoV-2), parasitology (Chagas disease and malaria), bacteriology (Mycobacterium spp. and Brucella abortus), and induction of metabolic diseases, like cancer and osteoporosis. I worked as a Fundação Araucária's postdoc fellow at Instituto Carlos Chagas/ Fiocruz-PR (2016-2019) and a CNPq/FINEP's (SET-A) PD fellow in the task force against COVID-19 from the MCTIC Virus Network and helded at CNPEM (2020- 2021). (Source: Lattes Curriculum)